Clinical trials: Effect of Sleep Deprivation
Sleep Deprivation, Sleep Wake Disorders
Effects of Sleep Deprivation and Adrenergic Inhibition on Glymphatic Flow in Humans
The project is aimed at identifying how the adrenergic antagonist 'carvedilol' modulates the effects of sleep deprivation in healthy volunteers. The study is a double-blind, randomized, placebo-controlled, cross-over study.
- Conditions
- Sleep Deprivation, Sleep Wake Disorders, Sleep
- Trial name
- NCT03576664
- Testing
- Carvedilol 25mg
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Sleep Deprivation
Effect of Nap on Daytime Functioning in Primary School Students
Previous studies showed that insufficient sleep has a negative impact on children's physical and psychological health. Napping was found to decrease sleepiness and improve daytime functioning in adults and adolescents.
- Trial name
- NCT04270539
- Testing
- Nap
- Where
- Hong Kong
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Critically Ill
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
The Hospital of the University of Pennsylvania's Medical ICU (MICU) is implementing a model of 24-hour intensivist staffing in September 2011.
- Trial name
- NCT01434823
- Testing
- Nocturnal coverage
- Where
- United States
- Volunteers
- 1,609 people
- Sponsor
- University of Pennsylvania
Sleep Deprivation
Evaluation of the Effect of Neurofeedback Targeting EEG Theta / Beta Activities on the Strengthening of Wakefulness Maintenance Capacities and Cognitive Performance.
Neurofeedback is a cognitive remediation technique that allows a subject to learn to regulate their cognitive and brain activity through information provided in real time about their brain activity, in particular…
- Trial name
- NEUROWAKE (NCT04591314)
- Testing
- Neurofeedback
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Nursing Caries, Pain, Postoperative
Effect of Foot Bath on Postoperative Sleep Quality and Pain
One of the most common problems in patients in the postoperative period is pain and the associated deterioration in sleep quality. Deterioration in sleep quality can cause pain to be perceived more severely.
- Conditions
- Nursing Caries, Pain, Postoperative, Sleep Deprivation
- Trial name
- NCT05705908
- Testing
- Hot Foot Bath 1, Hot Foot Bath 2
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Sleep Deprivation, Healthy Volunteers
Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex.
- Conditions
- Sleep Deprivation, Healthy Volunteers, Skeletal Muscle
- Trial name
- NCT03404427
- Testing
- Normal sleep night, Sleepless night
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Sleep Deprivation, Sleep
Effects of Napping in Sleep-Restricted Adolescents
To examine the neurobehavioural responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive performance, alertness, and mood.
- Trial name
- NCT02838095
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Depression, Involutional, Major Depresssion
Rapid Antidepressant Effects of Yohimbine in Major Depression
This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours.
- Trial name
- NCT00078715
- Testing
- Yohimbine hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Mental Health (NIMH)
Sleep, Sleep Deprivation
Effects of Sleep Deprivation on Blood Hormones and Inflammatory Status After Exercise Induced-muscle Damage
The aims of this study are examine the effects of sleep deprivation in muscle recovery after a maximum eccentric resistance exercise session performed on an isokinetic dynamometer (24 series of 10 repetitions).
- Trial name
- NCT02082600
- Testing
- Sleep deprivation, Normal sleep
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Sleep Deprivation
Effect of Sleep Restriction on Decision Making and Inflammation
hypothesis: sleep restriction in healthy subject trigger alteration of decision making associated with immuno-inflammatory changes inclusion criterias: healthy subjects, men, under 35 years, BMI<26, no sleep troubles…
- Trial name
- NCT01989741
- Testing
- Sleep restriction
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Cognitive Dysfunction, Sleep Deprivation
Effects of Partial Sleep Deprivation on Cognitive Function of Anesthesiologists
The purpose of this study was to evaluate differences in cognitive functions at baseline and following night shift at a trauma center among faculty anesthesiologists.
- Trial name
- sleep (NCT03784560)
- Testing
- The Psychomotor Vigilance Task (PVT), Epworth Sleepiness Scale, Karolinska sleeping scale
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Sleep Deprivation
Physiologic Effects of Sleep Restriction
Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms…
- Trial name
- NCT01433315
- Testing
- sleep restriction
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep Deprivation
Effects of Partial Sleep Deprivation on Cardiac Output During Cycling
The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50…
- Trial name
- NCT06679543
- Testing
- Partial sleep deprivation
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Critical Care, Sleep Quality
VR Integrated Into Multicomponent Interventions for Improving Sleep in ICU
Background: The patients who are admitted to ICUs mostly experience sleep disturbance. Seeking an effective strategy and integrating it into the daily routine is of clinical importance.
- Trial name
- NCT05518955
- Testing
- Virtual reality and eye mask
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Hsiao-Yean Chiu
Healthy
Effect of Sleep Extension in Prevention to Sleep Deprivation
The approach of a competition can be associated to a decrease in sleep duration and quality which can negatively impact athlete's performance and health (injury risk, fall, accident).
- Trial name
- SLEEPERF (NCT06928168)
- Testing
- Total sleep deprivation, partial sleep deprivation, Reproductibility
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sleep Deprivation
Combined Effects of Acute Sleep Restriction and Moderate Acceleration (+Gz) on Physiological and Behavioral Responses to High Mental Workload
Fighter pilots have to perform tasks requiring high mental workload during moderate-intensity acceleration phases (2 to 3G) that can last several minutes.
- Trial name
- CogPhyAero (NCT06017882)
- Testing
- Partial sleep deprivation
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Insomnia, Sleep Fragmentation
Suvorexant and Sleep/Delirium in ICU Patients
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit…
- Conditions
- Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
- Trial name
- NCT04092894
- Testing
- Suvorexant 20 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sleep, Sleep Deprivation
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep…
- Trial name
- NCT07085754
- Testing
- Sleep Deprivation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuhui Qiu
Depression, Unipolar
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
From 40 to 60% of patients with depression experience a rapid and significant improvement of mood with one night of sleep deprivation (SD). The neural mechanisms underlying this effect have not been elucidated.
- Trial name
- NCT03169543
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depression
Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression
40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL).
- Trial name
- NCT00291239
- Testing
- partial sleep deprivation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Zentrum für Integrative Psychiatrie