Clinical trials: Effect of Drugs
Healthy
AV650 Drug-Drug Interaction Study
The purpose of this study is to evaluate the effects that paroxetine and fluvoxamine have on the way the body distributes, breakdowns and eliminates AV650.
- Trial name
- NCT00456560
- Testing
- AV650, Fluvoxamine, Paroxetine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Avigen
Seizure Recurrence
Mobile Video Education and Machine Learning-Based Risk Prediction in Neonatal Seizure Management
This mixed-methods study will develop a machine learning-based model to identify infants at high risk of seizure recurrence after discharge from the neonatal intensive care unit.
- Trial name
- NCT07695623
- Testing
- Mobile Video-Supported Education
- Volunteers
- 60 people
- Sponsor
- Istanbul Saglik Bilimleri University
Autism Spectrum Disorder, Autistic Disorder
Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
The aim of this randomized controlled trial is to determine if a nutritional supplement containing broccoli sprout and seed extracts, a rich source of sulforaphane, is effective in reducing core symptoms of autism spectrum…
- Conditions
- Autism Spectrum Disorder, Autistic Disorder, Neurodevelopmental Disorder, Childhood Developmental Disorders, Pervasive
- Trial name
- NCT02909959
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Toxic Epidermal Necrolysis, Immunotherapy
New Therapeutic Target for Toxic Epidermal Necrolysis (TEN) Using Anti-CD38+ Monoclonal Antibodies.
Toxic Epidermal Necrolysis (TEN) are rare diseases that are dermatologic emergencies characterized by widespread epidermal necrosis and sloughing of skin. A hundred patients are affected each year in France.
- Conditions
- Toxic Epidermal Necrolysis, Immunotherapy, Cutaneous Adverse Drug Reactions (CADR)
- Trial name
- NET-CD38 (NCT07110662)
- Testing
- DARATUMUMAB (DARZALEX®)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Chronic Pain
Effect Study of on Intervention on Pain, Function, Health and Behaviour for Older Adults Living With Chronic Pain
The aim for the study is to examined the effect of an individually tailored integrated behavioral medicine in physiotherapy intervention including functional exercise, for older adults, having chronic musculoskeletal pain, living…
- Trial name
- NCT02953470
- Testing
- Individual tailored functional exercise, Standard care
- Where
- Norway
- Volunteers
- 105 people
- Sponsor
- Oslo Metropolitan University
Cervical Pain
Effect of Group Pilates and Yoga Exercise Classes for Chronic Cervical Pain
Exercise has been found to be effective in alleviating back and neck pain. Two exercise methods which are available in the community in a group format are Yoga and Pilates.
- Trial name
- Pilates/Yoga (NCT01999283)
- Testing
- Yoga Group Exercise, Pilates Group Mat Exercise
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- Wayne State University
Epilepsy
Standardized Educational Plan for Epilepsy Patients With Comorbidities
Epilepsy requires long-term drug treatment and is frequently associated with other clinical conditions. Combinations of antiepileptic drugs and other compounds are fairly common and increase with age.
- Trial name
- EDU-COM (NCT01804322)
- Testing
- Standardized educational plan, usual care
- Where
- Italy
- Volunteers
- 187 people
- Sponsor
- San Gerardo Hospital
Postoperative Pain, Apical Periodontitis
Effect of Low-level Laser Therapy Versus Calcium Hydroxide Intracanal Medication on Postoperative Pain and Substance P Levels in Patients With Symptomatic Apical Periodontitis
a randomized clinical study to compare the effect of using low level laser therapy versus calcium hydroxide intra-canal medication on: Incidence and intensity of postoperative pain in patients with symptomatic apical…
- Trial name
- NCT04594317
- Testing
- low level laser therapy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy Volunteers
A Study of the Interaction of Other Drugs With TAK-279 in Healthy Adults
The main aim of this study is to find out how several doses of TAK-279 affects the body of healthy adults and processes midazolam and repaglinide (pharmacokinetics or PK).
- Trial name
- NCT06290050
- Testing
- Midazolam, Repaglinide, TAK-279
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Takeda
Glaucoma, Primary Open Angle, Ocular Hypertension
Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to compare the efficacy and tolerance of generic travoprost with its brand name formulation. In this open label, randomized, crossover study, the primary outcome will be intraocular pressure and the…
- Trial name
- NCT02796560
- Testing
- Brand name travoprost, Generic travoprost
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Université de Sherbrooke
Drug-Induced Acute Liver Injury
Bicyclol in the Treatment of Antineoplastic Drug-induced Liver Injury.
The clinical trial is designed to evaluate the efficacy of bicyclol for patients with antineoplastic drug-induced liver injury and investigate factors effecting the therapeutic outcome.
- Trial name
- NCT05711459
- Testing
- Bicyclol tablets
- Where
- China
- Volunteers
- 5,405 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Healthy
Drug-Drug Interaction of Cardizem LA (Diltiazem Hydrochloride) on Pitavastatin
This is a Phase 4, single-center, open-label, fixed-sequence, multiple-dose, 2-way drug-drug interaction study.
- Trial name
- NCT01422382
- Testing
- Pitavastatin (NK-104), Diltiazem (Cardizem LA) 240 mg QD
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Diastolic Dysfunction, Hypertension
To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure.
Patients who have had high blood pressure for a long time may have diastolic dysfunction. Diastolic Dysfunction is when your heart has difficulty filling and emptying, and relaxing adequately.
- Trial name
- NCT00170924
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Novartis
Healthy Participants
A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants
This is a study in healthy participants designed to assess the effect of multiple doses of itraconazole, gemfibrozil, or carbamazepine on the drug levels of a single-dose of BMS-986278.
- Trial name
- NCT05932303
- Testing
- BMS-986278, Itraconazole, Gemfibrozil
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Irritable Bowel Syndrome
Effect of Asimadoline, a Member of a New Medication Class, on Acute Attacks of Pain in Irritable Bowel Syndrome
The treatment of acute pain in patients with irritable bowel symptoms is suboptimal. This is a placebo controlled study of the on demand treatment of pain experienced over a 4 week period in patients with irritable bowel…
- Trial name
- NCT00955994
- Testing
- asimadoline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Impaired Glucose Tolerance, Insulin Sensitivity
Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study will test the effect of four common oral anti-diabetic agents on hepatic insulin sensitivity in South Asian women with impaired glucose tolerance or impaired fasting glucose.
- Conditions
- Impaired Glucose Tolerance, Insulin Sensitivity, Glucose Metabolism Disorders
- Trial name
- DIASA3 (NCT04662866)
- Testing
- Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
Drug Induced Liver Injury, Drug-Induced Kidney Injury
A Multicenter Observational Study on Safety of the Herbal Medicines at Inpatient Setting
Prospective observations on safety of the herbal medicines regarding liver and kidney injuries at inpatient setting of four sites in South Korea which are located at each quadrant of the country.
- Conditions
- Drug Induced Liver Injury, Drug-Induced Kidney Injury, Herbal Medicine Adverse Reaction
- Trial name
- NCT04269486
- Where
- South Korea
- Volunteers
- 287 people
- Sponsor
- Korea Institute of Oriental Medicine
Healthy
Influence of Tocolytical Medications on Hemodynamics (Central and Peripheral) and Vascular Function in a Pilot Study to Determine the Design of the Final Study and the Final Study Itself
This trial will consist of two parts: A pilot study in a three-way cross over trial to determine the highest well tolerated dose of Ritodrine (Pre-Par®), the impact of Atosiban (Tractocile®) on the hemodynamics and hence the…
- Trial name
- NCT00679705
- Testing
- Ritodrine, Atosiban
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Drug Induced Liver Injury
Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury
The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.
- Trial name
- NCT01000766
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Volunteers
A Study to Determine the Bioavailability and Food Effect of a Single TAK-935 Dose in Healthy Participants
The purpose of this study is to assess the relative bioavailability (BA) of 300 milligram (mg) TAK-935 tablets compared to 300 mg of TAK-935 solution and to determine the effect of food on the BA of TAK-935 300 mg tablets in…
- Trial name
- NCT02906813
- Testing
- TAK-935 Tablets, TAK-935 Oral Solution
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Takeda
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