Clinical trials: Effectiveness
Solid Tumors
A Clinical Study of 9MW2821 Monotherapy or Combined With Other Anticancer Therapy in Advanced Solid Tumors
This study is a Phase Ib/ll, open-label, multicenter study designed to evaluate the safety and efficacy of 9MW2821 monotherapy or combined with other anticancer therapy in advanced solid tumors.
- Trial name
- NCT06947226
- Testing
- 9MW2821, Other anti-cancer therapy
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Polymyositis, Dermatomyositis
A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis
This was a Phase 2 randomized, double-blind, placebo-controlled, crossover, multicenter study to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of treatment with KZR-616 in patients…
- Trial name
- PRESIDIO (NCT04033926)
- Testing
- KZR-616
- Where
- 14 sites in United States, Czechia and 1 more
- Volunteers
- 25 people
- Sponsor
- Kezar Life Sciences, Inc.
Asthma; Eosinophilic
Dupilumab Efficacy on Bronchial Inflammation, Small Airways Disfunction and Mucous Secretion
Unicentric prospective real life study designed to analyse the efficacy of Dupilumab to reduce bronchial inflammation of asthma measured by inflammatory cell counts obtained in induced sputum and other related characteristics…
- Trial name
- DEBORA (NCT05787678)
- Testing
- Dupilumab
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Endodontic Working Length Determination
AI-Based Working Length Determination in Curved Root Canals
This study tests whether artificial intelligence (AI) can accurately measure the length of curved root canals from dental x-rays.
- Trial name
- AI-CURL (NCT07787078)
- Volunteers
- 200 people
- Sponsor
- Alanya Alaaddin Keykubat University
Substance-Related Disorders
GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1
Gamma hydroxybutyrate (GHB) is a powerful central nervous system depressant. The number of individuals seeking treatment for GHB abuse has been steadily increasing in the United States.
- Trial name
- NCT00123578
- Testing
- Lorazepam, Pentobarbital
- Where
- United States
- Sponsor
- University of California, Los Angeles
Onychomycosis of Toenails
Evaluation Study for the Efficacy and Safety of PinPointe FootLaser in Treatment for Onychomycosis
The purpose of this study is to assess the clinical efficacy and safety of the PinPointe Foot Laser device for the treatment of patients with onychomycosis who have been previously treated with oral Terbinafine and failed.
- Trial name
- NCT01920178
- Testing
- PinPointe Foot Laser
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cambridge Health Alliance
Hypercholesterolemia
Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.
The purpose of the study is to determine the efficacy of lapaquistat acetate, once daily (QD), taken with simvastatin on cholesterol levels in subjects with primary dyslipidemia
- Trial name
- NCT00256178
- Testing
- Lapaquistat acetate and simvastatin, Simvastatin
- Where
- 53 sites in Czechia, Estonia and 5 more
- Volunteers
- 411 people
- Sponsor
- Takeda
Urinary Incontinence
Athena Pelvic Muscle Trainer - DUETS Trial
The purpose of this study is to determine if the Athena Pelvic Muscle Trainer device effectively treats stress, urge or mixed incontinence in women by strengthening the pelvic floor muscles by collecting data from the patient on…
- Trial name
- DUETS (NCT01073878)
- Testing
- Athena Pelvic Muscle Trainer
- Where
- 97 sites in United States, Virgin Islands
- Volunteers
- 462 people
- Sponsor
- Athena Feminine Technologies, Inc.
Rectal Injury
A Study of TH-SC01 in the Treatment of Radiation-induced Rectal Injury
The purpose of this study is to evaluate the efficacy and safety of allogeneic umbilical cord mesenchymal stem cells in the treatment of radiation-induced rectal injury.
- Trial name
- NCT05939778
- Testing
- TH-SC01(Umbilical cord mesenchymal stem cells)
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Acute Lymphoblastic Leukemia(ALL)
C-CAR011 Treatment in Subjects With ALL After HSCT
This is a single-center, prospective clinical study evaluating safety and efficacy of C-CAR011 treatment in subjects with ALL after HSCT
- Trial name
- NCT03327285
- Testing
- C-CAR011
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Ankylosing Spondylitis
Study to Assess Change in Disease Activity and Adverse Events of RINVOQ in Adult Participants With Ankylosing Spondylitis in the Real-World Japan
Axial spondyloarthritis (axSpA), which encompasses radiographic axSpA (r-axSpA, also known as ankylosing spondylitis [AS]) is an immune-mediated inflammatory disease primarily affecting the axial skeleton.
- Trial name
- SELECT AXIS RW (NCT05609643)
- Where
- 61 sites in Japan
- Volunteers
- 69 people
- Sponsor
- AbbVie
Breast Cancer
Three Doses of TAS-108 to Treat Recurrent or Recurrent Inoperable Breast Cancer
This study is being done to find out how safe TAS-108 is and how well TAS-108 works on recurrent or recurrent inoperable breast cancer.
- Trial name
- NCT00166543
- Testing
- TAS-108
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- SRI International
Major Depressive Diorder, Early Life Trauma
Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse
The purpose of this clinical research study is to understand how effective and safe an investigational study drug called lumateperone is and whether it works to reduce the severity of depressive symptoms in adults with Major…
- Trial name
- ITI-ELA-MDD (NCT07369115)
- Testing
- Lumateperone 42 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Relapsing Multiple Sclerosis
Efficacy and Safety Study of Ozanimod in Relapsing Multiple Sclerosis
This study is a two-part trial consisting of Part A (see NCT01628393) and Part B, presented within this record. The primary objective of Part B is to assess whether the clinical efficacy of ozanimod (RPC1063) is superior to…
- Trial name
- RADIANCE (NCT02047734)
- Testing
- Ozanimod, Interferon beta-1a
- Where
- 299 sites in United States, Belarus and 19 more
- Volunteers
- 1,320 people
- Sponsor
- Celgene
Cervical Spondylosis
Upper Trapezius Stretching in Patients With Cervical Spondylosis
This study aims to investigate the effectiveness of upper trapezius stretching exercises on pain intensity, neck range of motion, and disability in patients with cervical spondylosis.
- Trial name
- NCT05920564
- Testing
- Upper fibers of trapezius stretching, Standard care
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ahram Canadian University
Dengue Fever With Warning Signs
Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs
Dengue Hemorrhagic Fever is a mosquito-borne viral disease endemic in the Philippines which caused multiple epidemics. Most points to the activation of the complement system secondary to humoral respond leading to cytokine…
- Trial name
- NCT05034809
- Testing
- Melatonin 20 MG
- Volunteers
- 140 people
- Sponsor
- Ilocos Training and Regional Medical Center
Postoperative Delirium, Cognitive Impairment
Predictive Efficacy of Ratio of Median Frequency to Spectral Edge Frequency Used in the Depth of Anaesthesia Monitoring on Post-operative Cognitive Functions
The primary objective of this observational study is to evaluate the effectiveness of preoperative anaesthesia depth monitoring parameters in predicting postoperative cognitive functions in non-cardiac adult patients.
- Trial name
- NCT06644209
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Ankara University
Fish Allergy, Food Allergy in Children
Fish Oral Immunotherapy in Hong Kong Children
At present there is no cure for food allergy. People with a food allergy need to avoid the food they are allergic to in order to stay safe, but we know that accidental exposure is common.
- Trial name
- NCT05590299
- Testing
- Fish oral immunotherapy (codfish)
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Diabetes
UCMSCs Combined With Allogeneic Islet Transplantation for the Treatment of Diabetes
The aim is to Investigate the safety and efficacy of Portal vein infusion Allogeneic Human umbilical cord mesenchymal stem cells combined with Allogeneic islet transplantation for the treatment of diabetes
- Trial name
- NCT06751199
- Testing
- human umbilical cord mesenchymal stem cells, allogeneic islet
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Difficult Airway, Difficult Airway Intubation
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety.
- Conditions
- Difficult Airway, Difficult Airway Intubation, Neonate
- Trial name
- SEALION (NCT06683599)
- Testing
- Apneic oxygenation
- Where
- 4 sites in Australia, Brazil and 2 more
- Volunteers
- 240 people
- Sponsor
- Vinícius C Quintão, MD, MSc, PhD
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.