Clinical trials: Effect of Drugs
Healthy
Effects of Dietary Conditions on Drug Response
This non-treatment study will examine how different dietary conditions may affect a person's response to commonly used drugs.
- Trial name
- NCT04315961
- Testing
- Blinded drug dose conditions
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Myeloproliferative Neoplasm, Primary Myelofibrosis
Sympathicomimetic Agonist in Patients With Myeloproliferative Neoplasms With JAK2-mutation
The aim of this phase II study is to test a novel concept in the treatment of patients with myeloproliferative neoplasms (MPN), a disease of the bone marrow.
- Conditions
- Myeloproliferative Neoplasm, Primary Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera
- Trial name
- NCT02311569
- Testing
- Mirabegron
- Where
- 11 sites in Switzerland
- Volunteers
- 39 people
- Sponsor
- Swiss Cancer Institute
Pulmonary Arterial Hypertension
Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension
In the present study, the investigators want to investigate the prevalence of BMPR-2 gene mutations in the Korean PAH patients (Step-I) and to test that the PAH patients treated with iloprost inhalation solution (Ventavis®) would…
- Trial name
- PILGRIM (NCT01054105)
- Testing
- Iloprost
- Where
- 6 sites in South Korea
- Volunteers
- 73 people
- Sponsor
- Gachon University Gil Medical Center
Acute Coronary Syndrome
Effect of Free Ticagrelor Fraction on Platelet Membrane Post MI
The purpose of this study is to assess: the population pharmacokinetics of unbound ticagrelor and its metabolite in acute coronary syndrome patients treated by ticagrelor ticagrelor and its metabolite levels by LC-MS/MS
- Trial name
- PLATIME (NCT03658005)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
RSV Infection
Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy Subjects
A Non-Randomized, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects
- Trial name
- NCT04871724
- Testing
- EDP-938, Fluconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Obesity, Overweight
A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects
The purpose of this study is to determine whether 2 doses of the combination of naltrexone SR and bupropion SR are safe and effective in the treatment of obesity.
- Trial name
- NCT00532779
- Testing
- Naltrexone SR 16 mg/Bupropion SR 360 mg /day, Naltrexone SR 32 mg/Bupropion SR 360 mg /day, Ancillary therapy
- Where
- 34 sites in United States
- Volunteers
- 1,742 people
- Sponsor
- Orexigen Therapeutics, Inc
Major Depressive Disorder
Relative Bioavailability (RBA) Study of LY03005 vs Pristiq®
The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in…
- Trial name
- NCT03357796
- Testing
- LY03005, Pristiq
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Stevens-Johnson Syndrome
Corneal Epitheliotropic Factors in Autologous Serum Eye Drops in Nonautoimmune and Stevens-Johnson Syndrome With Dry Eye
Autologous serum eye drops (ASE) have been becoming popular in treatment of severe dry eye for the past decade. One of the most beneficial properties of the ASE over artificial eye drops is the epitheliotropic capacity owing to…
- Trial name
- NCT01122303
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Drug-Interactions
Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation
The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting.
- Trial name
- EFA-1 (NCT00465322)
- Testing
- fluvastatin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Being Registered With Kelkit District State Hospital Home Health Unit, Being a Home Care Patient
Determining the Effect of Home Care Training on Anxiety and Depression Levels of Caregivers
This study was conducted to determine the effects of home care training given to caregivers of patients receiving home care services on the anxiety and depression levels of the caregivers.
- Trial name
- NCT07053553
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Gümüşhane Universıty
Small Intestinal NET, Carcinoid Heart Disease
Lanreotide Combined With Telotristat Ethyl or Placebo for the First-line Treatment in Patients With Advanced Well Differentiated Small Intestinal Neuroendocrine Tumours (siNET) With Highly-functioning Carcinoid Syndrome
This is a randomized phase III clinical trial of Lanreotide combined with Telotristat ethyl or placebo for the first-line treatment in patients with advanced well differentiated small intestinal neuroendocrine tumours (siNET)…
- Trial name
- TELEFIRST (NCT04065165)
- Testing
- Telotristat Ethyl, Lanreotide
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Schizophrenia
Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
This study will determine the effectiveness of oral risperidone versus long-acting injectable risperidone in treating people with first-episode schizophrenia.
- Trial name
- NCT00330551
- Testing
- Oral Risperidone, Risperidone in Long-Acting Injectable Form (Consta)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
NATIENS: Optimal Management and Mechanisms of SJS/TEN
The North American Therapeutics in Epidermal Necrolysis Syndrome (NATIENS) study is a multicenter double-blind randomized controlled assessment of two arms - one of systemic immunomodulatory therapy (etanercept) and one of…
- Trial name
- NATIENS (NCT02987257)
- Testing
- Harmonized supportive care, Etanercept 50 mg sc day 1 and day 4
- Where
- 14 sites in United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Drug Usage
Gabapentin as Adjunctive Treatment for Postoperative Pain Control
The specific aims of this research study are to use 600 mg gabapentin as an adjunctive treatment for acute postoperative pain control in order to reduce postoperative opiate consumption and improve postoperative pain control.
- Trial name
- NCT02490345
- Testing
- gabapentin
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Adverse Drug Event
Evaluation of the Implementation of the Pharmacogenetics and Personalized Medicine Program "MedeA" in the Extremadura Health Service.
An open longitudinal observational study, non-randomized, which will include the adult population, attended by the SES, in which preference will be given to those patients under treatment with drugs that can produce relevant…
- Trial name
- MedeA (NCT06607445)
- Where
- Spain
- Volunteers
- 6,445 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Universitario de Badajoz
Inflammatory Disease, Drug Side Effect
Active Pharmacovigilance Study of the Medicine Rinvoq™ (Upadacitinib)
The LOOK-UP is an investigator-initiated clinical study with the aim of monitoring the post-marketing safety of the medicine Rinvoq™ (upadacitinib), which is indicated for the treatment of rheumatoid arthritis, psoriatic…
- Conditions
- Inflammatory Disease, Drug Side Effect, Drug Use, Adverse Drug Event
- Trial name
- LOOK-UP (NCT06498167)
- Testing
- Upadacitinib
- Where
- 3 sites in Portugal
- Volunteers
- 150 people
- Sponsor
- Universidade do Porto
Malaria
Food-Effect Bioavailability Study of AQ-13, a Candidate Antimalarial
The purpose of this study is to test the safety of a 2100 mg dose of AQ-13, a new candidate antimalarial active against drug-resistant P.
- Trial name
- NCT00455494
- Testing
- AQ-13
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Drug-induced Liver Injury, Autoimmune Hepatitis
Discrimination of DILI and AIH by Artificial Intelligence
A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis.
- Trial name
- NCT05532345
- Where
- China
- Volunteers
- 2,583 people
- Sponsor
- Beijing Friendship Hospital
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