Clinical trials: Ejection Fraction
Mitral Valve Stenosis With Incompetence or Regurgitation
The Effects of Levosimendan During Mitral Valve Surgery
The effects of levosimendan on renal function in patients with low ejection fraction undergoing mitral valve surgery will be investigated in a prospective, double-blinded, randomized clinical trial using serum creatinine…
- Trial name
- NCT01969071
- Testing
- Levosimendan, Dobutamine
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Sudden Cardiac Arrest, Ventricular Arrythmia
Improve Sudden Cardiac Arrest Study
The purpose of this study is to demonstrate that primary prevention patients with one or more additional risk factors (1.5 prevention criteria: syncope/pre-syncope, non-sustained ventricular tachycardia (NSVT), frequent…
- Trial name
- NCT02099721
- Testing
- ICD or CRT-D Device
- Where
- 93 sites in Argentina, Belarus and 14 more
- Volunteers
- 4,222 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Remodeling, Myocardial Dysfunction
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
Sacubitril-valsartan, an Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI), currently marketed for the management of heart failure, has been shown to reduce cardiovascular morbidity and mortality in stage C heart failure…
- Conditions
- Atrial Remodeling, Myocardial Dysfunction, Left Ventricular Remodeling, Left Ventricular Diastolic Dysfunction
- Trial name
- PARABLE (NCT04687111)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Mark Ledwidge
Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension, Right Heart Failure Due to Left Heart Failure
- Trial name
- HALT-RHF (NCT06299436)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Permanent Atrial Fibrillation, Preserved Ejection Fraction
Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial
The goal of this clinical trial is to learn whether left bundle branch area pacing, a technique designed to activate the heart's natural electrical conduction system, is better than conventional right ventricular pacing in adults…
- Trial name
- BEAT (NCT07759700)
- Testing
- LBBA pacing, Conventional pacing
- Where
- France
- Volunteers
- 642 people
- Sponsor
- Poitiers University Hospital
Preeclampsia, Heart Failure Preserved Ejection Fraction
Exercise Testing After Preeclampsia
Though cardiovascular disease (CVD) is the leading cause of mortality in women, traditional epidemiology in this area has focused on later life, when cardiometabolic risk has already exacted a cumulative toll on the vascular…
- Conditions
- Preeclampsia, Heart Failure Preserved Ejection Fraction, Hypertension
- Trial name
- NCT06741436
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure With Reduced Ejection Fraction, Mitral Regurgitation
The CardioClip Study
The CardioClip study is exploring the use of a wireless sensor to monitor pressure in the pulmonary artery. This sensor is inserted much like the mTEER procedure, a non-surgical method through a vein in the groin.
- Trial name
- CardioClip (NCT06241430)
- Testing
- CardioMEMS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Heart Failure With Preserved Ejection Fraction (HFPEF), Renal Dysfunction
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Renal Dysfunction, Stage B Heart Failure
- Trial name
- WE-CARE-HF-CMR (NCT07185100)
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- German Heart Institute
Heart Failure With Preserved Ejection Fraction, Remote Monitoring in Heart Failure
Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF
The goal of this clinical trial (MAGIC-HF) is to understand whether daily remote monitoring of pulmonary artery pressure using the CardioMEMS™ device and body water levels using a smart scale can improve the management of…
- Trial name
- MAGIC-HF (NCT06977477)
- Testing
- Remote Monitoring for Congestion Management in HFpEF Patients
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Efficacy and Safety of an LVEF-Guided Mavacamten Dose Up-Titration Strategy in Chinese Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy
This study aims to evaluate whether, under a treatment strategy primarily guided by left ventricular ejection fraction (LVEF), dose up-titration in adult patients with symptomatic obstructive hypertrophic cardiomyopathy who have…
- Trial name
- NCT07807384
- Testing
- Mavacamten
- Volunteers
- 115 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
HFpEF - Heart Failure With Preserved Ejection Fraction
The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)
This study will evaluate the effect of 12 weeks of treatment with tamibarotene compared with placebo on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with heart failure with preserved ejection fraction…
- Trial name
- RELIEF (NCT07855692)
- Testing
- Tamibarotene
- Where
- 4 sites in Japan
- Volunteers
- 90 people
- Sponsor
- Nagoya University
Obesity
Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity
This study will look at how the participants daily life is affected by their heart failure. The study will also look at the change in participants body weight from the start to the end of the study.
- Trial name
- STEP-HFpEF (NCT04788511)
- Testing
- Semaglutide
- Where
- 146 sites in United States, Argentina and 11 more
- Volunteers
- 529 people
- Sponsor
- Novo Nordisk A/S
Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
- Trial name
- AMEND (NCT05887271)
- Testing
- Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Leicester
Heart Failure With Preserved Ejection Fraction, Obesity
Adipose Tissue Inflammation in HFpEF
To evaluate the role of adipose tissue inflammation in patients with heart failure with preserved ejection fraction (HFpEF). Patients undergoing coronary artery bypass grafting with HFpEF and without heart failure will be…
- Trial name
- SLIM-HFpEF (NCT04886713)
- Testing
- Adipose and myocardial tissue sampling, Cardiac magnetic resonance imaging, Cardiopulmonary exercise testing
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart Center Leipzig - University Hospital
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Diastolic Heart Failure, Diastolic Dysfunction
CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)
The study objective is to demonstrate safety and feasibility of the CORolla® TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with…
- Trial name
- NCT02499601
- Testing
- CORolla™ TAA device
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Heart Failure With Reduced Ejection Fraction (HFrEF), Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
This retrospective study will take advantage of an existing EU-funded dataset, the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF), which was designed to identify biomarkers related to the response to…
- Trial name
- NCT07470554
- Where
- Italy
- Volunteers
- 4,254 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Echocardiography, Medicine, Emergency
Concordance AUTOFEVG
Clinical ultrasound has become essential in emergency medicine. The guidelines are to use of echocardiography in specific contexts: dyspnea, hypotension or chest pain.
- Conditions
- Echocardiography, Medicine, Emergency, Technology Assessment, Biomedical, Heart Diseases
- Trial name
- CONCORDANCEVEF (NCT04641169)
- Testing
- echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart; Disease, Mitral(Valve)
Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department
Left ventricular ejection fraction (LVEF) is a parameter that should be evaluated rapidly to the patients, admitted to the emergency department with shortness of breath.
- Trial name
- NCT02657824
- Testing
- dyspneic patients
- Volunteers
- 113 people
- Sponsor
- Bozyaka Training and Research Hospital
Heart Failure
Alleviate-HF-2 Study
Patients with heart failure and preserved left ventricular ejection fraction (HFpEF, EF ≥ 50%) or mid-range left ventricular ejection fraction (HFmrEF, 40% < EF < 50%) with mild to moderate functional limitation will be evaluated…
- Trial name
- NCT04838353
- Testing
- ALV1 System
- Where
- 5 sites in Australia, Canada and 2 more
- Volunteers
- 13 people
- Sponsor
- Alleviant Medical, Inc.
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