Clinical trials: Effects of Chemotherapy
Triple-Negative Breast Cancer (TNBC), Neoadjuvant Chemotherapy
Evaluating Bemotuzumab to Improve the Efficacy of Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer (TNBC)
Evaluating Bemotuzumab to improve the efficacy of neoadjuvant chemotherapy for Triple-Negative Breast Cancer (TNBC)
- Conditions
- Triple-Negative Breast Cancer (TNBC), Neoadjuvant Chemotherapy, Chemotherapy Effects
- Trial name
- NCT06975644
- Testing
- nab-paclitaxel, carboplatin, and bemotuzumab, epirubicin, cyclophosphamide, and bemotuzumab
- Volunteers
- 55 people
- Sponsor
- Zhejiang Provincial People's Hospital
Solid Tumor, Adult, Solid Tumor, Childhood
Evaluation of the Impact of Chemotherapy on Body Odor in Adolescents and Young Adults in Oncology
The appearance of unpleasant body odors in adolescent Young adult (aya) wille be evaluated undergoing chemotherapy
- Conditions
- Solid Tumor, Adult, Solid Tumor, Childhood, Chemotherapy Effect
- Trial name
- ODORAJA (NCT04899505)
- Testing
- Evaluation on appearance of unpleasant body odors
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Institut Curie
Locally Advanced Pancreatic Cancer, Borderline Resectable Pancreatic Cancer
A New Clinical Pathway for Personalized Management of Borderline Resectable and Locally Advanced Pancreatic Cancer
NORPACT-3 is a nationwide, Norwegian single arm prospective study that evaluates the resectability rates and survival in patients with borderline resectable and locally advanced pancreatic cancer who received primary…
- Conditions
- Locally Advanced Pancreatic Cancer, Borderline Resectable Pancreatic Cancer, Pancreatectomy, Chemotherapy Effect
- Trial name
- NORPACT-3 (NCT06944587)
- Testing
- Chemotherapy, Radiology, Pancreatectomy
- Where
- 5 sites in Norway
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Distress, Cancer
POEM (Practice Of Embracing Each Moment) STUDY
A cancer diagnosis is extremely stressful, emotionally challenging, and often life-altering for both patients and their loved ones.
- Conditions
- Distress, Cancer, Chemotherapy Effect
- Trial name
- POEM (NCT03078608)
- Testing
- Mindfulness meditation program (administered via mobile app), Progressive muscle relaxation (via mobile app)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Rectal Neoplasms, Chemotherapy Effect
Clinical Relevance of Major Pathologic Regression for Locally Advanced Rectal Cancer
We evaluated all related clinical and pathologic data of patients with Locally Advanced Rectal Cancer following Neoadjuvant Chemoradiotherapy, including the pathologic regression grading, and other histopathologic…
- Trial name
- NCT06879197
- Volunteers
- 1,187 people
- Sponsor
- Yanhong Deng
Chemotherapy Effect, G-CHOP Chemotherapy
Multidisciplinary Care Program to Secure MEdication Therapy for HematoLOgy Patients Receiving Injectable Anticancer Drugs
Several experiences of multidisciplinary care pathways associating oncologists, pharmacists and nurses have been reported for cancer patients, with positive results on medication management safety, reduction of Drug-Related…
- Conditions
- Chemotherapy Effect, G-CHOP Chemotherapy, R-CHOP Chemotherapy
- Trial name
- Melodia (NCT05350930)
- Testing
- Assessment of patient satisfaction regarding tele-consultation, Literacy questionnaire, Collection of socio-demographic characteristics
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Circulating Tumor Cell, Nasopharyngeal Carcinoma
Detecting Chemosensitivity and Predicting Treatmemt Efficacy With CTCs in mNPC
The prospective observational clinical study will recruit 50 metastatic nasopharyngeal carcinoma (mNPC) patients, detecting patient's chemosensitivity with the circulating tumor cells (CTCs) from peripheral blood and prdicting…
- Conditions
- Circulating Tumor Cell, Nasopharyngeal Carcinoma, Distant Metastases.Clinical, Effects of Chemotherapy
- Trial name
- NCT04544969
- Testing
- cisplatin-based chemotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Chemotherapy Side Effects, Social Media
The Impact of Social Media-delivered Chemotherapy Side Effects Education for Breast Cancer Patients Receiving Chemotherapy
The goal of this clinical trial is to learn if a standardized pharmacists-provided education module by social media can improve patients' knowledge of chemotherapy-related side effects.
- Conditions
- Chemotherapy Side Effects, Social Media, Education of Patients
- Trial name
- NCT06791603
- Testing
- Standardized chemotherapy education + video
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Bone Tumor, Cancer of Bone
Endoprosthesis Metal Toxicity Study
The purpose of this research is to investigate whether patients who previously had endoprosthesis surgery experience memory, thinking, or heart problems. It will also help determine how often these problems occur.
- Conditions
- Bone Tumor, Cancer of Bone, Heart Diseases, Cognitive Impairment
- Trial name
- NCT04755140
- Testing
- Questionnaires, Interviews, Blood Test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Resectable Pancreatic Cancer, Neoadjuvant Chemotherapy
NeoFOL-R Trial (Perioperative Versus Adjuvnat FOLFIRINOX in Resectable Pancreatic Cancer)
Rationale: Adjuvant chemotherapy after surgery significantly improved the survival of PC patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Resectable Pancreatic Cancer, Neoadjuvant Chemotherapy, Effects of Chemotherapy
- Trial name
- NCT05529940
- Testing
- Folfirinox
- Where
- 2 sites in South Korea
- Volunteers
- 609 people
- Sponsor
- Seoul National University Hospital
Cancer, Chemotherapy Effect
Virtual Support, Real Impact: Effectiveness of Tele-nursing in Alleviating Chemotherapy Symptoms Among Cancer Patients
This quasi-experimental study evaluated a tele-nursing educational program's impact on improving the quality of life and managing chemotherapy-related symptoms in 74 adult cancer patients at Mansoura University Hospital in Egypt.
- Conditions
- Cancer, Chemotherapy Effect, Quality of Life (QOL)
- Trial name
- NCT06702982
- Testing
- tele-nursing educational program
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Helwan University
Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect
Neoadjuvant Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer (NORPACT-2)
This is a Norwegian prospective observational study that evaluates the resectability rate in patients with borderline resectable and locally advanced pancreatic cancer who received neoadjuvant chemotherapy in a population based…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect, Borderline Resectable Pancreatic Adenocarcinoma, Pancreatectomy
- Trial name
- NCT04423731
- Testing
- Folfirinox
- Where
- Norway
- Volunteers
- 251 people
- Sponsor
- Oslo University Hospital
Chemotherapy Effect, Dental Caries
Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10
To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors.
- Conditions
- Chemotherapy Effect, Dental Caries, Malocclusion, Childhood Cancer
- Trial name
- NCT06517927
- Testing
- Clinical and radiographic dental examination
- Where
- Belgium
- Volunteers
- 142 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Neuroendocrine Tumors, Frailty
Metronomic Temozolomide in Unfit NENs Patients Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms (NENs): MeTe Study
Study design and rationale: Neuroendocrine neoplasms (NENs ) represent a heterogeneous group of malignancies, which differ in terms of behavio r and prognosis.
- Conditions
- Neuroendocrine Tumors, Frailty, Chemotherapy Effect
- Trial name
- MeTe (NCT05554003)
- Testing
- Temozolomide capsule
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- European Institute of Oncology
T-Cell Dysfunction, Chemotherapy Effect
Studying the Senescent T Cell Features and Its Relationship with the Chemotherapy Efficacy in Young TNBC
The goal of this observational study is to learn about the features of senescent T lymphocytes induced by chemotherapy and its relationship with the efficacy of neoadjuvant chemotherapy in young triple-negative breast cancer…
- Conditions
- T-Cell Dysfunction, Chemotherapy Effect, Adverse Events
- Trial name
- STFREiYTNBC (NCT06684054)
- Testing
- docetaxel, anthracycline, cyclophosphamide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Colon Cancer, Rectal Cancer
Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer
The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the…
- Conditions
- Colon Cancer, Rectal Cancer, Chemotherapy Effect, PTC
- Trial name
- NCT05424692
- Testing
- 5-fluorouracil + formyltetrahydrofolate/Oxaliplatin + 5-fluorouracil + formyltetrahydrofolate/Irinotecan + 5-fluorouracil + formyltetrahydrofolate/Cetuximab + 5-fluorouracil + formyltetrahydrofolate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Peripheral Neuropathy, Chemotherapy Effect
Task-oriented Training on Hand Function in Taxanes-induced Peripheral Neuropathy
Chemotherapy based on taxanes is commonly used to treat breast cancer. However, chemotherapy-induced peripheral neuropathy (CIPN), a side effect of taxanes, impairs a patient's grip strength, hand dexterity, and upper extremity…
- Conditions
- Peripheral Neuropathy, Chemotherapy Effect, Hand Function
- Trial name
- NCT06632626
- Testing
- Task oriented training exercises, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Aplasia, Chemotherapy Effect
HYPNONAG : Therapeutic Communication Versus Traditional Method for Naso-gastric Intubation in Haematology
Caloric intake is a determining factor in patients with hematological malignancies and hospitalized for prolonged aplasia following chemotherapy.
- Trial name
- HYPNONAG (NCT05790733)
- Testing
- Standard intubation, Hypnosis
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- Rennes University Hospital
AML, Adult, Chemotherapy Effect
Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML
This research is being done to assess the therapeutic efficacy and safety of a promising (venetoclax and decitabine) versus conventional "7+3"chemotherapy in induction young patients with acute myeloid leukemia.
- Trial name
- NCT05177731
- Testing
- Venetoclax, Decitabine for Injection, Cytarabine
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Chen Suning
Gastric Adenocarcinoma, Cancer Metastatic
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Gastric Carcinomatosis. Phase II Randomized Study
Peritoneal metastasis is a common pattern in advanced gastric cancer leading to a terminal condition in a very short time. Whatever recent progress regarding systemic chemotherapy using multi drugs association median survival is…
- Conditions
- Gastric Adenocarcinoma, Cancer Metastatic, Chemotherapy Effect
- Trial name
- PIPAC EstoK 01 (NCT04065139)
- Testing
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC), Standard chemotherapy
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris