Clinical trials: Effectiveness
Major Depressive Disorder, Treatment Resistant Depression
Open-Label Safety Study of AXS-05 in Subjects With Depression
An open-label, long-term, safety study of AXS-05 in patients with major depressive disorder (MDD), including treatment resistant depression.
- Conditions
- Major Depressive Disorder, Treatment Resistant Depression, Depression
- Trial name
- NCT04039022
- Testing
- AXS-05 (dextromethorphan and bupropion) oral tablets
- Where
- 51 sites in United States
- Volunteers
- 876 people
- Sponsor
- Axsome Therapeutics, Inc.
Halitosis
Efficacy of Glycine Powder Air-Polishing Combined With Scaling and Root Planing in the Treatment of Periodontitis and Halitosis
The aim of this clinical study was to evaluate the clinical efficacy of using perio flow adjunctively with mechanical instrumentation on periodontal parameters and halitosis.
- Trial name
- NCT03031756
- Testing
- glycine powder air-polishing (Air-Flows)Perio Powder, ultrasonic (Piezon Master 700; EMS, Nyon, Switzerland)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
COVID19 Pneumonia
Trial Evaluating Efficacy and Safety of Anticoagulation in Patients With COVID-19 Infection, Nested in the Corimmuno-19 Cohort
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent Covid-19 or infection with SARS-CoV-2 or therapeutic agent to…
- Trial name
- CORIMMUNO-COAG (NCT04344756)
- Testing
- Tinzaparin or unfractionated heparin
- Where
- 3 sites in France
- Volunteers
- 808 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoparathyroidism
Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in Adults
This clinical trial aims to evaluate the efficacy and safety of AMOR-1, consisting of Amorphous Calcium Carbonate (ACC) as the active drug substance, in treating hypocalcemia in adults with hypoparathyroidism.
- Trial name
- NCT06547151
- Testing
- AMOR-1, Crystalline Calcium Carbonate
- Where
- 9 sites in Israel
- Volunteers
- 62 people
- Sponsor
- Amorphical Ltd.
Diabetes Mellitus
Clinical Study on the Safety and Efficacy of Immunophenotyped Pancreatic Endocrine Organoid Bank in Treating Patients With T3c Diabetes
Islet cells are isolated from resected pancreatic tissue obtained from patients undergoing surgery, followed by ex vivo expansion and culture.
- Trial name
- NCT06991829
- Testing
- HLA-matched pancreatic endocrine organoids transplantation
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Shanghai Zhongshan Hospital
Relapse/Refractory Multiple Myeloma
Study of Panobinostat in Combination With Bortezomib and Dexamethasone in Japanese Patients With Relapsed/Refractory Multiple Myeloma
The purpose of this study was to evaluate the efficacy and safety of panobinostat in combination with bortezomib and dexamethasone in Japanese patients with relapsed/refractory multiple myeloma.
- Trial name
- NCT02290431
- Testing
- LBH589 (panobinostat), bortezomib, dexamethasone
- Where
- 20 sites in Japan
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Dysmenorrhea
Efficacy and Safety Study of NPC-01 to Treat Dysmenorrhea
The purpose of this study is to determine whether NPC-01 is effective in the treatment of dysmenorrhea.
- Trial name
- NCT01129102
- Testing
- NPC-01, IKH-01
- Volunteers
- 215 people
- Sponsor
- Nobelpharma
Covid19
Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 Serum in COVID-19 Patients
Reports of the use of plasma from convalescent patients and purified immunoglobulin preparations in respiratory infections by various viral agents and SARS-CoV-2 in severely ill patients suggest that specific neutralizing…
- Trial name
- SECR-01 (NCT04610502)
- Testing
- Administration of Equine immunoglobulin anti SARS-CoV-2
- Where
- 4 sites in Costa Rica
- Volunteers
- 26 people
- Sponsor
- Caja Costarricense de Seguro Social
Differentiated Thyroid Cancer, Thyroid Cancer
Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy
This study will be a multicentre prospective cohort study on TH-substitution after thyroid hormone withdrawal preceding radioiodine treatment.
- Conditions
- Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine, Liothyronine
- Trial name
- THRIVE (NCT06647602)
- Testing
- Euthyrox (levothyroxine), Cytomel (liothyronine)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Low Back Pain, Postural; Strain
Mézières Therapy in the UCAM's Athletes With Low Back Pain
The purpose of this research study focuses on the re-harmonization of the kinetic chains and posture based on spinal muscular atrophy and global stretching while trying to test the effectiveness of Mézières therapy on sports…
- Trial name
- NCT03849053
- Testing
- Mézières Therapy for Low back pain
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Social Behavior
Efficacy of the E-motional Training Program for Improving Social Cognition in People With Dual Pathology in a Clinical and Prison Environment
Drug use, substance-related disorders (SUD), other addictive behaviors, or, from a broader perspective, dual pathology, are problems of enormous socio-health impact that still require a great research effort to improve diagnostic…
- Trial name
- NCT06514937
- Testing
- Emotional Training
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Hypertension
Use of Ramipril and Felodipine Combination Therapy in Hypertension: An Effectiveness Study With Local Patients in Argentina
Primary: To assess effectiveness of Ramipril-Felodipine in hypertensive Argentinean patients Secondary: To assess tolerability of Ramipril-Felodipine in hypertensive Argentinean patients.
- Trial name
- RAFEHELP (NCT00507845)
- Testing
- Ramipril-Felodipine
- Where
- Argentina
- Volunteers
- 271 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Efficacy and Safety of Ivarmacitinib Monotherapy in the Treatment of csDMARDs-IR Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting small joints, with a global prevalence of 0.5%-1.0% and 0.42% in China (around 5 million patients, mostly female and over 55).
- Trial name
- NCT07452445
- Testing
- Ivarmacitinib
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Solid Tumors
Study to Evaluate the Effect of Age (Geriatric) and Kidney Function on the Safety, Efficacy and Pharmacokinetics of OctreoScan in Patients Who Have New or Recurrent Tumors
The objective of this study was to evaluate the effect of age (geriatric) and renal function on the safety, efficacy and pharmacokinetics of OctreoScan at the recommended clinical dose in this patient population.
- Trial name
- NCT00944372
- Testing
- Indium In-111 pentetreotide
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Mallinckrodt
Primary Aldosteronism, Hypertension
Adrenal Artery Ablation for Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common causes of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT03653845
- Testing
- Endovascular chemical Ablation of Adrenal Gland, Sequenced antihypertensvie drugs with titrated dosage
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Third Military Medical University
Malaria
Artemisinin Resistance In Malaria Treated With IV Artesunate
The spread of artemisinin resistant falciparum malaria presents new challenges to both the control and treatment of malaria. Loss of ring stage susceptibility to the artemisinins might jeopardize the use of parenteral artesunate…
- Trial name
- ARIMTIA (NCT02640495)
- Testing
- Intravenous Artesunate as part of standard medical practice
- Sponsor
- University of Oxford
Hepatocellular Carcinoma
Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma
Randomized, 2-arm, non-comparative, pilot study assessing the efficacy of cemiplimab with or without fianlimab after treatment with yttrium-90 (Y90).
- Trial name
- CLeAR (NCT07365839)
- Testing
- Arm 1 cemiplimab, Arm 2 cemiplimab and fianlimab
- Sponsor
- Virginia Commonwealth University
Chronic Obstructive Pulmonary Disease (COPD)
Tolerability/Safety and Efficacy of Inhaled AZD4818 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to see if treatment with AZD4818 for four weeks is tolerable, safe and effective in treating COPD and, if so, how it compares with placebo.
- Trial name
- TOP (NCT00629239)
- Testing
- AZD4818
- Where
- 12 sites in Denmark, Finland and 3 more
- Volunteers
- 65 people
- Sponsor
- AstraZeneca
Dry Skin, Xerosis Cutis
The Effectiveness of Herbal Creams Compared to Urea in Dry Skin Treatment
The goal of this Clinical trial is to Determine the effectiveness of a cream combining Gayo Arabica coffee bean extract and Aceh patchouli compared to urea cream for dry skin in Patients with dry skin, aged 18-65 years old who…
- Trial name
- NCT07360639
- Testing
- combination cream, control cream
- Where
- Indonesia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universitas Syiah Kuala
Advanced Liver Cancer
A Phase Ib/II Trial to Evaluate the Safety and Efficacy of QL1706 in Patients With Advanced Hepatocellular Carcinoma
This is a phase Ib/II trial to evaluate the safety, pharmacokinetics and preliminary efficacy of QL1706 or QL1604 combined with bevacizumab in patients with advanced hepatocellular carcinoma.
- Trial name
- NCT05603039
- Testing
- QL1706, QL1604, Bevacizumab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.