Clinical trials: Effects of Heat
Glioma
Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
RATIONALE: heat shock protein gp96-peptide complex made from a person's tumor cells may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT02122822
- Testing
- gp96
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Amputation Stumps, Amputees
Moisture Management Liner Effectiveness Study
The comfort and fit of the residual limb within a prosthetic socket are of primary concern for many amputees. The residual limb is typically covered by non-breathable and non- thermally conductive materials that can create a warm…
- Conditions
- Amputation Stumps, Amputees, Amputation, Lower Limb Deformities, Congenital
- Trial name
- NCT04427007
- Testing
- Moisture Management Liner, Control Liner
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Dry Eye Symptom, Eye Fatigue
Effects and Safety of Steam Eye Mask With Acupoints Stimulation
To evaluate the effects and safety of the steam eye mask with acupoints stimulation by the moist heat of approximately 40 degree C for 20 minutes and massage acupoints on eyebrows for eye fatigue, dry eye symptoms and…
- Trial name
- NCT04584216
- Testing
- Steam Eye Mask with acupoints stimulation, Steam Eye Mask
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kao (Taiwan) Corporation
Ovarian Cancer
A Phase 1 Trial of Perfusion Induced Systemic Hyperthermia (PISH) Over Multiple Cycles for Terminal Ovarian Cancer
To confirm the safety of 6 cycles of Perfusion Induced Systemic Hyperthermia (PISH) provided every 28 days in 3rd line ovarian cancer patients.
- Trial name
- PISH-2 (NCT02093871)
- Testing
- ThermalCore Hyperthermia System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ThermalCore Inc
Alzheimer's Disease
A Study to Evaluate the Effect of Heat Application on the Delivery Profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
A study to assess the effect of heat application on the delivery profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
- Trial name
- NCT03438604
- Testing
- Donepezil TDS
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Solid Tumors, Non-small Cell Lung Carcinoma
A Study of DS-2248 in Participants With Advanced Solid Tumors
This phase 1 clinical trial is intended to understand the safety and tolerability of a new anticancer drug in subjects with advanced solid tumors.
- Trial name
- NCT01288430
- Testing
- DS-2248
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Daiichi Sankyo
Metastatic Solid Tumors, Stage 4 Cancer
The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.
This is a sequential, dose-escalation, non-randomized, prospective, early feasibility trial. The goal of this clinical trial is to gather information on the safety and the recommended dose of the Sarah Nanotechnology System.
- Trial name
- NCT07224464
- Testing
- The Sarah Nanotechnology System - intended to deliver thermal energy to malignant cells for the purpose of thermal destruction of these cells in patients with advanced metastatic solid tumors.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New Phase Ltd.
Non-Proliferative Diabetic Retinopathy
Clinical Study on the Efficacy and Safety of TNTL in the Treatment of Non-proliferative Diabetic Retinopathy
The goal of this clinical trial is to learn if drug TNTL works to treat non-proliferative diabetic retinopathy in adults. It will also learn about the safety of drug TNTL. The main questions it aims to answer are: 1.
- Trial name
- TNTL (NCT06817265)
- Testing
- TNTL, TNTL simulation preparation
- Where
- 30 sites in China
- Volunteers
- 360 people
- Sponsor
- Beletalent (Zhuhai) Pharmaceutical Co., Ltd
Anxiety Disorders, Alcohol Use Disorder
Treating Stress and Anxiety in Individuals With Alcohol Use Disorder (AUD)
CT fibers are found in the skin of most mammals and project to the insular cortex. Stimulation of CT fibers by light touch causes a release of oxytocin and is associated with feelings of comfort and wellbeing.
- Conditions
- Anxiety Disorders, Alcohol Use Disorder, Stress, Psychological
- Trial name
- NCT06224127
- Testing
- active heat, Active c tactile fiber stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Soovu Labs Inc.
Efficacy and Safety
A Phase IV Study of Huazhi Rougan Granule in the Treatment of Non-alcoholic Simple Fatty Liver
An open Label, Single-arm, Multicenter phase IV study; There was a 2-week screening period and a 12-week / 24-week treatment period
- Trial name
- NCT06202456
- Testing
- Huazhi Rougan granule
- Where
- China
- Volunteers
- 2,007 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Breast Neoplasms
Immunostimulating Interstitial Laser Thermotherapy in Breast Cancer
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT03039127
- Testing
- Immunostimulating Interstitial Laser Thermotherapy
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Clinical Laserthermia Systems AB
Neoplasms Pancreatic
Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT02973217
- Testing
- Immunostimulating Interstitial Laser Thermotherapy
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Clinical Laserthermia Systems AB
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Liver Cancer
GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Liver Cancer
This trial is to further study the safety and effectiveness of autologous gp96 treatment of liver cancer on the basis of preliminary work
- Trial name
- NCT04206254
- Testing
- gp96
- Volunteers
- 80 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Sexual Dysfunction, Physiological
Effect Of Menstrual Cycle On Vaginal Blood Flow In Pre-Menopausal Healthy Women.
The Pfizer developed Heat Wash-Out (HWO) system is a software controlled electromechanical system designed to measure vaginal wall blood flow. A small vaginal probe is attached to a control unit. Output data is collected on a PC.
- Trial name
- HWO VBF (NCT00443027)
- Testing
- Vaginal Heat Wash-Out Device
- Where
- 2 sites in Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Effects of Heat, Tolerability
Evaluation of Experimental Heat Patch
A disposable, air-activated, adhesive backed heat patch is being developed to provide temporary relief from minor muscular ache and joint pains associated with overexertion strains and sprains as well as minor pain associated…
- Conditions
- Effects of Heat, Tolerability, Adhesiveness, Dermal Irritation
- Trial name
- NCT01841788
- Testing
- Thermal Adhesion Patch, Marketed Thermal Adhesion Patch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Glioma of Brain
A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
This trial is to further study the safety and effectiveness of autologous gp96 treatment of glioblastoma on the basis of preliminary work.
- Trial name
- NCT03650257
- Testing
- gp96, Temozolomide, radiotherapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Plaque Psoriasis
Efficacy and Safety of Jiuweihuaban Pill for Treating Plaque Psoriasis
This study will evaluate the efficacy and safety of Jiuweihuaban Pill in the treatment of moderate to severe plaque psoriasis(syndrome of blood-heat ).
- Trial name
- NCT06058546
- Testing
- low dose Jiuweihuaban Pill, high dose Jiuweihuaban Pill
- Where
- 12 sites in China
- Volunteers
- 180 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Elastosis
PEAK PlasmaBlade™ vs. Traditional Electrosurgery in Abdominoplasty
The objective of this clinical study is to evaluate healing of incisions made with the PEAK PlasmaBlade 4.0 compared to scalpel and traditional electrosurgery (Bovie); to monitor and record key post-operative metrics following…
- Trial name
- PRECISE (NCT00943150)
- Testing
- PEAK PlasmaBlade, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Surgical Technologies
Eyelid Diseases
Clinical Safety Study on an Eyelid Warming Device to Evaluate the Eyelid and Cornea Temperature in Healthy Volunteers
The eyelid warming device is designed to relieve the symptoms of dysfunction of the glands in the eyelids. Prospective, non comparative, open, monocentre study.
- Trial name
- NCT01086943
- Testing
- LT2420
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea