Clinical trials: Elderly Adults
Hepatitis E
A Clinical Trial to Evaluate a Recombinant Hepatitis E Vaccine in Healthy Adults
Hepatitis E is characteristic by sporadic and local epidemic around the world, and mainly infects adults aged 15 to 40 years old, resulting in the infection rate ranged from 1% to 15%.
- Trial name
- NCT02603055
- Testing
- 30μg/0.5ml Hepatitis E vaccine, 30μg/0.5ml Recombinant Hepatitis E vaccine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Lifestyle, Healthy, Quality of Life
A Telehealth Lifestyle Intervention for Community-Dwelling Older Adults
The purpose of this study is to evaluate if an occupational therapy lifestyle program for community-dwelling older adults delivered individually through a telehealth platform can produce comparable outcomes in health-related…
- Conditions
- Lifestyle, Healthy, Quality of Life, Aging
- Trial name
- NCT05462626
- Testing
- Holistic Occupational Performance Empowerment (HOPE) Lifestyle Program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Creighton University
Mild Cognitive Impairment, Cognitive Dysfunction
Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve
Normal ageing presents subtle cognitive changes that can be detected before meeting the criteria for Mild cognitive impairment (MCI).
- Trial name
- NCT06279325
- Testing
- Computerized cognitive stimulation program, Face-to-face training-explanatory session
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Older Adults
STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm
Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health.
- Trial name
- STAND-UP (NCT02453204)
- Testing
- Sitting, Standing, Walking
- Where
- 2 sites in United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COVID-19
Clinical Trial of Safety and Immunogenicity of Recombinant SARS-CoV-2 S-Trimer Vaccine (CHO Cells) as Booster Vaccination in Populations Aged 18 to 59 Years
Increased immune escape of emerging SARS-CoV-2 variants and waning neutralizing antibody levels over time indicate the importance of COVID-19 vaccine booster dose.
- Trial name
- NCT05716347
- Testing
- the recombinant SARS-CoV-2 S-Trimer vaccine/inactivated SARS-CoV-2 vaccine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Binhui Biopharmaceutical Co., Ltd.
Gastrointestinal Malignancy
Mobility and Activity Training (MAT) to Optimize Outcomes for Older Adult Abdominal Surgery Patients
In this pilot study a group of older adults undergoing midline laparotomy for gastrointestinal malignancy will participate in a mobility and activity training (MAT) program.
- Trial name
- MAT (NCT02007876)
- Testing
- Mobility and Activity Training
- Where
- 2 sites in United States
- Sponsor
- University of Michigan
Health Promotion Program
Online Resilience Intervention in Older Adults
Resilience in older adults is important for Healthy aging. The purpose of this study was to examine the effectiveness of an on-line program of resilience interventions among older adults.
- Trial name
- NCT05808491
- Testing
- online resilience intervention
- Where
- Taiwan
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Frail Elderly Syndrome, Mild Cognitive Impairment
Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Frail People
The aging of the global population presents significant social and health challenges. In Aragón, 15% of the population is between 65 and 79 years old, and the over-aging index is 16.6%, higher than the national average.
- Trial name
- NCT06438718
- Where
- Spain
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Chronic Kidney Disease (CKD), Health Communication
Patient-centered Precision Medicine Lab Result Communication for Older Adults
For adults ≥65 years and their providers, the investigators will test the usability and design of a tool to replace standard uniform reporting of lab results to patients and their providers with a new personalized Electronic…
- Conditions
- Chronic Kidney Disease (CKD), Health Communication, Patient Comprehension
- Trial name
- NCT07391904
- Testing
- Chronic Kidney Disease (CKD) Lab Result Communication Tool
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of California, Los Angeles
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Influenza
Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Non-Elderly and Elderly Adults
This study will evaluate the safety and immunogenicity of different combinations of A/H1N1 S-OIV (swine flu) vaccine in non-elderly and elderly adults.
- Trial name
- NCT00973349
- Testing
- MF59-eH1N1_f
- Where
- 21 sites in United States, Mexico
- Volunteers
- 2,719 people, healthy volunteers welcome
- Sponsor
- Novartis
Hodgkin Lymphoma, Adult
Elderly Hodgkin Lymphoma Patients Treated With Chemoradiotherapy
Outcome of Hodgkin lymphoma patients over than 60 years treated by chemotherapy and/or radiotherapy: retrospective analysis.
- Trial name
- HODGSA (NCT03535948)
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
Invasive Extraintestinal Pathogenic Escherichia Coli Disease (IED) Prevention
A Study of 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) and High-dose Quadrivalent Influenza Vaccine, With and Without Co-administration, in Adults Aged 65 Years or Older
The purpose of this study is to show that high-dose quadrivalent seasonal influenza vaccine (HD QIV) given together with 9-valent extraintestinal pathogenic Escherichia coli vaccine (ExPEC9V) does not induce lower antibody…
- Trial name
- Engage (NCT06134804)
- Testing
- ExPEC9V, HD quadrivalent influenza vaccine
- Where
- 41 sites in United States, Belgium and 2 more
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Cognitive Impairment, Dementia, Mild
Cognitive Screening Made Easy for PCPs - R33 Phase
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Dementia, Mild, Cognitive Decline
- Trial name
- NCT06162026
- Testing
- RACS app
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Texas at Austin
Physical Activity, Emotions
Lighting and Human Response in Motor Time, Autonomic Nervous System, and Emotion
Light influences on human movement, autonomic nervous system, and emotion. It is inconclusive whether illuminance (Ev) and colour temperature (Tc) is appropriate to human movement, autonomic nervous systme, and emotion.
- Conditions
- Physical Activity, Emotions, Autonomic Nervous System Imbalance
- Trial name
- LiHR (NCT03144791)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gait, Unsteady
At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery
This is a prospective observational study looking at gait-cadence in older adults who are scheduled to have major abdominal surgery at the University of Chicago.
- Trial name
- CADENCE (NCT05886725)
- Testing
- Patients using Step Test Application and Accelerometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Aging
The Efficacy of Oral Mitoquinone (MitoQ) Supplementation for Improving Physiological in Middle-aged and Older Adults
The purpose of this study is to assess the efficacy of supplementation with the mitochondria-targeted antioxidant, mitoquinone (MitoQ), for improving physiological function (vascular, motor, and cognitive) in middle-aged and…
- Trial name
- NCT02597023
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Physical Activity and Wellbeing
Evaluating the Impact of Improvements in Urban Green Space on Older Adults' Physical Activity and Wellbeing: a Natural Experimental Study
Background: Creating or improving urban green space has the potential to be an effective and sustainable way to increase physical activity and improve other aspects of wellbeing in older adults.
- Trial name
- GHIA (NCT03575923)
- Testing
- Urban street greening
- Where
- United Kingdom
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Fall Prevention
Aging and Task-specific Training to Reduce Falls
The goal of this clinical trial is to examine the effects of a novel task-specific balance training for reducing environmental falls in community ambulatory older adults who are at-risk of falling.
- Trial name
- NCT07094659
- Testing
- Task-Specific Balance Training, Treadmill Perturbation Training, Conventional Balance Training
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cognitive Impairment, Physical Functioning
REducing SEDENTary Behaviour May Slow Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Pilot Study
With the nation's fastest growing demographic being adults over 65, one in every three seniors is estimated to die from Alzheimer's Disease (AD).
- Conditions
- Cognitive Impairment, Physical Functioning, Quality of Life
- Trial name
- RESEDENT (NCT03439059)
- Testing
- Reducing Sedentary Behaviour Group
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Western University, Canada