Clinical trials: Effectiveness
Crohn's Disease
Observational Study Evaluating the Effectiveness of Drug Concentration to Predict the Recapture of Response in Crohn's Disease Patients With Loss of Response ( PRADA )
This is a multi-center study that explores the relationship between recapture of response with escalation to weekly adalimumab and trough adalimumab concentration before escalation in patients experiencing lack of response (LOR).
- Trial name
- PRADA (NCT02896985)
- Where
- 24 sites in Canada
- Volunteers
- 98 people
- Sponsor
- AbbVie
Acute Myeloid Leukemia
Study of Intracellular Nucleotide Pools Determination as Biomarker of the Efficacy of the Induction Treatment in Acute Myeloid Leukemia
Treatment of acute myeloid leukemia (AML) consists in two main phases: induction and consolidation. Standard chemotherapy combination for induction treatment associates cytarabine (AraC), a nucleoside analog, and an anthracycline…
- Trial name
- NUCLARA (NCT03234985)
- Testing
- Biological analyses
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Neuromuscular Blocks
Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial
The investigators propose a single-center, assessor-Blinded, parallel group randomized trial to compare the efficacy of reversal of rocuronium induced neuromuscular blockade by sugammadex versus neostigmine in patients undergoing…
- Trial name
- NCT06136585
- Testing
- 2 mg/kg sugammadex, 0.07 mg/kg neostigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Diabetic Macular Edema
Safety and Efficacy of a New Treatment in Combination With Laser for Diabetic Macular Edema
This study will evaluate the safety and efficacy of the intravitreal implant of dexamethasone with laser treatment vs. laser treatment alone in patients with diabetic macular edema.
- Trial name
- NCT00464685
- Testing
- Dexamethasone, Laser Photocoagulation
- Where
- 2 sites in United States, Canada
- Volunteers
- 253 people
- Sponsor
- Allergan
Colorectal Cancer Metastatic
Evaluation of CTCs Combined With Tumor Marker Detection of Efficacy of Chemotherapy in mCRC
Evaluation of individual peripheral blood circulating tumor cells combined with tumor marker detection of efficacy of chemotherapy in patients with advanced colorectal cancer: A observational clinical trial
- Trial name
- NCT02948985
- Testing
- treated with FOLFIRI±cetuximab
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cystic Fibrosis
Video Game Exercise Effectiveness of a Domiciliary Pulmonary Rehabilitation Program in Cystic Fibrosis Patients
The aim of this study is to evaluate the efficacy of a long-term domiciliary exercise program using the Wii video game platform as a training modality in Cystic Fibrosis (CF) patients.
- Trial name
- NCT02552043
- Testing
- Nintendo Wii exercise program
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Universidad Autonoma de Madrid
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Physical Inactivity, Sedentary Behavior
Feasibility, Acceptability, and Efficacy of the Sleep Move Stand Study
The overarching goal for this project is to develop a service-learning program that provides students excellent hands on training and patients with an excellent service that advances their health and well-being.
- Conditions
- Physical Inactivity, Sedentary Behavior, Sleep, Cognitive Function
- Trial name
- SMS (NCT05498415)
- Testing
- Education, Health coaching, Activity Monitor
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hair Transplantation, Cicatricial Alopecia
Hair Transplantation in Cicatricial Alopecia
follicular unit extraction as a method of hair transplantation in cicatricial alopecia
- Trial name
- NCT04472715
- Testing
- follicular unit extarcation and platelet rich plasma
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Rheumatoid Arthritis
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- DREAM (NCT04529876)
- Testing
- Tofacitinib, Abatacept
- Where
- United States
- Volunteers
- 29,464 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Bronchiectasis
N- Acetylcysteine in Airway Clearance in Bronchiectasis
It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis.
- Trial name
- NCT07293884
- Testing
- N Acetyle cysteine given by IV injection, Nebulized N Acetyle cysteine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Solid Tumors
Phase 1 Study of IBR854 in Locally Advanced Or Metastatic Solid Tumors
This study is an open-label, phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of IBR854 cell injection in patients with unresectable, locally advanced, or metastatic solid tumors.
- Trial name
- NCT06001684
- Testing
- IBR854 Cell Injection
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Imbioray (Hangzhou) Biomedicine Co., Ltd.
Type 2 Diabetes
Gene Expression Profiles and Metformin Efficacy in Type 2 Diabetes
Our general aim is to investigate whether messenger RNA (mRNA) and/or microRNA (miRNA) expression profiles in white blood cells, predict metformin monotherapy efficacy in patients with type 2 diabetes.
- Trial name
- NCT01334684
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Retinopathy of Prematurity
Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial
The purpose is to assess whether the use of microdrop instillation of phenylephrine 1.67% and tropicamide 0.33% maintains mydriatic efficacy while presents an improved safety profile compared with standard drops of phenylephrine…
- Trial name
- NCT04623684
- Testing
- Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)], Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)]
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- Aristotle University Of Thessaloniki
Dry Eye, Eye Fatigue
A Randomized Controlled Trial to Evaluate the Safety and Efficacy of an Oral Supplement in Supporting Vision and Eye Health
This is a 4-week virtual randomized, triple-blinded, placebo-controlled clinical trial evaluating the safety and efficacy of Eye Empower, an oral supplement, in adults aged 45 or older experiencing dry eyes, irritation, and…
- Trial name
- NCT07123584
- Testing
- Eye Empower
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Premature Birth, Theory, Double Bind
The Meleis Theory on Postpartum Depression, Breastfeeding, and Maternal Self-Efficacy in Women Experiencing Preterm Birth
The aim of this study was to evaluate the effect of a nursing approach based on Meleis' Transition Theory on postpartum depression, maternal self-efficacy and breastfeeding self-efficacy in women who gave birth preterm.
- Conditions
- Premature Birth, Theory, Double Bind, Postpartum Depression, Breast Feeding
- Trial name
- NCT06250933
- Testing
- Postpartum Maternal Care and Premature Infant Care Training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Glioblastoma
Correlation Between Psychological Stress and Disease Progression in Newly Diagnosed Glioblastoma Patients
It is a single-center, prospective, observational，non-randomized study of newly diagnosed glioblastoma patients conducted in a tertiary hospital.
- Trial name
- NCT05515133
- Testing
- stressors
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Provincial People's Hospital
Atopic Dermatitis
Efficacy and Steroid Sparing Potential Study of DGLA Cream in Early Childhood Patients With Moderate to Severe Atopic Dermatitis
This study will investigate the steroid sparing potential of DS107E to vehicle in patients with moderate to severe atopic dermatitis.
- Trial name
- NCT03676933
- Testing
- DS107E, Vehicle, Hydrocortisone Butyrate 0.1% Cream
- Where
- Ireland
- Volunteers
- 5 people
- Sponsor
- DS Biopharma
Obesity
A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery.
The primary goal of the study is to determine if orlistat 60mg (Alli) is effective in helping patients achieve a required 10% weight loss goal prior to bariatric surgery.
- Trial name
- NCT01035333
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Albany College of Pharmacy and Health Sciences
Dementia, Alzheimer Disease
The Efficacy of Traditional Chinese Herbal Medicine for Dementia
The Clinical trial is a pilot study for treatment of Alzheimer dementia by traditional Chinese herbal medicine(TCM).
- Trial name
- NCT03838952
- Testing
- Herbal medicine
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
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