Clinical trials: Ejection Fraction
Heart Failure, Heart Failure With Reduced Ejection Fraction
Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF)
Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF) is a pragmatic, cluster-randomized, three-arm intervention trial that will compare the effectiveness of two…
- Trial name
- BETTER CARE-HF (NCT05275920)
- Testing
- Best Practice Alert (BPA), In-Basket Message
- Where
- United States
- Volunteers
- 2,211 people
- Sponsor
- NYU Langone Health
Heart Failure With Preserved Ejection Fraction
Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction
The heart is a pump that must both fill and empty effectively to move blood; if it cannot move enough, heart failure may ensue. Approximately half of all adults living with heart failure have a form where the heart stiffens…
- Trial name
- NCT05582044
- Testing
- Lower-body Negative Pressure (-25 mmHg), Lower-body Negative Pressure (-15 mmHg), Lower-body Neutral Pressure (0 mmHg)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pacemaker, Diastolic Dysfunction
Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ejection Fraction
Recent exploratory studies suggest that pacemaker patients with diastolic dysfunction (DD) or heart failure with preserved ejection fraction (HFpEF) may benefit from a higher backup heart rate (HR) setting than the factory…
- Conditions
- Pacemaker, Diastolic Dysfunction, Diastolic Heart Failure
- Trial name
- myPACE (NCT04721314)
- Testing
- Adjustment of lower rate limit, Maintenance of lower rate limit
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Vermont
Heart Failure With Preserved Ejection Fraction
Dapagliflozin With or Without Spironolactone for HFpEF
Heart failure (HF) is a condition in which the heart does not contract ("pump") or relax well, leading to insufficient perfusion of vital organs.
- Trial name
- SOGALDI-PEF (NCT05676684)
- Testing
- Dapagliflozin, Spironolactone + Dapagliflozin
- Where
- 2 sites in Portugal
- Volunteers
- 108 people
- Sponsor
- Universidade do Porto
Heart Failure
Heart Failure With Normal Ejection Fraction (HFNEF) in Hemodialysed Patients: Beneficial Effect of Ivabradine
Heart failure with normal ejection fraction is often under diagnosed and certainly under treated in hemodialyzed patients. Because of the benefit of reducing heart rate, ivabradine, a pure heart-rate lowering agent without…
- Trial name
- NCT01373619
- Testing
- Ivabradine
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response
This study aims to investigate whether the investigators can improve heart function in patients with heart failure who have undergone cardiac resynchronization therapy, but have not had an improvement in their heart function at…
- Conditions
- Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
- Trial name
- NCT05884411
- Testing
- Left bundle branch area pacing, Cardiac MRI
- Where
- United States
- Sponsor
- VA Office of Research and Development
IHD, LV Dysfunction
Coronary Artery Bypass Grafts or Percutaneous Coronary Intervention for High Risk Patients
Most patients with Left Ventricular Systolic Dysfunction (LVSD) or heart failure (HF) have coronary artery disease (CAD) while some patients also have renal disease.
- Trial name
- NCT05534698
- Testing
- PCI, CABG
- Where
- Denmark
- Volunteers
- 1,550 people
- Sponsor
- Danish Study Group
Heart Failure With Preserved Ejection Fraction, Myocardial Fibrosis
Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction
Cardiac magnetic resonance imaging (MRI) measures of myocardial interstitial fibrosis (MIF) are elevated in heart failure with preserved ejection fraction (HFpEF) patients and associated with poor prognosis.
- Trial name
- NCT06536309
- Testing
- Sacubitril-valsartan, Valsartan
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation
Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation
A randomized, double-blinded, placebo-controlled study to evaluate the effect of spironolactone in addition to conventional treatment compared with placebo in patients with paroxysmal and persistent atrial fibrillation with…
- Trial name
- INSPIRE-AF (NCT02764619)
- Testing
- Spironolactone
- Where
- Denmark
- Volunteers
- 125 people
- Sponsor
- Svendborg Hospital
HFpEF, Heart Failure With Preserved Ejection Fraction
Heart Failure With Preserved Ejection Fraction and Its Cardiac MR Characteristics of Different Subtypes
Using cardiac magnetic resonance imaging technology, the ejection fraction of heart failure (HFpEF) and different subtypes of cardiac magnetic resonance characteristics, and combined with the clinical characteristics and…
- Trial name
- NCT06916611
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Heart Failure, Diastolic
External Body Pressure in Heart Failure With Preserved Ejection Fraction
The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and…
- Trial name
- NCT05764564
- Testing
- Positive or negative pressure
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal)
PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal), Persistent Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PREACTIVE (NCT07324772)
- Testing
- progressive resistance training, combined aerobic + resistance training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Coronary Artery Bypass Grafting, Left Ventricular Dysfonction
Preoperative Levosimendan in CABG Patients With Poor LV Function
The investigators want to test the hypothesis that an infusion of levosimendan started prior to CABG surgery can reduce incidence and severity of low cardiac output syndrome in patients with poor LV function (EF 40% or less).
- Trial name
- LICORN (NCT02184819)
- Testing
- levosimendan
- Where
- France
- Volunteers
- 335 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure With Reduced Ejection Fraction
Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure
The purpose of this study is to evaluate the effect of treatment with omecamtiv mecarbil compared with placebo on exercise capacity as determined by cardiopulmonary exercise testing following 20 weeks of treatment with omecamtiv…
- Trial name
- METEORIC-HF (NCT03759392)
- Testing
- Omecamtiv Mecarbil
- Where
- 81 sites in United States, Canada and 7 more
- Volunteers
- 276 people
- Sponsor
- Cytokinetics
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
MRI Scans
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
This study's main specific aims are; 1. To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion…
- Trial name
- NCT04600115
- Testing
- Adenosine, Regadenoson, O-15 labeled radioactive water
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Utah
Dietary Exposure
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes
Open, Single arm intervention, feasibility study
- Trial name
- ALLEVIATE (NCT04173117)
- Testing
- Low energy meal replacement plan (12 weeks)
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- University of Leicester
Heart Failure, Cardiac Resynchronisation Therapy
Effects of Endurance Training on Patients With Reduced Left Ventricular Ejection Fraction (LVEF) and Cardiac Resynchronisation Therapy Especially for Cardiac Arrhythmias
A severely reduced left ventricular ejection fraction is associated with increased mortality due to pump failure as well as to malignant ventricular arrhythmia.
- Conditions
- Heart Failure, Cardiac Resynchronisation Therapy, Sudden Cardiac Death
- Trial name
- NCT00472238
- Testing
- endurance training, exercise training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Heart Failure, Diastolic
Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04603404
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure With Reduced Ejection Fraction
Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event
To explore two modalities of treatment initiation (Pre-discharge, and Post-discharge) with LCZ696 in HFrEF patients following stabilization after an ADHF episode.
- Trial name
- TRANSITION (NCT02661217)
- Testing
- LCZ696
- Where
- 152 sites in Argentina, Belgium and 17 more
- Volunteers
- 1,002 people
- Sponsor
- Novartis Pharmaceuticals
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