Clinical trials: Effects of Chemotherapy
Chemotherapy Side Effects, Taste, Altered
Taste Alterations Study
The main questions it aims to answer are: 1. Does completing a standard assessment increase the detection of chemotherapy induced taste changes compared with usual care (no assessment)? What TA are experienced? Are there any…
- Trial name
- TAS (NCT06669416)
- Testing
- Taste Alteration Self-Assessment, Taste Alternation Self-Management
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Wake Forest University Health Sciences
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With Lamotrigine
This study will help determine the tolerability and efficacy of the mood-stabilizing anticonvulsant lamotrigine in youth with alcohol use disorder.
- Trial name
- NCT04770493
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Anemia, Neoplasms
A Study to Evaluate the Safety and Effectiveness of Epoetin Alfa Versus Placebo in Patients With Persistent Anemia as a Result of Cancer Treatment With Cisplatin, a Platinum-containing Chemotherapy Drug
The purpose of this study is to evaluate the safety and effectiveness of epoetin alfa versus placebo in the treatment of persistent anemia caused by advanced cancer and aggressive cisplatin chemotherapy.
- Trial name
- NCT00269997
- Testing
- epoetin alfa
- Volunteers
- 72 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Neoplasms, Colorectal, Neoplasm Metastasis
A Longitudinal Study of Colorectal Cancer Patients With Metastatic Disease in Middle-Norway
The main objective is to provide original research results that may change clinical practice related to metastatic colorectal cancer.
- Trial name
- NCT02395224
- Testing
- cancer treatment and follow-up according to current regional and national guidelines
- Where
- 7 sites in Norway
- Volunteers
- 354 people
- Sponsor
- Norwegian University of Science and Technology
Herpes Zoster, Neuralgia
NGX-4010 for the Treatment of Postherpetic Neuralgia
The purpose of the study is determine if an investigational drug, NGX-4010 (high-concentration capsaicin dermal patches) is effective in treating pain associated with post-herpetic neuralgia (PHN).
- Conditions
- Herpes Zoster, Neuralgia, Pain, Peripheral Nervous System Diseases
- Trial name
- NCT00061776
- Testing
- Capsaicin Dermal Patch
- Where
- 28 sites in United States
- Volunteers
- 300 people
- Sponsor
- NeurogesX
Lymphoma, Cancer
Feasibility of Intermittent Fasting During Chemotherapy
The goal of this randomized controlled parallel group trial is to examine if fasting before and after chemotherapy is safe, feasible and acceptable.
- Conditions
- Lymphoma, Cancer, Fasting
- Trial name
- FasteStudien (NCT06645093)
- Testing
- Fasting
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Chemotherapy Effect, Oncology
Modified Cephalica Venous Access Port Implantation
As long term totally implantable central venous access (TIVAPS) was increasingly needed in cancer patient, some modified techniques were introduced to improved the outcome and safety of the port implantation.
- Trial name
- NCT04348487
- Testing
- Modified cephalica venous access
- Where
- Indonesia
- Volunteers
- 3 people
- Sponsor
- Udayana University
Nausea and Vomiting, Aromatherapy
Effect of Inhaled Aromatherapy on Chemo-Induced Nausea Vomiting (NCVI): CINVAROM (Chemotherapy Induced Nausea Vomiting and AROMatherapy)
The investigator wish to provide a blend of two essential oils with comparable antiemetic properties; Peppermint essential oil (Mentha x Piperita) and lemon tree essential oil (Citrus Limon).
- Conditions
- Nausea and Vomiting, Aromatherapy, Essential Oil, Suportive Care
- Trial name
- CINVAROM (NCT04560114)
- Testing
- Essential oils
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Francois Baclesse
Colorectal Neoplasms Malignant, Minimal Residual Disease
Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II-III
This trial has been designed to prove the feasibility of using liquid biopsy detection of minimal residual disease (MRD) to guide the postsurgical clinical management of early colon cancer patients.
- Conditions
- Colorectal Neoplasms Malignant, Minimal Residual Disease, Circulating Tumor Cell
- Trial name
- NCT07821333
- Testing
- FOLFOXIRI, CAPOX
- Where
- 7 sites in Spain
- Volunteers
- 45 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Treatment Outcome
Vortioxetine (Lu AA21004) 10 and 20 mg for Treatment of Major Depressive Disorder With Sexual Dysfunction
The purpose of this study is to evaluate the effects of Vortioxetine (Lu AA21004), once daily (QD), compared with escitalopram on sexual functioning.
- Trial name
- NCT01364649
- Testing
- Vortioxetine, Escitalopram
- Where
- 62 sites in United States, Canada
- Volunteers
- 447 people
- Sponsor
- Takeda
Colo-rectal Cancer, Neuropathy;Peripheral
Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer
This study aims to: Evaluate the possible protective effect of pentoxifylline against oxaliplatin induced peripheral neuropathy and chemotherapy induced mucositis in patients with stage II and stage III colorectal cancer.
- Conditions
- Colo-rectal Cancer, Neuropathy;Peripheral, Mucositis
- Trial name
- NCT05590117
- Testing
- Pentoxifylline, FOLFOX-6 regimen
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Tanta University
Non-small Cell Lung Cancer, Esophageal Cancer
Radiation-induced Toxicity of the Heart
Late side effects in radio(chemo)therapy [R(CH)T] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic…
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Breast Cancer Female
- Trial name
- CorTox (NCT06986291)
- Testing
- Imaging and biomarkers
- Where
- Germany
- Volunteers
- 325 people
- Sponsor
- Technische Universität Dresden
Unspecified Adult Solid Tumor, Protocol Specific, Weight Changes
Oxandrolone Compared With Megestrol in Preventing Weight Loss in Patients Receiving Chemotherapy for Cancer
RATIONALE: Oxandrolone and megestrol may help prevent weight loss and improve quality of life in patients with cancer. It is not yet known whether oxandrolone is more effective than megestrol in preventing weight loss and…
- Trial name
- NCT00070148
- Testing
- Megestrol Acetate, Oxandrolone 20 mg
- Where
- 20 sites in United States
- Volunteers
- 155 people
- Sponsor
- Wake Forest University Health Sciences
Healthy Volunteers
A Study of the Interaction of Other Drugs With TAK-279 in Healthy Adults
The main aim of this study is to find out how several doses of TAK-279 affects the body of healthy adults and processes midazolam and repaglinide (pharmacokinetics or PK).
- Trial name
- NCT06290050
- Testing
- Midazolam, Repaglinide, TAK-279
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Takeda
Chemotherapy Induced Nausea and Vomiting
Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
Chemotherapy induced nausea and vomiting (CINV) is one of the few mostly observed distressing toxicity of cancer treatment. It can occur up to 90% in case of highly emetogenic chemotherapy use.
- Trial name
- Aprepitant (NCT01402024)
- Testing
- Aprepitant
- Where
- India
- Volunteers
- 96 people
- Sponsor
- All India Institute of Medical Sciences
Colon Cancer
Synergistic Anti-tumor Effect of ChangTai Keli for Colon Cancer Patients
The aim of this study is to evaluate the synergistic anti-tumor effect of ChangTai Keli based on chemotherapy for colon cancer patients by a randomized, parallel-group, double-blind, multicenter clinical study.
- Trial name
- NCT02510118
- Testing
- mFOLFOX6, XELOX, ChangTai Keli
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Nanjing NingQi Medicine Science and Technology Co., Ltd.
Diabetes Mellitus, Type 2
Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus
The aim of this study was to evaluate the effect of propolis or metformin on glycemic control in patients with type 2 diabetes mellitus without pharmacological treatment.
- Trial name
- NCT03416127
- Testing
- Propolis, Metformin
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- University of Guadalajara
Epilepsy
Effect of Epilepsy and Antiepileptic Drug Therapy on Gastric Motility and Emptying With Point-Of-Care Gastric Ultrasound
People with epilepsy often need surgery, but it is not fully known whether their stomachs empty food and liquids at the same rate as people without epilepsy.
- Trial name
- NCT07421661
- Testing
- Gastric Ultrasound
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lung Cancer, Pulmonary Complications
S0229, Pulmonary Rehabilitation Education w/wo Exercise Training in Improving Physical Function in Patients Who Are Undergoing Chemo & RT for Locally Advanced Lung Cancer
RATIONALE: Pulmonary rehabilitation education and exercise training may improve physical function and quality of life in patients who are receiving treatment for lung cancer.
- Trial name
- NCT00090961
- Testing
- educational intervention, supervised exercise program
- Where
- 60 sites in United States
- Volunteers
- 2 people
- Sponsor
- SWOG Cancer Research Network
Pain, Nausea With Vomiting Chemotherapy-Induced
The Effect of Acupressure on Pain, Nausea-Vomiting, and Mental Well-Being in Oncology Patients
The goal of this clinical trial is to compare the effect of self acupressure and acupressure applied by therapists on pain, nausea-vomiting, and mental well-being in oncology patients.
- Conditions
- Pain, Nausea With Vomiting Chemotherapy-Induced, Mental Health Wellness 1
- Trial name
- NCT05898880
- Testing
- Self-acupressure, Acupressure by therapists, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Mersin University