Clinical trials: Effectiveness
Neuromyelitis Optica Spectrum Disorders
The Safety and Efficacy of NouvSoma001 in Neuromyelitis Optica Spectrum Disorders
This is a single-center, randomized, open-label, placebo-controlled, dose-escalation trial. The objective of this research is to evaluate the safety, tolerability, and efficacy of intrathecal administration of human-induced…
- Trial name
- NCT06620809
- Testing
- Extracellular vesicles derived from human-induced neural stem cells for intrathecal injection
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Tongji Hospital
Diabetic Foot Ulcer
Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)
This is a Phase 2a Multi-Center, Prospective, Randomized, Controlled Study aimed to evaluate the Safety and Efficacy of Topically Applied PEP-TISSEEL in Subjects with Diabetic Foot Ulcers (DFU)
- Trial name
- NCT06319287
- Testing
- PEP (Purified Exosome Product) / TISSEEL
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Rion Inc.
Urinary Tract Infection
Safety and Efficacy of PP4001 for the Treatment of Symptoms Associated With Uncomplicated Urinary Tract Infection
PP4001 is a medication not yet approved by the US FDA. This is a phase 2, multi-center, randomized, double-blind study of 3 doses of PP4001 versus placebo in the treatment of symptoms associated with uncomplicated urinary tract…
- Trial name
- NCT01406587
- Testing
- PP4001
- Where
- 25 sites in United States
- Volunteers
- 261 people
- Sponsor
- Pinnacle Pharmaceuticals, Inc.
Hypertensive Nephropathy, Self-management
Effectiveness of Implementation of a Patient-centered Self-management Program in Patients With Hypertensive Nephropathy
This study is a 2-years project. The year 1 project: to assess the effectiveness of implementation of the program in patients with HN.
- Conditions
- Hypertensive Nephropathy, Self-management, Self-efficacy, Mental Health Wellness 1
- Trial name
- NCT04633993
- Testing
- PCSMP
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Advanced Solid Tumors
KXV01 Injection in Patients With Advanced Solid Tumor (Including Osteosarcoma and Sarcoma)
This is a single center, single arm, open-label, dose escalation, phase 1 study to evaluate the safety, tolerability and preliminary efficacy of KXV01 TCR Lentinvivo for patients with advanced solid tumors.
- Trial name
- NCT07596693
- Testing
- KXV01 TCR Lentinvivo Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- TCRx Therapeutics Co.Ltd
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiac Diseases
Health Literacy As a Mediator Between Gender, Illness Identity, and Self-Efficacy
The goal of this observational study is to understand the role of health literacy in shaping the relationship between gender differences, illness identity, and self-efficacy in geriatric patients with cardiac diseases.
- Trial name
- NCT06707116
- Volunteers
- 100 people
- Sponsor
- Cairo University
Acute Respiratory Distress Syndrome
To Evaluate The Safety and Initial Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
To evaluate the safety and initial efficacy of STSA-1002 injection in patients with acute respiratory distress syndrome.
- Trial name
- NCT06038916
- Testing
- STSA-1002 Injection
- Where
- 30 sites in China
- Volunteers
- 47 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Nonasthmatic Eosinophilic Bronchitis
Efficacy and Safety of add-on Montelukast to Inhaled Budesonide in the Treatment of Nonasthmatic Eosinophilic Bronchitis
Hypothesis: Add-on therapy with oral montelukast (Mon) to inhaled budesonide (BUD) may achieve better control of cough caused by nonasthmatic eosinophilic bronchitis (NAEB) with faster reduction of airway eosinophilia.
- Trial name
- NAEB (NCT01121016)
- Testing
- Montelukast
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Guangzhou Medical University
Hepatitis C Virus Infection
Sofosbuvir/Velpatasvir Fixed-Dose Combination in HCV-Infected Adults Who Are Undergoing Liver Transplantation
The primary objectives of this study are to evaluate the antiviral efficacy, safety, and tolerability of sofosbuvir/velpatasvir (SOF/VEL) fixed-dose combination (FDC) in hepatitis C virus (HCV)-infected adults who are undergoing…
- Trial name
- NCT02728206
- Testing
- SOF/VEL
- Where
- New Zealand
- Volunteers
- 9 people
- Sponsor
- Gilead Sciences
Hypercholesterolemia, Dyslipidemias
A Study to Evaluate the Effectiveness and Safety of Fixed-Dose Combination of Pitavastatin/ Ezetimibe
The objective of this study is to evaluate the effectiveness and safety of Pitavastatin/Ezetimibe FDC in patients with hypercholesterolemia.
- Trial name
- PIVOTAL (NCT07083206)
- Where
- South Korea
- Volunteers
- 4,500 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Dry Eye Disease (DED)
Clinical Efficacy and Molecular Dynamics of Quantum Molecular Resonance (QMR) Electrotherapy in Dry Eye Management
This project aims to investigate the clinical efficacy and molecular mechanisms of Quantum Molecular Resonance (QMR) electrotherapy in the management of dry eye disease (DED).
- Trial name
- NCT06955806
- Testing
- The Rexon-Eye, an electrotherapy device utilizing Quantum Molecular Resonance (QMR) technology
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Peripheral Artery Disease, Peripheral Vascular Disease
Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System
This is a clinical study of a new self-expanding stent (FlexStent®) designed specifically to cope with the extreme demands of the superficial femoral artery (SFA)/proximal popliteal artery.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Disease, Vascular Disease, Cardiovascular Diseases
- Trial name
- OPEN (NCT01355406)
- Testing
- FlexStent® Femoropopliteal Self Expanding Stent System
- Where
- 38 sites in United States, Belgium
- Volunteers
- 257 people
- Sponsor
- Cordis US Corp.
Asymptomatic Bacteriuria, Antibiotic Prophylaxis
Effectiveness of Three Times of Starting Antibiotic Prophylaxis in Patients With Asymptomatic Bacteriuria.
Asymptomatic bacteriuria (AB) is the isolation of a bacterium in a sample of urine appropriately collected from a person who does not have signs or symptoms of urinary infection.
- Trial name
- NCT03269604
- Testing
- Prophylactic antibiotic during five days previous to the procedure, Prophylactic antibiotic during three days previous to the procedure, Only a single dose of Prophylactic antibiotic
- Where
- Colombia
- Volunteers
- 456 people
- Sponsor
- Jorge Andres Ramos Castaneda
Type 2 Diabetes, Patient Engagement
The Effect of The Personalized Patient Engagement Plan on Diabetes Management
This study evaluates the effect of Personalized Patient Engagement Plan on diabetes management in patients with at least six months of Type-2 Diabetes.
- Conditions
- Type 2 Diabetes, Patient Engagement, Self Efficacy, Adherence, Patient
- Trial name
- NCT04256304
- Testing
- PHEinAction-Personalized Patient Engagement Plan
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Hacettepe University
Myopia
Contact Lens in Pediatrics (CLIP) in an Asian Population Study
To evaluate the safety, efficacy and physiological performance of daily disposable spherical and toric soft contact lenses in a vision-corrected population of children ages 8-11 years of age.
- Trial name
- CLIP (NCT00473304)
- Testing
- Johnson&Johnson Acuevue daily disposable lenses
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
HIV-1-Infection
Study of Oral Weekly Lepetegravir (Formerly GS-1720) and Lenacapavir Pacfosacil (Formerly GS-4182) Versus Biktarvy in People With HIV-1 Who Are Virologically Suppressed
The goal of this clinical study is to learn more about the experimental drugs lepetegravir and lenacapavir pacfosacil; to compare the combination of lepetegravir and lenacapavir pacfosacil with the current standard-of-care…
- Trial name
- WONDERS1 (NCT06544733)
- Testing
- Lepetegravir, Lenacapavir pacfosacil, Bictegravir/emtricitabine/tenofovir alafenamide
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 675 people
- Sponsor
- Gilead Sciences
Scabies
Evaluating Pediatric Ivermectin in Children Under 15 kg (EPIC-15)
The EPIC-15 trial will evaluate the safety, pharmacokinetics, acceptability, and efficacy of pediatric ivermectin (CHILD-IVITAB) in scabies infected children weighing 5 to less than 15 kg.
- Trial name
- EPIC-15 (NCT06404333)
- Testing
- CHILD-IVITAB
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- University of Oxford
Lower Limb Amputation, Prosthesis Users
Dual-Task Balance Training in Traumatic Lower-Limb Prosthesis Users
This randomized controlled trial will evaluate the effectiveness of dual-task balance training on balance, mobility, and mental health among traumatic lower-limb prosthesis users in the Gaza Strip.
- Conditions
- Lower Limb Amputation, Prosthesis Users, Balance Impairment, Mobility Limitations
- Trial name
- DTBT-LLA (NCT07706452)
- Testing
- Dual-Task Balance Training, Standard Rehabilitation
- Where
- Palestinian Territories
- Volunteers
- 63 people
- Sponsor
- Al-Azhar University - Gaza
Induction of Labor Affected Fetus / Newborn
Cervical Ripening in Obese Women: Efficacy of 25 mcg Versus 50 mcg of Misoprostol
This is a prospective clinical trial to determine if 50 mcg versus 25 mcg po every four hours of misoprostol has improved efficacy and similar safety in obese women undergoing cesarean section.
- Trial name
- NCT03748147
- Testing
- Misoprostol
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
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