Clinical trials: Effectiveness
Caries
Effectiveness of an ICCMS™ Caries Management Program.
The aim of this study is to compare in schoolchildren the effectiveness of an updated caries management program based on the current caries paradigm with the ICCMS™ system (International Caries Classification and Management…
- Trial name
- NCT04676230
- Testing
- Experimental group, Control group
- Where
- Colombia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Relapsed/Refractory Multiple Myeloma (MM)
Study of Naive HBI0101 CAR-T Therapy in Relapsed/Refractory Multiple Myeloma
A Phase 1a/1b Open-Label Study with Dose Escalation and Expansion Phases to Evaluate Safety and Preliminary Efficacy of Naïve HBI0101 CART Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma.
- Trial name
- NCT07333430
- Testing
- Naive HBI0101 CAR-T
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Heart Transplantation
A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation
The purpose of the study is to compare the number of randomized participants in each treatment group who experience an acute rejection episode in the first 6 months after undergoing cardiac transplantation.
- Trial name
- NCT00048165
- Testing
- Daclizumab, Methylprednisolone, Mycophenolate mofetil
- Where
- 30 sites in United States, Canada and 2 more
- Volunteers
- 434 people
- Sponsor
- Hoffmann-La Roche
Fractures
Low-magnitude High-frequency Vibration Study on Fracture Rate in Community Elderly
Fragility fracture is common due to global aging problem, incurring huge healthcare expenditure. The occurrence of fragility fracture is usually caused by a fall incidence of an elderly with low bone quality and poor balancing…
- Trial name
- NCT00973167
- Testing
- Low-magnitude high-frequency vibration treatment
- Where
- China
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Essential Thrombocytopenia
Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in Adult Essential Thrombocythemia
Objectives: To compare the efficacy and safety in Adult patients (≥18 years) diagnosed as essential thrombocythemia treated with the Pegylated Interferon Alfa-2b vs. Interferon Alfa.
- Trial name
- NCT05395507
- Testing
- Recombinant Interferon Alpha, Pegylated interferon alfa-2b
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Asthma
Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma
This is a study designed to evaluate efficacy and safety of Benralizumab in reducing the Oral Corticosteroid (OCS) use in adult patients with severe asthma who are receiving OCS with or without additional asthma controller…
- Trial name
- PONENTE (NCT03557307)
- Testing
- Benralizumab
- Where
- 144 sites in United States, Argentina and 15 more
- Volunteers
- 598 people
- Sponsor
- AstraZeneca
Psychomotor Agitation
Four Interventions in the Management of Psychomotor Agitation, Safety and Efficacy Evaluation
This study aims to evaluate the efficacy and safety of four options of medications in the management of acute psychomotor agitation,or violence and aggression situations in health services.
- Trial name
- NCT01485692
- Testing
- haloperidol+promethazine, haloperidol + midazolam, olanzapine
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Congenital Myasthenic Syndrome
Efficacy of Albuterol in the Treatment of Congenital Myasthenic Syndromes
The study tests the notion that patients suffering from certain types of congenital myasthenic syndromes are benefitted by the use of Albuterol at doses used in clinical practice.
- Trial name
- NCT01203592
- Testing
- Albuterol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Asthma
Study of Efficacy and Safety of QAW039 When Added to Standard-of-care Asthma Therapy in Patients With Uncontrolled Asthma
A randomized, multicenter, double-blind, placebo- controlled parallel-group study to determine the efficacy and safety of QAW039, compared with placebo, when added to standard-of-care (SoC) asthma therapy in adult and adolescent…
- Trial name
- NCT03226392
- Testing
- QAW039
- Where
- 142 sites in United States, Brazil and 16 more
- Volunteers
- 704 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
A Twelve Week Study of Supervised Mouth Rinse and Flossing
The purpose of this study is to evaluate the efficacy of twice daily alcohol containing essential oil mouth rinse and brushing versus dental flossing and brushing under once daily supervision for the prevention and reduction of…
- Trial name
- NCT04696536
- Testing
- Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Referenced Toothbrush, 5% Hydroalcohol Mouth Rinse
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Multiple Sclerosis
An Individualized-health eLibrary App for People With Multiple Sclerosis
The purpose of this study is to assess the effectiveness after using a new individualized-health e-library app named SavvyHealth among people with multiple sclerosis.
- Trial name
- SavvyHealth (NCT05124600)
- Testing
- SavvyHealth
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Urbana-Champaign
Schizophrenia, Bipolar Disorder
App and Body Fat Scale in the Management of Overweight Patients
This study tests whether using a health app (Huawei Health) and a smart body fat scale can help overweight patients with schizophrenia or bipolar disorder lose weight and stay engaged in their health. What We're Testing: 1.
- Conditions
- Schizophrenia, Bipolar Disorder, Metabolic Syndrome, Overweight and Obesity
- Trial name
- NCT05866107
- Testing
- Effectiveness and Feasibility of Self-Monitoring for Weight Management in Individuals with Mental Disorders Using Digital Intervention ("SWIM" trial)
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Capital Medical University
Asthma
Efficacy and Safety of Ciclesonide Administered With or Without Different Spacers in Patients With Asthma (12 to 75 y) (BY9010/M1-145)
The aim of the present study is to investigate the efficacy and safety of ciclesonide on lung function and safety. Ciclesonide will be inhaled at one dose level once daily, using an inhaler device with or without spacer.
- Trial name
- NCT00163436
- Testing
- Ciclesonide
- Where
- 66 sites in Canada, France and 4 more
- Volunteers
- 450 people
- Sponsor
- AstraZeneca
Nonsmall Cell Lung Cancer
Evaluating the Efficacy and Safety of AI Localization Models in Multidisciplinary Team Care for NSCLC
The goal of this clinical trial is to evaluate the effectiveness and safety of a locally deployed artificial intelligence (AI) decision-support model in the multidisciplinary team (MDT) process for patients with non-small cell…
- Trial name
- NCT07626736
- Testing
- Treat Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wen-zhao ZHONG
Elastic Chains, Elastics
Effectiveness of Elastic Chains Versus Elastics in Maxillary Canine Retraction
This clinical study aimed to evaluate the effectiveness of Elastics and Elastic chains in maxillary canine retraction. Participants of this study were patients undergoing maxillary canine retraction after first premolar…
- Trial name
- CREST (NCT07141836)
- Testing
- Elastomeric chain, Elastics
- Where
- Yemen
- Volunteers
- 33 people
- Sponsor
- Sana'a University
Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection
Sulbactam-Durlobactam in CRAB Infection: A Real-World Cohort Study
This is a multicenter real-world observational cohort study designed to evaluate the effectiveness and safety of sulbactam-durlobactam in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections.
- Conditions
- Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection, Pneumonia, Sepsis
- Trial name
- SD-CRAB (NCT07601711)
- Testing
- Sulbactam-Durlobactam
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Provincial People's Hospital
Fibromyalgia
Efficacy of NAT-FM Treatment for Fibromyalgia
The main objective of this study is to analyse the efficacy of the NAT-FM multicomponent treatment program as coadjuvant of treatment-as-usual (TAU) compared to TAU alone.
- Trial name
- NAT-FM (NCT04190771)
- Testing
- TAU + multicomponent treatment NAT-FM, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 169 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hyper-low-density Lipoprotein (LDL) Cholesterolemia
A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia
A Multicenter, Open-label Study to assess the safety and efficacy of ETC-1002 at 180 mg administered for 52 weeks in patients with hyper-LDL cholesterolemia
- Trial name
- NCT05687071
- Testing
- 180mg of ETC-1002(bempedoic acid)
- Where
- Japan
- Volunteers
- 130 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Blepharitis
A Study to Evaluate the Clinical Efficacy and Safety of Tobradex® ST Compared to Azasite® in the Treatment of Subjects With Moderate to Severe Chronic Blepharitis
The purpose of this study is to evaluate the clinical efficacy and safety of Tobradex ST compared to AzaSite in the treatment of moderate to severe chronic blepharitis.
- Trial name
- NCT01102244
- Testing
- Tobradex ST, Azasite
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Alcon Research
CBD, Pain, Chronic
The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management
The investigators are looking to conduct a study looking at the effects of cannabidiol (CBD) from Hemp Oil in patients with Chronic pain, anxiety and insomnia.
- Conditions
- CBD, Pain, Chronic, Anxiety, Insomnia
- Trial name
- NCT04729244
- Testing
- CBD
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Advanced Pain and Rehab Specialists
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