Clinical trials: Efficacy
Immunogenicity, Safety
mRNA Booster Vaccine(SW-BIC-213) Compared With Pfizer andSinopharm Against Emerging VOCs
Primary#Objectives #Immunogenicity:To demonstrate the non-inferiority of binding antibody response in terms of geometric mean titers (GMT) of mRNA vaccine compare with mRNA COVID-19 vaccine(Pfizer) 14 days post dose.
- Conditions
- Immunogenicity, Safety, Efficacy
- Trial name
- NCT05686161
- Testing
- SW-BIC-213;SARS-Cov-2., Sinopharm (BIBP);SARS-Cov-2., Pfizer(BNT162b2);SARS-Cov-2.
- Where
- Laos
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Stemirna Therapeutics
Obesity, Behavior, Health
Coached or Non-Coached Weight Loss Intervention
To evaluate the effect of one-on-one coaching in the Noom Healthy Weight Program, a digital behavior change, weight loss intervention, compared to the same program with no coaching, as well as influential factors.
- Conditions
- Obesity, Behavior, Health, Behavior, Eating, Weight Loss
- Trial name
- NCT04645108
- Testing
- Noom Healthy Weight; mobile behavior change program for weight loss with 1:1 coaching, Noom Healthy Weight; mobile behavior change program for weight loss
- Where
- United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Noom Inc.
Efficacy of a 21-Day Wear Period for the Cascade CGM
Glucomen Day Cascade CGM System 21-Day Wear Study
Assessment of 21-day CGM wear period
- Trial name
- GLUCODAY21 (NCT05460260)
- Testing
- Cascade CGM
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 10 people
- Sponsor
- WaveForm Technologies Inc.
Efficacy
TAB008 Compared to Avastin® in Patients With EGFR Wild-type Non-squamous Non-small Cell Lung Cancer
In this randomized, double-blind, multicenter, phase III similarity study, treatment naive, EGFR wild-type, locally advanced, metastatic, or recurrent non-squamous, non-small cell, lung cancer (ns-NSCLC) patients were enrolled…
- Trial name
- NCT05427305
- Testing
- TAB008, Bevacizumab
- Where
- China
- Volunteers
- 549 people
- Sponsor
- BioDlink Biopharm Co., Ltd.
Children Whose Mothers Received 17P and Those Who Received Vehicle in the 17P Efficacy Trial
A Prospective, Noninterventional Follow-Up Study of Children Aged 23 to 25 Months, Born to Mothers Who Received Hydroxyprogesterone Caproate Injection, 250 mg/mL, or Vehicle for Prevention of Preterm Birth
In the continuing efforts to understand the benefits and risks of in utero exposure to 17P this study is designed to evaluate differences in developmental outcomes of children, aged 23 to 25 months, born to mothers who…
- Trial name
- NCT01146990
- Testing
- ASQ-3, Bayley III, Neurologic exam
- Where
- 40 sites in United States, Canada and 5 more
- Volunteers
- 245 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Efficacy, Safety
A Trial Investigating the Effect of 4 Weeks Dosing of XEN-D0501 on Blood Glucose Reduction in Patients With Diabetes
This is a randomised, double-blind, placebo-controlled, parallel-group trial investigating the effect of 4 weeks bi-daily dosing of XEN-D0501 on blood glucose reduction as add-on to metformin in patients with diabetes mellitus…
- Conditions
- Efficacy, Safety, Pharmacokinetics, Diabetes Mellitus, Type 2
- Trial name
- NCT05353686
- Testing
- XEN-D0501
- Where
- 10 sites in Lithuania
- Volunteers
- 54 people
- Sponsor
- Pila Pharma
Motivation, Self Efficacy
Motivational Evaluation and Intervention With Co-Adapt Application for Healthy Ageing
The aim of this study is to identify effective methodologies to help people to improve their awareness of change, motivation, self-confidence and self-efficacy, compliance in behavioral change and psychological well-being.
- Trial name
- NCT05116553
- Testing
- SDT, APP + CA
- Where
- Italy
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Idego srl
Prevention of COVID-19, Safety and Efficacy
A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19
A randomized, double-blind, placebo-controlled international multicenter clinical trial design will be adopted. A total of 29,000 subjects aged 18 years and above are planned to be recruited, including 750 subjects aged 18-59…
- Trial name
- NCT04646590
- Testing
- Recombinant new coronavirus vaccine (CHO cell) group
- Where
- 18 sites in China, Ecuador and 3 more
- Volunteers
- 28,904 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Safety and Efficacy
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals
In summary, all evidence points in the direction that amino acid supplementation is justified for augmenting desired fat loss associated with physical exercise as an obesity therapy.
- Trial name
- NCT04785170
- Testing
- Amino Acid
- Where
- India
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Dose Escalation, Safety
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors
The purpose of this study is to determine the maximum dose of LDE225 and BKM120 that can be safely given together to patients and/or the dose that will be used in future studies.
- Conditions
- Dose Escalation, Safety, Preliminary Efficacy, Advanced Solid Tumors
- Trial name
- NCT01576666
- Testing
- LDE225, BKM120
- Where
- 23 sites in United States, Australia and 6 more
- Volunteers
- 120 people
- Sponsor
- Novartis Pharmaceuticals
To Determine Safety, Tolerability and Efficacy of ONCOS-102 in Combination With Chemotherapy
A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma
The trial is an open-label, parallel group, multicentre trial that will recruit a total of 30 patients with malignant pleural mesothelioma.
- Trial name
- NCT02879669
- Testing
- ONCOS-102, Pemetrexed/cisplatin (carboplatin), Cyclophosphamide
- Where
- 7 sites in France, Spain
- Volunteers
- 31 people
- Sponsor
- Targovax Oy
Moderate to Severe Convexity of Submental Fat, Safety
Safety Study of ATX-101 (Deoxycholic Acid) in Subjects With Mild or Extreme Fullness of Submental Fat
The objectives of this study are to explore the safety and efficacy of subcutaneous injections of Deoxycholic Acid relative to placebo, in the submental area in patients with mild or extreme fullness of the submental fat and…
- Conditions
- Moderate to Severe Convexity of Submental Fat, Safety, Efficacy
- Trial name
- NCT02035267
- Testing
- Deoxycholic Acid
- Where
- 8 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Moderate to Severe Convexity of Submental Fat, Safety
Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age
The objectives of this study are to explore the safety and efficacy of subcutaneous injections of Deoxycholic Acid relative to placebo, in the submental area of participants who are 65 to 75 years old.
- Conditions
- Moderate to Severe Convexity of Submental Fat, Safety, Efficacy
- Trial name
- NCT02123134
- Testing
- ATX-101
- Where
- 6 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Evaluate the Efficacy and Safety of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
Phase III Study to Evaluate the Efficacy and Safety of HOB-048 CR Tab. in Comparison With HOB-048 Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
A randomized, double-blind, multicenter, active-controlled phase III study to evaluate the efficacy and safety of Levotuss CR tab. in comparison with Levotuss syrup in patients with cough due to acute or chronic bronchitis
- Trial name
- NCT03489837
- Testing
- Levotuss
- Where
- South Korea
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharm
Overweight and Obesity, Weight Loss
BEFORE Study, Efficacy of Refigura
The BEFORE study ((B) EFficacy Of REfigura) is designed to demonstrate the efficacy of REFIGURA®. It is a double-blind, randomized, monocentric study.
- Conditions
- Overweight and Obesity, Weight Loss, Efficacy, Self
- Trial name
- NCT03557424
- Testing
- Polyglucosamine Glucomannan normal dose (Verum), Polyglucosamine Glucomannan high dose (Verum)
- Where
- Germany
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Heilpflanzenwohl AG
Asthma, Efficacy
A Multiple Dosing (14 Days) Study to Assess Efficacy and Safety of Three Dose Levels of AZD7594, Given Once Daily by Inhalation, in Patients With Mild to Moderate Asthma
This study will be a randomised, double-blind, multiple dose (14 days), placebo-controlled, multi-center study to assess efficacy and safety of three dose levels of AZD7594, given once daily by inhalation, in patients with mild…
- Conditions
- Asthma, Efficacy, Safety
- Trial name
- NCT02479412
- Testing
- 800 μg AZD7594 once daily, 250 µg AZD7594 once daily, 58 µg AZD7594 once daily
- Where
- 10 sites in Bulgaria, Germany
- Volunteers
- 54 people
- Sponsor
- AstraZeneca
Drug Safety, Normal Drug Tolerance
Remegal Different Doses in Patients With Refractory Partial Seizures
The purpose of this study is to determine weather different doses of Remegal are effective,safety and tolerant in Additional Therapy for Patients With Refractory Partial Seizures and pharmacokinetics definition
- Conditions
- Drug Safety, Normal Drug Tolerance, Self Efficacy
- Trial name
- NCT01179854
- Testing
- Remegal
- Where
- 4 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Valexfarm
Dental Anesthesia Efficacy
Safety and Effectiveness of Kovacaine Nasal Spray for Dental Anesthesia
The purpose of this study was to determine the safety and efficacy of Kovacaine Mist (3% tetracaine HCl with 0.05% oxymetazoline HCl) for anesthesia of the maxillary teeth for dental procedures.
- Trial name
- NCT01302483
- Testing
- 3% tetracaine HCL with 0.05% oxymetazoline HCL, Lidocaine Injection
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Efficacy and Safety of Mivacurium Chloride for Pediatric Patients
A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients
To evaluate the effect and safety of mivacurium chloride in pediatric patients.
- Trial name
- NCT02117401
- Testing
- mivacurium chloride, midazolam, ketamine
- Volunteers
- 1,152 people
- Sponsor
- Jiangsu Nhwa Pharmaceutical Co., Ltd.
Metastatic Castrate-Resistant Prostate Cancer (mCRPC),, Efficacy,
Investigating Safety, Tolerability and Efficacy of AZD5363 in Prostate Cancer.
To investigate the safety, tolerability and anti-tumour activity of AZD5363, as monotherapy, in patients with metastatic Castrate-Resistant Prostate Cancer.
- Conditions
- Metastatic Castrate-Resistant Prostate Cancer (mCRPC),, Efficacy,, Safety and Tolerability,, Pharmacokinetics,
- Trial name
- PYRUS (NCT01692262)
- Testing
- Intermittent dosing of AZD5363
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 59 people
- Sponsor
- AstraZeneca