Clinical trials: Ejection Fraction
Cardiac Pacing, Right Ventricular Pacing
Optimize RV Follow-up Selective Site Pacing Clinical Trial
The purpose of the Optimize RV Follow-Up study is to determine the long-term effect of selective site pacing. Selective site pacing refers to which area of the right ventricle the lead is placed.
- Conditions
- Cardiac Pacing, Right Ventricular Pacing, Left Ventricular Ejection Fraction
- Trial name
- ORVFUP (NCT00949715)
- Testing
- Medtronic or Vitatron Dual-Chamber Pacemaker, Medtronic SelectSecure 3830 Lead
- Where
- 12 sites in United States, Israel and 1 more
- Volunteers
- 67 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Hyperkalaemia, Heart Failure with Reduced Ejection Fraction
Hyperkalaemia and Its Impact on Therapy with RAASi
Renin-angiotensin-aldosterone system inhibitors (RAASi) have transformed prognosis of patients with heart failure with reduced ejection fraction, diabetic nephropathy and chronic kidney disease.
- Conditions
- Hyperkalaemia, Heart Failure with Reduced Ejection Fraction, Left Ventricular Systolic Dysfunction
- Trial name
- REVIEW (NCT04249648)
- Where
- United Kingdom
- Volunteers
- 651 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Central Sleep Apnea, Heart Failure With Preserved Ejection Fraction
Quality of Sleep of Patients With Predominant Central Sleep Apnea Syndrome(SAS) Whose EF > 45% Treated by ASV
The main goal of this French multicenter observational cohort study is to prospectively collect data assessing the impact of the Adaptative Servo-Ventilation treatment on the quality of sleep of patients with central or combined…
- Trial name
- FACIL-VAA (NCT02835638)
- Testing
- Adaptative Servo Ventilation
- Where
- 28 sites in France
- Volunteers
- 520 people
- Sponsor
- Société Française de Recherche et de Médecine du Sommeil
Heart Failure, Electric Impedance
Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction
REDICAE trial was designed to evaluate the safety and tolerability of diuretics withdrawal in stable, euvolemic chronic outpatients with heart failure with reduced ejection fraction.
- Conditions
- Heart Failure, Electric Impedance, Dyspnea, Safety
- Trial name
- REDICAE (NCT05964738)
- Testing
- Diuretics withdrawal, Diuretics maintenance
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Heart Failure With Preserved Ejection Fraction
Surgical Resection of the Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fraction
We believe that blocking of the Greater Splanchnic Nerve (GSN) will stop Sympathetic Nervous System (SNS) activity from reaching the splanchnic vessels and result in a redistribution of blood volume back into the splanchnic…
- Trial name
- NCT03715543
- Testing
- Surgical Resection of the Greater Splanchnic Nerve
- Where
- 2 sites in Czechia, Poland
- Volunteers
- 8 people
- Sponsor
- Noblewell
Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
The aim of this open-label (OL) extension trial is to study the long-term safety and efficacy of macitentan in subjects with heart failure with preserved ejection fraction (HFpEF) and pulmonary vascular disease (PVD) beyond the…
- Trial name
- SERENADE OL (NCT03714815)
- Testing
- macitentan 10 mg
- Where
- 44 sites in United States, Argentina and 13 more
- Volunteers
- 91 people
- Sponsor
- Actelion
Heart Failure
Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania
Angiotensin-neprilysin inhibitors (ARNI) are beneficial in patients with heart failure with reduced ejection fraction. No study evaluating ARNI has been conducted in sub-Saharan Africa (except South Africa) yet, where heart…
- Trial name
- NCT06704633
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Tanzania
- Volunteers
- 298 people
- Sponsor
- Martin Rohacek
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of Sacubitril/Valsartan (Sac/Vals) compared to no initiation of the drug in patients with transthyretin cardiac amyloidosis…
- Trial name
- SAVA-TTR (NCT06712030)
- Testing
- Sacubitril / Valsartan
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Puerta de Hierro University Hospital
Non-obstructive Hypertrophic Cardiomyopathy
A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)
This is a multicenter, exploratory, randomized, double-blind study of the administration of mavacamten in 60 participants with symptomatic nHCM randomized to receive a 16-week course of mavacamten doses titrated to achieve 1 of 2…
- Trial name
- MAVERICK-HCM (NCT03442764)
- Testing
- mavacamten
- Where
- 32 sites in United States
- Volunteers
- 59 people
- Sponsor
- MyoKardia, Inc.
Heart Failure With Normal Ejection Fraction
The Heart Failure With Preserved Ejection Fraction (HFpEF) Pathophysiology Study.
The study addresses the hypothesis that a gradual build-up in arterial resistance and microvascular endothelial dysfunction due to common comorbidities such as hypertension and diabetes mellitus, on top of age related vascular…
- Trial name
- IDENTIFY-HF (NCT03186833)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Assessment of the RV Function in Patients With Heart Faliure
Right Ventricular Function in Heart Failure
Only a few studies evaluated the RV systolic function in the three categories of HF, regarding the importance of understanding changes in RV function on clinical presentation and outcome; it was essential to understand the…
- Trial name
- NCT03641599
- Testing
- echocardiography
- Volunteers
- 150 people
- Sponsor
- shaimaa Mostafa
Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction
Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study
The recent study is planned to investigate the impact of Ertugliflozin on total burden of ventricular arrhythmias. Further objectives will be number of therapeutic interventions of implanted devices, atrial fibrillation, heart…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy
- Trial name
- ERASE (NCT04600921)
- Testing
- Ertugliflozin 5 mg
- Where
- 8 sites in Austria
- Volunteers
- 55 people
- Sponsor
- Medical University of Graz
Heart Failure
Heart Failure With Mildly Reduced Ejection Fraction Registry
Heart failure (HF) affects about 1% of patients younger than 55 years, whereas the prevalence of HF increases > 10% in patients with at least 70 years of age.
- Trial name
- HARMER (NCT05603390)
- Where
- Germany
- Volunteers
- 2,200 people
- Sponsor
- Universitätsmedizin Mannheim
Heart Failure With Reduced Ejection Fraction
Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure
This study evaluate the dosage of bisoprolol plasma residual concentrations in chronic heart failure with mild to reduced ejection fraction adult patients by dose and renal function.
- Trial name
- PREVALENT (NCT03644446)
- Testing
- Bisoprolol plasma residual concentration dosage
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Cardiovascular Diseases, Heart Failure
Yôga and Breathing Techniques Training in Patients With Heart Failure and Preserved Ejection Fraction
Current therapies for heart failure (HF) bring together strategies to improve quality of life and exercise tolerance, as well as to reduce morbidity and mortality.
- Conditions
- Cardiovascular Diseases, Heart Failure, Heart Failure, Diastolic
- Trial name
- NCT03028168
- Testing
- Yôga, Breathing technique, Control group
- Where
- 2 sites in Brazil
- Volunteers
- 32 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure, Heart Failure With Preserved Ejection Fraction
Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure
This is a study of the DASH diet (Dietary Approaches to Stop Hypertension) in the exploration of effective strategies for Heart failure (HF) with preserved ejection fraction (HFPEF) prevention.
- Trial name
- DASHF (NCT04113291)
- Testing
- DASH Diet, Usual diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dilated Cardiomyopathy, Heart Failure
PUFAs and Left Ventricular Function in Heart Failure
The purpose of this study is to test the hypothesis that n-3 PUFAs improve left ventricular systolic function in patients with stable chronic HF secondary to nonischemic dilated cardiomyopathy (NICM).
- Trial name
- CS-PUFA-02 (NCT01223703)
- Testing
- n-3 PUFAs
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Università degli Studi di Brescia
Heart Failure, Heart Valve Diseases
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
Heart failure (HF) is a condition in which the heart cannot pump blood adequately. It is increasingly common, consumes 4% of the UK National Health Service (NHS) budget and is deadlier than most cancers.
- Conditions
- Heart Failure, Heart Valve Diseases, Atrial Fibrillation, Heart Murmurs
- Trial name
- TRICORDER (NCT05987670)
- Testing
- AI-stethoscope
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Cardiac Surgery, Low Ejection Fraction
Impact of Perioperative Levosimendan on Patients Undergoing Cardiac Surgery With Low Ejection Fraction
to compar levosemindan to other cardiac intropic medications that strengthen the heart in diffrent common adult heart surgery with patients with low ejection fraction(weak heart)
- Trial name
- NCT06784570
- Testing
- levosemindan, adrenaline,noreadrenaline,dopamine and doputamine
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Zagazig University
Chronic Heart Failure, Preserved Ejection Fraction
Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation
Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF.
- Trial name
- CHF-COV-P (NCT05097898)
- Testing
- Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Blood and urine sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
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