Clinical trials: Ejection Fraction
Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction
A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
To evaluate the effect of CS reducer implantation in patients with HFPEF and CMD on myocardial ischemia, measured by stress myocardial perfusion using cardiovascular magnetic resonance (CMR)
- Trial name
- NCT07093528
- Testing
- Cardiovascular Magnetic Resonance (CMR)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Heart Failure With Reduced Ejection Fraction, Ketosis
Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction
This randomized controlled trial will evaluate the effect of a ketogenic diet and/or exogenous administration of ketone bodies vs conventional diet on the ejection fraction of patients with non-ischemic chronic heart failure…
- Trial name
- NCT04921293
- Testing
- Ketogenic diet, Exogenous ketones
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Heart Failure
Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction
This is a randomized double blinded controlled trial of 20-40 mg sodium nitrite tid in subjects with HFpEF. Primary outcomes are measures of physical function with non-invasive and invasive cardiopulmonary exercise testing, and…
- Trial name
- ONOH (NCT02918552)
- Testing
- sodium nitrite, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gladwin, Mark, MD
Heart Failure With Preserved Ejection Fraction, Hypomagnesemia
Intracellular Magnesium and Heart Failure
Low magnesium levels are surprisingly common in those with a heart condition known as HFpEF, where the heart pumps well but is too rigid to fill properly with blood.
- Trial name
- NCT06353750
- Testing
- Magnesium supplement
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Diastolic Heart Failure
Metoprolol XR in Heart Failure With Normal Ejection Fraction
In contrast to the treatment of HF with reduced EF, information to guide the pharmacological therapy of patients with HFNEF are lacking and there is no evidence based treatment for patients with HFNEF.
- Trial name
- HFNEF (NCT03882710)
- Testing
- Metoprolol XR
- Where
- India
- Volunteers
- 102 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure
Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)
This study will look at whether using a phone app called StudyU can help people with Heart Failure with Reduced Ejection Fraction (HFrEF) reach their recommended dose on their beta blocker.
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure, Heart Failure, Systolic, Heart Diseases
- Trial name
- N-of-1 App (NCT07252310)
- Testing
- beta blockers, StudyU Application
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Weill Medical College of Cornell University
Acute Heart Failure
Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure
Single center, prospective, randomized, non-blinded research study comparing intravenous vasodilator infusion vs. inotropic infusion in patients admitted to the hospital or in the emergency room at Montefiore Medical Center…
- Trial name
- PRIORITY-ADHF (NCT02767024)
- Testing
- Sodium nitroprusside, Dobutamine, Furosemide
- Where
- United States
- Sponsor
- Montefiore Medical Center
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
This was a multicenter, randomized (1:1; oral treprostinil to placebo), double-blind, placebo-controlled study in subjects with World Health Organization (WHO) Group 2 pulmonary hypertension (PH) associated with heart failure…
- Trial name
- NCT03037580
- Testing
- Oral treprostinil
- Where
- 82 sites in United States
- Volunteers
- 84 people
- Sponsor
- United Therapeutics
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction
The objective of CABA-HFPEF is to test whether catheter ablation (CA) for atrial fibrillation (AF) can prevent adverse cardiovascular outcomes in patients with heart failure with preserved (HFpEF) or mildly reduced ejection…
- Conditions
- Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
- Trial name
- CABA-HFPEF (NCT05508256)
- Testing
- CE-marked Catheter Ablation
- Where
- Germany
- Volunteers
- 1,548 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Heart Failure With Reduced Ejection Fraction
A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction
Researchers are looking for a better way to treat people who have chronic heart failure with reduced ejection fraction. Chronic heart failure with reduced ejection fraction (HFrEF) is a long-term condition that occurs when the…
- Trial name
- NCT06195930
- Testing
- Vericiguat (BAY1021189) 5 mg
- Where
- 35 sites in United States, Argentina and 5 more
- Volunteers
- 106 people
- Sponsor
- Bayer
Heart Failure With Normal Ejection Fraction
Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity
The main objective is to test the hypothesis that inorganic nitrate supplementation will: (1) Improve exercise efficiency and performance; (2) Enhance the systemic vasodilator reserve during exercise and specifically, the…
- Trial name
- NCT01919177
- Testing
- Nitrate rich beetroot juice, Nitrate depleted beetroot juice
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Heart Failure With Preserved Ejection Fraction (HFPEF), Chronic Heart Failure
Fecal Microbiota Transplantation for Elderly Patients With HFpEF: A Randomized Controlled Trial
This is a single-center, randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) in elderly patients with heart failure with preserved ejection…
- Trial name
- NCT07628777
- Testing
- Fecal Microbiota Transplantation (FMT) Capsules
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Air Force Medical University
Cardiac Disease
Kosmos Trio and Ejection Fraction Pivotal Study
This is a single-group, observational study which will involve obtaining two echo scans of recruited patients. All recruited patients will undergo echo scans by both novice users (nurses) and experts (echo sonographers).
- Trial name
- NCT06027164
- Testing
- Portable Ultrasound System
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- EchoNous Inc.
Heart Failure With Reduced Ejection Fraction
Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure
Heart Failure (HF) is a significant health concern, affecting around 1-2% of people in Western countries. The risk of developing HF during a lifetime is about 20%.
- Trial name
- KETO-CHF PET (NCT06398964)
- Testing
- 3-hydroxybutyrat
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Heart Failure
Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction
A randomized, double-blinded, placebo-controlled crossover study to assess effect of isosorbide mononitrate with dose up-titration on activity tolerance as assessed by (hip-worn, tri-axial) accelerometry.
- Trial name
- NEAT-HFpeF (NCT02053493)
- Testing
- Isosorbide Mononitrate
- Where
- 22 sites in United States
- Volunteers
- 110 people
- Sponsor
- Adrian Hernandez
Heart Failure With Preserved Ejection Fraction
Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction
This study is to evaluate whether 16 weeks of treatment with IMR-687 is a safe and effective treatment for patients with Heart Failure with Preserved Ejection Fraction (HFpEF).
- Trial name
- SP9In-HFpEF (NCT05312021)
- Testing
- IMR-687
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Heart Failure With Preserved Ejection Fraction (HFpEF)
DevElopMent of Clinical PATHwaYs to the Diagnosis of Heart Failure With Preserved Ejection Fraction
Prevalence of heart failure with preserved ejection fraction (HFpEF) continues to increase in the developed world, likely because of the increasing life expectancy and an increasing number of elderly patients.
- Trial name
- EMPATHY-HF (NCT05792059)
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure With Reduced Ejection Fraction
Ketones in Heart Failure With Reduced Ejection Fraction
The purpose of this study is to understand the effects of a ketone drink on exercise capacity and other cardiovascular parameters in patients with heart failure.
- Trial name
- HFrEF (NCT06195982)
- Testing
- ketone ester
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Heart Failure
Polypill Strategy for Heart Failure With Reduced Ejection Fraction
Heart failure with a reduced ejection fraction (HFrEF) represents a significant public health burden in the United States, with a growing prevalence particularly among African Americans and Hispanic Americans and individuals of…
- Trial name
- POLY-HF (NCT04633005)
- Testing
- Polypill, Control Rx
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Breast Tumors
Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer
The goal of this study is to determine if co-administration of metformin and doxorubicin in breast cancer patients receiving neoadjuvant or adjuvant therapy will reduce the number of patients who develop a significant change in…
- Trial name
- NCT02472353
- Testing
- Metformin, Doxorubicin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Avera McKennan Hospital & University Health Center
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