Clinical trials: Effect of Drugs
Stevens - Johnson Syndrome
G-CSF in the Treatment of Toxic Epidermal Necrolysis
NeupoNET aims to evaluate interest of G-CSF in the treatment of Toxic Epidermal necrolysis. This is a prospective randomized controlled trial.
- Trial name
- NeupoNET (NCT02739295)
- Testing
- recombinant granulocyte - colony stimulating factor, NaCl 0.9%
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- University of Liege
to Assess Effect of Peer-led Education
Effect of Peer-led Educational Intervention on Treatment Outcomes Among Adults With Drug-susceptible Pulmonary Tuberculosis in South Omo and Ari Zone, Southern Ethiopia
The study might come up with valuable findings to address poor treatment outcome, poor quality of life, disability score and depressive symptoms. The findings may also be decreased health professional workload.
- Trial name
- DS-PTB (NCT07387601)
- Testing
- peer-led education
- Where
- Ethiopia
- Volunteers
- 250 people
- Sponsor
- Bahirdar University
Cardiotoxicity
Effect of Trimetazidine on Radiotherapy-induced Heart Damage.
This is a randomized controlled trial. 80 patients with thoracic radiotherapy will be included. Participants will be randomly divided into experimental group or control group.
- Trial name
- NCT04939857
- Testing
- Trimetazidine
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Blood Pressure
An Explorative Study on the Pharmacokinetics and Pharmacodynamics of Sunitinib in Healthy Volunteers
The study is conducted: to investigate the influence of sunitinib (study drug) on the plasma biomarkers VEGF-A, VEGF-C, soluble VEGFR-2, and soluble VEGFR-3 (vessel endothelial growth factors) and on the blood pressure; to…
- Trial name
- NCT00904657
- Testing
- sunitinib (Sutent)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Type 2 Diabetes Mellitus
Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes Taking Twice-Daily Exenatide or Once-Weekly Exenatide
The purpose of this substudy is to obtain CGM data from individuals taking exenatide. The CGM measurements gathered before starting and during treatment with exenatide IR and/or exenatide LAR will help determine the…
- Trial name
- NCT00803920
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- HealthPartners Institute
HIV Infections
Study of Pharmacokinetics in HIV-infected Women
Women represent an increasing proportion of HIV cases globally and in Canada, yet are underrepresented in clinic trials. It is therefore critical to conduct this study on antiretroviral (ARV) pharmacokinetics (PK) in women to…
- Trial name
- NCT00433979
- Testing
- antiretroviral treatment
- Where
- 15 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Women's College Hospital
HIV Infections
Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks
To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated quickly from the body, it must be taken frequently.
- Trial name
- NCT00000670
- Testing
- Probenecid, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Cancer, Nonsmall Cell, Perioperative
Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy
Cough after lobectomy is common. The prevention and treatment of cough after lobectomy is not standardized. Breztri Aerosphere is often used to relieve cough.
- Conditions
- Lung Cancer, Nonsmall Cell, Perioperative, Cough, Drug Effect
- Trial name
- NCT05472350
- Testing
- Breztri Aerosphere
- Volunteers
- 128 people
- Sponsor
- Jianxing He
Evidence of Liver Transplantation
Uses of Immunosuppression Therapy in Patients With Liver Transplantation
Conventionally, the outcome of liver transplantation is usually reported in terms of graft and patient survival, medical and surgical complications, but lack of health-related quality of life (HRQOL) that might be associated with…
- Trial name
- NCT01834690
- Where
- Taiwan
- Volunteers
- 314 people
- Sponsor
- Chang Gung Memorial Hospital
Cholestasis
Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects
In participants with inadequate response/intolerance to ursodeoxycholic acid (UDCA) taking obeticholic acid (OCA) who experience pruritus (due to primary biliary cholangitis [PBC], OCA, or both) the addition of linerixibat to OCA…
- Trial name
- NCT04053023
- Testing
- GSK2330672 (linerixibat), Obeticholic acid
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis, Tuberculosis
Investigation of the Effect of N Acetylcysteine Against Anti-Tuberculosis Drugs Induced Liver Toxicity
Tuberculosis is one of the major health problems in developing countries. Isoniazid, rifampin and pyrazinamide, the first line drugs used for tuberculosis chemotherapy, are associated with hepatotoxicity.
- Trial name
- NCT00564642
- Testing
- N Acetylcysteine
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- National Research Institute of Tuberculosis and Lung Disease, Iran
Alzheimer's Disease
Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
Rilapladib is a potent and selective inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), which was previously under development for the treatment of atherosclerosis and is currently being developed for the treatment…
- Trial name
- NCT02130661
- Testing
- Rilapladib 25 mg, Rilapladib 250 mg, Itraconazole
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ankylosing Spondylitis, Therapeutic Agent Toxicity
A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS
The selective cox-2 inhibitor has been widely used in the treatment of Ankylosing spondylitis (AS). The Imrecoxib is a new cox-2 inhibitor. But the treatment strategy has not been decided yet.
- Trial name
- NCT04400786
- Testing
- intermittent treatment, continuous treatment
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson Disease (PD)
Pilot Deprescribing of Antimuscarinic Overactive Bladder Medications in Parkinson Disease
This is an unblinded, non-randomized National Institute of Health (NIH) Stage I of Behavioral Intervention Development trial. The investigators will enroll 20 subjects with Parkinson disease (PD) for a series of 20 of N-of-1…
- Trial name
- NCT07627529
- Testing
- Overactive bladder antimuscarinic deprescribing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Psychological Distress
Lifestyle Hub Pilot Study
This study will examine the effects of a smartphone-based lifestyle medicine (LM) for improving psychological well-being in Chinese population.
- Trial name
- NCT04295369
- Testing
- Lifestyle Medicine
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cocaine Dependence
Effects of Propranolol on Responses to Drug-Related Imagery Scripts
Background: Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of…
- Trial name
- NCT00688805
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Human Papillomavirus (HPV) Infection, HPV Vaccination Acceptance/Intention
Effect of Different HPV Education Methods on Vaccination Intention in Young Women
Detailed Description Human papillomavirus (HPV) is one of the leading causes of cervical cancer and can be prevented by vaccination.
- Trial name
- NCT07420556
- Testing
- Video-Based HPV Education, Face-to-Face HPV Education
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Emel GÜÇLÜ CİHAN
Schizophrenia, Drug Induced Movement Disorder, Unspecified
Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics
D2 dopaminergic receptor blockers, used to treat schizophrenia, can lead to the onset of movement disorders. Drug-induced movement disorders encompass several syndromes.
- Conditions
- Schizophrenia, Drug Induced Movement Disorder, Unspecified, Oxidative Stress
- Trial name
- NCT03790345
- Testing
- Pyridoxine, Cobalamin
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methadone
Drug Interaction Study of Isavuconazole and Methadone
The primary purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics (PK) of methadone after single dose administration.
- Conditions
- Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methadone, Healthy Volunteers
- Trial name
- NCT01582425
- Testing
- Isavuconazole, Methadone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Diabetes Mellitus
Efficacy of Pioglitazone on Microcirculation in Type 2 Diabetes Patients Treated With Insulin
The purpose of this study is to measure microcirculation in type 2 diabetes patients with peripheral edema who are taking pioglitazone, once daily (QD).
- Trial name
- NCT00676260
- Testing
- Pioglitazone
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Takeda
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