Clinical trials: Effects of High Altitude
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Right Ventricular Function in Lowlanders
Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude
- Trial name
- NCT02730156
- Testing
- Altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema
The primary objective is to evaluate the efficacy of continuous positive pressure on resolution of high-altitude pulmonary edema vs high flow oxygen.
- Trial name
- NCT04186598
- Testing
- CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CommonSpirit Health
Exercise-induced Bronchoconstriction (EIB)
Hypoxic Environment on EIB and Performance in Race Walkers
Title: Diagnosis and Impact of Exercise-Induced Bronchoconstriction (EIB) in Athletes During Altitude Training Study Description: We invite you to participate in a research study examining Exercise-Induced Bronchoconstriction…
- Trial name
- EIB-H (NCT07466849)
- Testing
- High-Altitude Training & Hypoxic Environment Exposure
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Altitude Hypoxia, Neonatal Encephalopathy
Neonatal Electrical Activity at Different Altitude Levels
In this study, the objective is to compare neonatal cerebral electrical activity within 3 days after birth across different altitude areas using amplitude-integrated electroencephalography (aEEG), and establish reference value…
- Trial name
- NCT05966714
- Testing
- aEEG
- Where
- 2 sites in China
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Adult
Effects of RIC on Cognitive Function and Blood Oxygen Levels in Unacclimatized Adult at High Altitude
Several studies have shown cognitive impairment such as memory, perception and learning skill during ascent to high altitudes. However, few studies have directly investigated the effect of high altitudes exposure on attention-a…
- Trial name
- NCT03728114
- Testing
- RIC
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Acute Mountain Sickness
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour…
- Trial name
- NCT05023941
- Testing
- Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days)
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Ji Xunming,MD,PhD
Hypobaric Hypoxia, Metabolomics
Oxidative Stress in Hypobaric Hypoxia
The trial investigates changes in metabolism during high altitude expedition up to 6865m. A mass-spectrometry based platform is used to detect different oxidative stress related metabolites.
- Conditions
- Hypobaric Hypoxia, Metabolomics, Oxidative Stress, Acute Mountain Sickness
- Trial name
- NCT01436383
- Testing
- Hypoxic exposure
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypobaric Hypoxia
Pharmacological Countermeasures for High Altitude
The aim of this randomized, double-blind study is to determine whether erythropoietin (Procrit) and acetazolamide: 1) mitigates altitude-induced decrements in performance at moderate altitude (3,000 m) and 2) mitigates…
- Trial name
- NCT05300477
- Testing
- Acetazolamide, Erythropoietin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06072417
- Testing
- Assessment without intervention at High altitude, Relocation to sea level for 2 days
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Sleep Apnea
Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary…
- Trial name
- NCT01621061
- Where
- Kyrgyzstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
Altitude Sickness Prevention and Efficacy of Comparative Treatments
This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude.
- Trial name
- ASPECT (NCT02604173)
- Testing
- Budesonide, Acetazolamide
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypoxia, Altitude, Cold Exposure
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the…
- Conditions
- Hypoxia, Altitude, Cold Exposure, Heat Exposure
- Trial name
- NCT06159374
- Testing
- exercise and environmental conditions
- Where
- Poland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland