Clinical trials: Effectiveness
Anxiety, Depression / Major Depressive Disorder
The Effectiveness of a One-stop Electronic Clinic for Psychological Service (eClinic) in Hong Kong
With an increasing need for effective and accessible mental health services, telepsychology can be one promising solution to narrowing the gap between demand and supply.
- Conditions
- Anxiety, Depression / Major Depressive Disorder, Common Mental Disorder
- Trial name
- NCT07597967
- Testing
- Internet-based Unified Protocol (UP) Intervention
- Where
- Hong Kong
- Volunteers
- 420 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia, Relapsed or Refractory B-cell Non-hodgkin Lymphoma
CD19 Targeted Universal Chimeric Antigen Receptor T Cells Injection for CD19+ Refractory/Relapsed B-cell Malignancies
It is a single-arm, open-label clinical study to assess the safety and efficacy of the Anti-CD19 Universal CAR-T Cells injection for patients with CD19+ refractory/relapsed B cell acute lymphoblastic leukemia and B cell…
- Trial name
- NCT05105867
- Testing
- Anti-CD19 Universal CAR-T Cells injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Homozygous Familial Hypercholesterolemia
Study of ARO-ANG3 in Participants With Homozygous Familial Hypercholesterolemia (HOFH)
Participants with documented homozygous familial hypercholesterolemia (HoFH) who have provided informed consent will receive 2 open-label doses of ARO-ANG3 and be evaluated for safety and efficacy parameters through 36 weeks.
- Trial name
- Gateway (NCT05217667)
- Testing
- ARO-ANG 3 Injection
- Where
- 7 sites in United States, Australia and 2 more
- Volunteers
- 18 people
- Sponsor
- Arrowhead Pharmaceuticals
Visual Analogue Scale
Neural Therapy in Cesareans
In the management of pain after Caesarean section (C/S), opioid or nonsteroidal anti-inflammatory parenteral drugs are applied. These drugs are insufficient in some cases and may cause pain attacks during the day.
- Trial name
- NCT06999200
- Testing
- neural therapy
- Volunteers
- 156 people
- Sponsor
- Haseki Training and Research Hospital
Multiple Sclerosis (MS) Relapsing Remitting
A Multicenter Clinical Trial Evaluating the Efficacy and Safety of Taurine as an Adjunctive Therapy in Multiple Sclerosis
This multicenter, randomized, open-label clinical trial aims to evaluate the efficacy and safety of taurine as an adjunctive therapy to standard disease-modifying treatments (DMTs) in patients with multiple sclerosis (MS).
- Trial name
- NCT07263607
- Testing
- DMTs + taurine, DMTs
- Volunteers
- 80 people
- Sponsor
- Sichuan Academy of Medical Sciences
Asthma
Montelukast Asthmatic Smoker Study (0476-332)(COMPLETED)
This is a multicenter study to evaluate the efficacy and safety of MK0476 versus placebo in participants with chronic asthma who actively smoke cigarettes.
- Trial name
- NCT00284856
- Testing
- montelukast sodium, Comparator: fluticasone
- Volunteers
- 1,640 people
- Sponsor
- Organon and Co
CD7+ Acute Leukemia, CD7+ Lymphoma
Clinical Trial for the Safety and Efficacy of Anti-CD7 CAR-T Cell Therapy for Patients With Relapsed or Refractory CD7 Positive Hematological Malignancy
This is a prospective, open-label, single-center clinical trial. This study will evaluate the safety and efficacy of anti-CD7 CAR-T cells in the treatment of relapsed or refractory CD7 positive T-ALL/LBL, T-NHL and AML.
- Trial name
- NCT04599556
- Testing
- anti-CD7 CAR-T
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Zhejiang University
Signs and Symptoms, Physical Disorders
Safety/Effectiveness Study of a Single Session of Laying-on-of-hands in Various Settings in Japan
The purpose of this study is to determine the symptomatic changes after a single session of laying-on-of-hands in various settings, and to evaluate optimal conditions for the outcomes.
- Conditions
- Signs and Symptoms, Physical Disorders, Personal Satisfaction
- Trial name
- SELH (NCT01316029)
- Testing
- Okada Purifying Therapy
- Where
- Japan
- Volunteers
- 44,587 people, healthy volunteers welcome
- Sponsor
- MOA Health Science Foundation
Stroke
Feasibility of a Home Hazard Management Program for Malaysian Stroke Survivors
This quasi experimental design study aims to examine the feasibility and potential effectiveness of a home hazard management program to reduce the rate of falls and fear of falling among Malaysian community dwelling stroke…
- Trial name
- NCT04618029
- Testing
- Home Modification, Education
- Where
- 3 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Putra Malaysia
Attention Deficit Hyperactivity Disorder
The Safety and Efficacy of a Compound Natural Health Product in Children With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to investigate the use of a natural health product, as compared to placebo (an inactive substance), in managing the symptoms of ADHD.
- Trial name
- NCT01022229
- Testing
- Compound Natural Health Product
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Renal Cell Carcinoma, Urinary Bladder Neoplasms
Phase I/Ib Study of Pembrolizumab With Vorinostat for Patients With Advanced Renal or Urothelial Cell Carcinoma
Primary objective: To assess the early signals for anti-tumor activity (i.e. objective response rate, progression-free survival) of pembrolizumab in combination with vorinostat in patients with advanced prostate, renal or…
- Trial name
- NCT02619253
- Testing
- Pembrolizumab, Vorinostat
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Nabil Adra
Breast Neoplasm, Colorectal Neoplasm
Decision Aid Website in Helping to Make Decisions About Fertility in Participants With Cancer
This trial studies how well a decision aid website works in helping to make decisions about fertility in participants with cancer.
- Conditions
- Breast Neoplasm, Colorectal Neoplasm, Female Reproductive System Neoplasm, Health Care Provider
- Trial name
- NCT03141437
- Testing
- Best Practice, Educational Intervention, Internet-Based Intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Mass
Spot Compression Ultrasound Compared to Traditional Breast Ultrasound
The purpose of this study is to determine the efficacy of targeted breast ultrasound ("ultrasound in the grid") performed concurrently with diagnostic mammogram during breast compression with an open mammogram paddle in lesion…
- Trial name
- NCT07471672
- Testing
- Targeted ultrasound in the grid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Parkinson's Disease Psychosis
A Study of the Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis
This study will evaluate the safety and efficacy of two dose levels of pimavanserin (ACP-103) compared to placebo in patients with Parkinson's disease psychosis.
- Trial name
- NCT00477672
- Testing
- Pimavanserin tartrate (ACP-103)
- Where
- 78 sites in United States, Bulgaria and 5 more
- Volunteers
- 298 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Pulmonary Arterial Hypertension
Olaparib for PAH: a Pilot Study
The main OBJECTIVE of this proposal is to extend our preclinical findings on the role of DNA damage and poly(ADP-ribose) polymerases (PARP) inhibition as a therapy for a devastating disease, pulmonary arterial hypertension (PAH)…
- Trial name
- OPTION-p (NCT03251872)
- Testing
- Olaparib
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Laval University
Wrinkle, Pigment Skin
A Clinical Study to Assess the Safety and Effectiveness of Anti-Ageing and Skin Brightening Gel
This is a Randomized, Interventional, Prospective, Double Blind, Two Arm, Comparative, Parallel, Placebo-Controlled, Safety and Efficacy Study of Anti-Ageing and Skin Brightening Gel.
- Conditions
- Wrinkle, Pigment Skin, Aging
- Trial name
- NCT06123572
- Testing
- Anti-Ageing and Skin Brightening Gel
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Solid Tumors
QTX3034 in Patients With KRAS G12D Mutation
Phase 1 study to determine the safety and tolerability of QTX3034 as a single agent or in combination with cetuximab.
- Trial name
- NCT06227377
- Testing
- QTX3034, Cetuximab
- Where
- 14 sites in United States
- Volunteers
- 250 people
- Sponsor
- Quanta Therapeutics
Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling
Safety and Efficacy Analysis of Stent-assisted Coil Embolization in the Treatment of Acute Ruptured Intracranial Aneurysms in the Perioperative Period.
To determine the perioperative safety and efficacy of stent-assisted coil embolization of intracranial aneurysms in the acute phase.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling, Efficacy and Safety
- Trial name
- NCT07683377
- Testing
- Perform stent-assisted aneurysm embolization on patients who meet the enrollment criteria, and administer antiplatelet drugs postoperatively according to the established trial protocol.
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Tang-Du Hospital
Amyotrophic Lateral Sclerosis (ALS)
A Phase Ⅰ/Ⅱa Study of SNUG01 in Adult Subjects With ALS
The goal of this clinical trial is to evaluate the safety, tolerability and preliminary efficacy of SNUG01 in in adult subjects with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT07169175
- Testing
- SNUG01
- Where
- 4 sites in United States, China
- Volunteers
- 21 people
- Sponsor
- SineuGene Therapeutics Co., Ltd.
Aging
Efficacy of Pre-sleep or Post-exercise Protein During 12 Weeks of Resistance Exercise Training
The goal of this clinical trial is to compare the effects of protein consumption before sleep or immediately after exercise during 12 weeks of resistance exercise training in older adults.
- Trial name
- NCT05922475
- Testing
- Protein
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Florida State University
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