Clinical trials: Ejection Fraction
Heart Failure With Reduced Ejection Fraction
Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction
Heart failure with reduced ejection fraction (HFrEF) is frequently associated with abnormalities in body composition, including reduced skeletal muscle mass and sarcopenia, which are independent predictors of reduced exercise…
- Trial name
- NCT07595809
- Testing
- Resistance Exercise, Dietary Intervention
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Heart Failure, Heart Failure With Reduced Ejection Fraction
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Obesity, Overweight
- Trial name
- SLEnDR (NCT05942287)
- Testing
- Diet intervention
- Where
- 2 sites in Jersey, United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Inflammation Biomarkers, Heart Failure
Descriptive Study of Circulating Gene or Protein Inflammatory Biomarkers and Bioimpedance Parameters in a Population of Patients Hospitalized for Decompensated Heart Failure With Preserved or Mildly Reduced Cardiac Function
The goal of this observational study is to determine whether changes in the inflammatory profile of heart failure patients can help identify those who may have a worse prognosis or who might benefit more from specific treatments.
- Trial name
- BIOFEVIP (NCT07320014)
- Testing
- Inflammatory biomarker sample collection
- Volunteers
- 112 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Heart Failure, Diastolic
CoQ10 and D-ribose in Patients With Diastolic Heart Failure
The purpose of this study is to compare the clinical benefits of CoQ10 and D-ribose taken by patients who have diastolic heart failure, or heart failure with preserved ejection fraction (HFpEF).
- Trial name
- NCT03133793
- Testing
- CoQ10, D-Ribose Oral Powder
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Diastolic Heart Failure, Heart Failure With Preserved Ejection Fraction
Role of Exercise in Diastolic Heart Failure
Diastolic heart failure is now being recognized as a key form of heart failure in older people. The focus of this research is to study ways to improve and maintain physical activity and functioning.
- Trial name
- NCT01047631
- Testing
- Functional circuit training and lifestyle counseling, Health education and independent walking
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
HFrEF - Heart Failure With Reduced Ejection Fraction
Vsling™ III: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
Prospective, multi-center, open-label clinical study of the feasibility and initial safety and performance of the Vsling™ in patients with heart failure (HF) with evidence of reduced left ventricular ejection fraction, associated…
- Trial name
- Vsling III (NCT06002386)
- Testing
- Vsling
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Cardiac Success
Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease
Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease
Assessment of Biomarkers in Patients with Decompensated Heart Failure and Underlying Coronary Artery Disease
- Trial name
- NCT03551756
- Testing
- Biomarker Assessment
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- CirQuest Labs, LLC
Heart Failure With Reduced Ejection Fraction
HFrEF Polypill in Sri Lanka RCT
The aim of this study is to evaluate, in adults with HFrEF in Sri Lanka, the effects of an HFrEF polypill implementation strategy on the composite rate of cardiovascular disease mortality and recurrent heart failure…
- Trial name
- NCT07569640
- Testing
- Usual Care, HFrEF Polypill
- Where
- 12 sites in Sri Lanka
- Volunteers
- 1,672 people
- Sponsor
- Washington University School of Medicine
Heart Failure With Preserved Ejection Fraction
Finerenone and Cardiac Remodeling in HFpEF
This prospective randomized study aims to evaluate the efficacy of Finerenone as add-on therapy to standard of care compared to standard of care alone in preventing heart failure worsening and preserving cardiac function assessed…
- Trial name
- NCT07830940
- Testing
- Finerenone, Standard of care for HFpEF Description:
- Volunteers
- 194 people
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction
Extended IASD Investigation: REDUCE LAP-HF IV
Multicenter, Prospective, Open Label, Single Arm, Clinical Trial. The primary objective of this clinical trial is to further evaluate the safety and clinical efficacy of the IASD System II in symptomatic heart failure patients…
- Trial name
- NCT04632160
- Testing
- IASD System II
- Sponsor
- Corvia Medical
Cardiac Disease
PROSPECTIVE EVALUATION OF HEARTFOCUS
The study's objective is to evaluate if exams, performed with the HeartFocus software by novices, are of sufficient quality to visually analyze the left ventricular size, the left ventricular function, the right ventricular size…
- Trial name
- HF-01 (NCT05874128)
- Testing
- Using HeartFocus software with AI guidance (Novices), Using HeartFocus software without AI-guidance
- Where
- 2 sites in United States, France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- DESKi
Ejection Fraction
Effect of Gemigliptin Versus Glimepiride on Cardiac Diastolic Function in Patients With Type 2 Diabetes
Among DPP-4 inhibitors, gemigliptin is a relatively recently developed drug, and many clinical studies have shown results that are equivalent to or superior to existing DPP-4 inhibitors such as sitagliptin.
- Trial name
- NCT05663736
- Testing
- Gemigliptin, Glimepiride
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Heart Failure With Preserved Ejection Fraction, Hypertension
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is a critical public health problem. Heart failure (HF) affects over 5 million adults in the United States (US), and is a major source of morbidity, mortality, and impaired…
- Trial name
- BLOCK HFpEF (NCT04434664)
- Testing
- Amlodipine Besylate, Metoprolol Succinate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Heart Failure With Preserved Ejection Fraction
Effort-Lung Ultra Sound
The E-LUS study is a prospective, non randomised, monocenter case-control study. The main objective is to evaluate the association of exercise lung ultrasound data acquired during a stress test on a bicycle ergometer with the…
- Trial name
- E-LUS (NCT04644692)
- Testing
- Lung ultrasound
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Diastolic
Optimized Management of Comorbidity in Heart Failure With Preserved Ejection Fraction in the Elderly (>60 Years)
Growing recognition of the importance of co-morbidities in Heart Failure with Preserved Ejection Fraction (HFPEF) has led to the realization that rather than being a distinct disease entity, HFPEF may represent a spectrum of…
- Trial name
- OPTIMIZE-HFPEF (NCT02425371)
- Testing
- Screening and treatment of comorbidities
- Where
- Sweden
- Volunteers
- 410 people
- Sponsor
- Göteborg University
Heart Failure
Assessing the Safety/Efficacy of Transdermal Testosterone in Female Patients With Symptomatic Heart Failure
Heart failure (HF) is a complex condition resulting from structural or functional heart diseases that impair the ability of the heart to fill with or pump out blood.
- Trial name
- CORDELIA (NCT00957034)
- Testing
- testosterone
- Where
- 16 sites in United States
- Volunteers
- 17 people
- Sponsor
- Warner Chilcott
HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction
Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a common condition among older adults. It is associated with frequent hospitalizations, impaired functional capacity, reduced quality of life, and high healthcare…
- Conditions
- HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction, Readmission Rates, Exercise Training
- Trial name
- EMPOWER-HFpEF (NCT07727096)
- Testing
- Exercise-Based Cardiac Rehabilitation, Guideline-Directed Medical Therapy
- Where
- Spain
- Volunteers
- 390 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure, Diabete Type 2
Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs
This clinical study aims to improve the diagnosis and treatment of cardiovascular diseases in Kazakhstan by Implementing Metabolic Correction with Glucagon-Like Peptide-1 (GLP-1).
- Conditions
- Heart Failure, Diabete Type 2, Arterial Hypertension
- Trial name
- ICDDTKZ26 (NCT07303556)
- Testing
- Tirzepatide (Mounjaro), dapagliflozin, empagliflozin, metformin
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Nazarbayev University
Heart Failure
The Role of Chronotropic Incompetence in Heart Failure With Normal Ejection Fraction (HFNEF)
What is heart failure with normal ejection fraction? The heart contracts (pumps) and relaxes with each heartbeat. In some people with heart failure, the heart contracts normally but there is reduced relaxation of the heart.
- Trial name
- NCT02354573
- Testing
- Ivabradine
- Where
- United Kingdom
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Oxford
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