Clinical trials: Effectiveness
Endometriosis, Pain
Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain
The goal of this research is to improve pain outcomes for the over 500K Canadian women, girls and gender-diverse individuals who are newly diagnosed with endometriosis each year.
- Trial name
- NCT06333353
- Testing
- Real RepetitiveTranscranial Magnetic Stimulation 5 sessions, Real RepetitiveTranscranial Magnetic Stimulation 10 sessions
- Where
- Canada
- Volunteers
- 152 people
- Sponsor
- University of Ottawa
Cancer, Malnutrition (Calorie)
Evaluation of Safety and Efficacy of Supportan® Drink
The goal of this clinical trial is to demonstrate safety and efficacy of Supportan® Drink
- Trial name
- NCT06902402
- Testing
- Supportan® Drink
- Where
- Taiwan
- Volunteers
- 135 people
- Sponsor
- Fresenius Kabi Taiwan Ltd.
Anemia
Ferumoxytol Versus Oral Iron in the Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease Patients
The study will evaluate the safety and efficacy of a new intravenously administered iron drug to treat anemia in patients with chronic kidney disease who are not on dialysis.
- Trial name
- NCT00255437
- Testing
- ferumoxytol or oral iron
- Where
- 13 sites in United States
- Volunteers
- 304 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Covid19
Comparison of Remdesivir Versus Lopinavir/ Ritonavir and Remdesivir Combination in COVID-19 Patients
Comparison outcomes of a large cohort of moderate and severe COVID-19 patients received remdesivir alone with patients who received remdesivir in combination with lopinavir/ ritonavir in addition to standard management.
- Trial name
- NCT04738045
- Testing
- Remdesivir, Lopinavir/ Ritonavir and Remdesivir combination
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ahmed Essam
Papulopustular Rosacea
A Safety and Efficacy Study to Evaluate Rosacea
To evaluate the safety, efficacy, and pharmacokinetic profile of ascending concentrations of the study medication compared with vehicle in subjects with rosacea.
- Trial name
- NCT03883945
- Testing
- AIV001, Vehicle
- Where
- United States
- Sponsor
- AiViva BioPharma, Inc.
Frailty
AllogeneiC Human Mesenchymal Stem Cells (hMSC) in Patients With Aging FRAilTy Via IntravenoUS Delivery
The purpose of this study is to look at the safety of treatment with stem cells in patients with Frailty.
- Trial name
- CRATUS (NCT02065245)
- Testing
- Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs), Penicillin/Streptomycin-Free Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Longeveron Inc.
Eclampsia
Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES):
This is a double blinded, placebo-controlled trial to determine if IV dexamethasone more quickly than placebo assists resolution of Posterior Reversible Encephalopathy Syndrome (PRES) encountered in eclamptic patients.
- Trial name
- PRESIDEX (NCT02027272)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Mississippi Medical Center
Hypertrophy of Masseter Muscle
Medytoxin® Treatment in Patients With Benign Masseteric Hypertrophy
This study design is A Randomized, Double-blind, Multi-center, Phase II Optimal Dose-finding Study to Determine the Safety and Efficacy of Meditoxin® in Subjects in Benign Masseteric Hypertrophy.
- Trial name
- NCT02292472
- Testing
- Botulinum Toxin Type A
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Medy-Tox
Polycystic Ovary Syndrome
Efficacy of Jianpi Qushi Huatan Decoction in the Treatment of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common reproductive disease associated with endocrine and metabolic disorders. Some studies have shown that Chinese herbal medicine is beneficial for PCOS, but the efficacy of Chinese herbal…
- Trial name
- NCT05976295
- Testing
- Jianpi Qushi Huatan Decoction
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Healthy Contact Lens Wearers
Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution
The purpose of this study is to determine if Alcon MPDS is safe and effective for silicone hydrogel and soft hydrogel contact lens wearers.
- Trial name
- NCT01341977
- Testing
- Alcon MPDS, ReNu Fresh MPS
- Where
- United States
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Enrichment With Meaning-generating Activities, Rehabilitation as Usual
Enrichment of Day Centers in Community-based Psychiatry
This RCT study addresses the topic of improving the possibilities for people with severe mental illness (SMI) to be engaged in meaningful daily occupations at community-based activity (CBA) centers.
- Trial name
- NCT01732575
- Testing
- Enrichment with meaning-generating activities
- Volunteers
- 107 people
- Sponsor
- Lund University
Covid19
Intramuscular and Intravenous VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19.
The COMET-TAIL main study evaluated efficacy, safety, and tolerability of IM sotrovimab versus IV sotrovimab in high-risk patients for the treatment of mild/moderate COVID-19.
- Trial name
- NCT04913675
- Testing
- sotrovimab
- Where
- 50 sites in United States, France and 1 more
- Volunteers
- 1,065 people
- Sponsor
- Vir Biotechnology, Inc.
Chronic Hepatitis C (CHC)
Efficacy and Safety of MP-424, Peginterferon Alfa-2a (PEG-IFN Alfa-2a), and Ribavirin(RBV) in Treatment-Naïve or Relapsed Hepatitis C
This study will evaluate the efficacy and safety of MP-424 with PEG-IFN Alfa-2a and RBV in patients with genotype 1 hepatitis C, who are naïve to its treatment or relapsed after previous treatment.
- Trial name
- NCT01753557
- Testing
- MP-424, RBV, PEG-IFN alfa-2a
- Where
- Japan
- Volunteers
- 54 people
- Sponsor
- Tanabe Pharma Corporation
Hypertension, Pulmonary
Safety and Efficacy of Terbogrel in Patients With Primary Pulmonary Hypertension
This study sought to determine whether terbogrel was an effective treatment for primary pulmonary hypertension (PPH) by comparing its efficacy and safety to that of placebo.
- Trial name
- NCT02223481
- Testing
- Terbogrel low dose, Terbogrel high dose
- Volunteers
- 71 people
- Sponsor
- Boehringer Ingelheim
Enterovirus Infection
Pleconaril Enteroviral Sepsis Syndrome
A common group of viruses that infect humans are enteroviruses. Enteroviruses produce illnesses in children which may range from very mild (summer colds) to severe (infections of the brain, liver, and heart).
- Trial name
- NCT00031512
- Testing
- Pleconaril
- Where
- 25 sites in United States, Canada
- Volunteers
- 61 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Drug Induced Liver Injury
Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial
To determine the efficacy of NAC to prevent clinically significant anti-TB drugs induced liver injury (AT-DILI).
- Conditions
- Tuberculosis, Drug Induced Liver Injury, Hepatitis
- Trial name
- NCT05738681
- Testing
- N acetyl cysteine
- Where
- Thailand
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypovolemic Shock
A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent
This protocol is designed to develop a novel first-in-class treatment for use in critical care and life-threatening condition of hypovolemic shock with unmet need and is of national interest.
- Trial name
- NCT05251181
- Testing
- Normal Saline, Centhaquine
- Volunteers
- 430 people
- Sponsor
- Pharmazz, Inc.
Liver Cancer, Sarcopenia
Effect of Sarcopenia on HCC After Lenvatinib and Anti-PD-1 Treatment
Sarcopenia is associated with the prognosis of HCC and cholangiocarcinoma. But there has been rare study focusing on the effect of sarcopenia on the prognosis of HCC treated with lenvatinib and anti-PD1.
- Trial name
- NCT05443230
- Testing
- gait speed; ct scan; grip strength and chair stand test
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Effect of Drug, Adverse Drug Event
Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation
A multi-center, prospective, randomized, double-blind, active-controlled, no-inferiority clinical trial conducted across 5 tertiary medical centers in China.
- Conditions
- Effect of Drug, Adverse Drug Event, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT06575530
- Testing
- Remimazolam Besylate, Dexmedetomidine Hydrochloride
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Short Bowel Syndrome
Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome
A new Enteric-Coated Cholestyramine (ECC) capsule has been developed to manage diarrhea associated with Short Bowel Syndrome (SBS) in adults.
- Trial name
- NCT04046328
- Testing
- Enteric-Coated Cholestyramine (ECC) Capsule
- Where
- 3 sites in Poland
- Volunteers
- 13 people
- Sponsor
- Pharmascience Inc.
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