Clinical trials: Effects of Chemotherapy
Breast Cancer, Colorectal Cancer
The ONE-MIND Study: Evaluating the Efficacy of Online Mindfulness-Based Cancer Recovery During Chemotherapy Treatment
Background: Chemotherapy treatment (CT) can have burdensome side effects such as fatigue, nausea-vomiting, and sleep problems that can significantly affect patients' quality of life.
- Conditions
- Breast Cancer, Colorectal Cancer, Chemotherapy Effect
- Trial name
- NCT03484000
- Testing
- Online Mindfulness Based Cancer Recovery (MBCR)
- Where
- Canada
- Volunteers
- 178 people
- Sponsor
- University of Calgary
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Chemotherapy Effect
Skin Sensitivity Acupuncture and Kinesiotherapy on Breast Cancer Patients Subject to Chemotherapy With Taxans
Objective: to compare different therapies employing acupuncture needles, silicon pellets and kinesiotherapy in breast cancer patients to taxane chemotherapy cycles.
- Trial name
- Acupuncture (NCT03373032)
- Testing
- Stiper, Acupuncture, Exercise
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma
Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure
This is a prospective phase II clinical trial to evaluate the efficacy and safety of apatinib and camrelizumab in recurrent or metastatic nasopharyngeal carcinoma who failed at least the first-line treatment.
- Conditions
- Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Metastatic Nasopharyngeal Carcinoma, Chemotherapy Effect
- Trial name
- NCT04586088
- Testing
- Apatinib plus Camrelizumab
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Sun Yat-sen University
Chemotherapy Effect, Chemotherapeutic Toxicity
Lower Urinary Tract Symptoms After Intravesical Therapy
With this prospective, observational study, we would like to investigate the effect of instillation therapy using BCG or mitomycin C on short- and long-term irritative and obstructive lower urinary tract symptoms using validated…
- Conditions
- Chemotherapy Effect, Chemotherapeutic Toxicity, Lower Urinary Tract Symptoms, Overactive Bladder
- Trial name
- LUTSI (NCT05844059)
- Testing
- Validated questionnaires
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
HPEC, Ovarian Cancer
HIPEC in Ovarian Carcinoma Clinical Stage IIIC and IV During Interval Laparotomy
Ovarian cancer is the leading cause of gynecological cancer mortality, with no current screening method effective for early diagnosis, with 75% of advanced stage patients being detected.
- Conditions
- HPEC, Ovarian Cancer, Women's Health: Neoplasm of Ovary, Chemotherapy Effect
- Trial name
- NCT03275194
- Testing
- HIPEC
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Cancer, Chemotherapy Effect
Needs Assessment of Cancer Patients With Complementary and Alternative Medicines
The chronic cancer status, multidisciplinary and ambulatory care, as well as the cumbersome effects of the disease and treatments, lead patients to consider other options than those offered by traditional medicine, such as…
- Trial name
- MAC'EVAL (NCT03954509)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Breast Cancer, Chemotherapy Effect
Efficacy of Supplement Adjuvant Capecitabine in HR+/HER2- Breast Cancer Patients With High Risks
According to the latest data from the World Health Organization's International Agency for Research on Cancer (IARC) for 2020, breast cancer has been the most prevalent cancer with 2.26 million new cases.
- Trial name
- NCT05212454
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer, Predictive Cancer Model
KM3D Multicenter Cancer Consortium: Predicting Patient Response Using 3D Cell Culture Models
This study will assess the ability of the Known Medicine platform to predict the efficacy of certain cancer drug treatments and to validate that tumor organoid drug sensitivity is representative of patient treatment outcomes.
- Conditions
- Cancer, Predictive Cancer Model, Effects of Chemotherapy
- Trial name
- NCT05338073
- Testing
- Known 3Dx Test
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Known Medicine, Inc.
Colorectal Cancer, Liver Metastases
ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to compare in resectable colorectal cancer liver metastasis patients.The main question it aims to answer is whether the 3-year progression-free survival rate (PFS) of "watching and waiting" is…
- Conditions
- Colorectal Cancer, Liver Metastases, Circulating Tumor Cell, Chemotherapy Effect
- Trial name
- NCT05815082
- Testing
- Colorectal cancer resection combined with liver metastasis resection., FOLFOX chemotherapy regimen
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Locally Advanced Gastric Adenocarcinoma, Chemotherapy Effect
Study of Comparing of With and Without Sequential Therapy of S-1
The goal of this single arm clinical trial is to learn about sequential S-1 adjuvant therapy in patient wich locally advanced gastric cancer.
- Trial name
- NCT05813015
- Testing
- Docetaxel, Tegafur-Gimeracil-Oteracil
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhejiang University
Breast Cancer, Peripheral Neuropathies
Topical Menthol Application in Chemotherapy-Related Peripheral Neuropathy in Patients With Breast Cancer
Peripheral neuropathy resulting from chemotherapy is a problem that concerns not only the individual but also their relatives and all healthcare personnel responsible for care.
- Conditions
- Breast Cancer, Peripheral Neuropathies, Chemotherapy Effect
- Trial name
- NCT05429814
- Testing
- Menthol Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Esophageal Squamous Cell Carcinoma, Chemotherapy Effect
Comparison of Chemoradiotherapy and Chemoradiotherapy Combined With Consolidation Chemotherapy for ESCC
This study is a phase III, multicenter, prospective randomized controlled clinical study comparing the efficacy of non-surgical esophageal squamous cell carcinoma with radical chemoradiotherapy and radical chemoradiotherapy…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemotherapy Effect, Side Effect of Drug
- Trial name
- NCT05775419
- Testing
- Consolidation chemotherapy (4 courses), Concurrent chemotherapy (2 courses)
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Locally Advanced Breast Cancer, Chemotherapy Effect
Neoadjuvant Inetetamab Combined With Pertuzumab and Paclitaxel/Carboplatin for Breast Cancer
Inetetamab (Cipterbin) is a newly marketed anti-HER2 monoclonal antibody with amino acid modified Fc region and enhanced antibody-dependent cellular cytotoxicity (ADCC) effect.
- Trial name
- NCT05749016
- Testing
- inetetamab with pertuzumab and paclitaxel/carboplatin (TCbIP) regimen
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer, Chemotherapy Effect
Chidamide in Combination With Vincristine Metronomic Chemotherapy for Advanced Triple-negative Breast Cancer
The mechanism of action of cidabenamide and the advantages of vincristine metronomic chemotherapy make it possible to combine the two drugs.
- Trial name
- NCT05747313
- Testing
- Chidamide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Metastatic Nasopharyngeal Carcinoma, Chemotherapy Effect
Efficacy and Safety of Sintilimab Plus Bevacizumab in Metastatic Nasopharyngeal Carcinoma After Failure of Platinum-based Chemotherapy: An Open-label Phase II Study
To evaluate the efficacy and safety of PD-1 immune checkpoint inhibitor combined with bevacizumab in the treatment of metastatic nasopharyngeal carcinoma after failure of platinum-based chemotherapy.
- Trial name
- NCT04872582
- Testing
- PD-1 Immune Checkpoint Inhibitor Combined With Bevacizumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- XIANG YANQUN
Gynecologic Cancer, Chemotherapy Effect
Effect on Adaptation to Cancer of Mobile Application Developed for Gynecological Cancer Patients
Getting a cancer diagnosis, the difficult treatments applied and the side effects that occur completely affect the life of the patient, shaking his future plans and adaptation mechanisms.
- Conditions
- Gynecologic Cancer, Chemotherapy Effect, Mobile Application, Physiological Adaptation
- Trial name
- NCT05131490
- Testing
- A mobile application intervention developed for gynecological cancer patients receiving chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Pamukkale University
Breast Cancer, Lymphoma, Large B-Cell, Diffuse
Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines
As the cancer-related prognosis improves thanks to recent advances in cancer-targeted therapies, the prognostic burden of chemotherapy-related complications - including cardiotoxicity - is increasingly recognised.
- Conditions
- Breast Cancer, Lymphoma, Large B-Cell, Diffuse, Cardiotoxicity, Left Ventricular Dysfunction
- Trial name
- CONTROL (NCT05728632)
- Testing
- Nebivolol
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Giulio Stefanini
Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma
Toripalimab and Gemcitabine in Recurrent or Metastatic Nasopharyngeal Carcinoma.
This is an open-label, single center, pilot trial to evaluate the safety and efficacy of toripalimab and gemcitabine in patients with recurrent or metastatic nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Metastatic Nasopharyngeal Carcinoma, Chemotherapy Effect
- Trial name
- NCT04405622
- Testing
- Toripalimab plus gemcitabine
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sun Yat-sen University
Side Effect of Chemotherapy
The Effect of Virtual Reality on Psychological Parameters in Patients Receiving Chemotherapy
It has been determined that after mastectomy, women have psychological problems such as deterioration of body image, fear of losing their feminine characteristics and sexual dysfunction.
- Trial name
- NCT05475509
- Testing
- Virtually reality
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University