Clinical trials: Elderly Immune Senescence
Asthma
Trial to Compare the Safety, Tolerability and Efficacy of Influenza Virus Vaccine, (CAIV-T) With Influenza Virus in Children With Asthma
Trial to assess asthma exacerbation through to the end of the study; and to demonstrate that the efficacy over one season against culture-confirmed influenza-illness; and finally to assess the safety and tolerability of CAIV-T in…
- Trial name
- NCT00192257
- Testing
- CAIV-T and TIV
- Where
- 2 sites in Belgium
- Volunteers
- 2,229 people
- Sponsor
- MedImmune LLC
Chronic Graft Versus Host Disease
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
This is an open-label, single group, Phase 1/2, 1-arm study for treatment of children aged 1 to <18 years with active moderate-to-severe cGVHD that is refractory to or recurred after at least 2 prior lines of systemic therapy for…
- Trial name
- schoolROCK (NCT07116031)
- Testing
- Belumosudil
- Where
- 35 sites in United States, Belgium and 11 more
- Volunteers
- 37 people
- Sponsor
- Sanofi
Type 1 Diabetes
COVID-19 Pandemic Lockdown Effect in Adolescents and Young Adults With Type 1 Diabetes: Positive Results of an Unpreceded Challenge for Telemedicine and Patient Self-management
Lockdown resulting from the COVID-19 pandemic was an unpreceded model of the impact of lifestyle on chronic diseases, especially for adolescents and young adults with type 1 diabetes (T1D) whose lifestyle is known to strongly…
- Trial name
- COVIDIABADO (NCT04669912)
- Testing
- glucose control and sensor usage
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Sud Francilien
Hepatitis B, Hepatitis A
Long-Term Follow-Up Studies at Year 6, 7, 8, 9, 10: 2 Formulations of Combined Hepatitis A/B Vaccine Compared in Subjects Aged 12-15 Years
To evaluate the persistence of anti-hepatitis A virus (anti-HAV) and anti-hepatitis B surface antigen (anti-HBs) antibodies up to 6, 7, 8, 9 and 10 years after administration of the first dose of the study vaccine.
- Trial name
- NCT00197119
- Testing
- Twinrix™ Adult, Twinrix™ Junior
- Where
- 2 sites in Belgium, Czechia
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Multiple Myeloma, Comprehensive Geriatric Assessment
cGA in Newly-diagnosed Elderly MM Patients: a Multi-center, Prospective, Non-interventional Study.
This is a multi-center, prospective, non-interventional study. Eligible newly diagnosed elderly multiple myeloma (MM) patients will receive comprehensive geriatric assessment (cGA) including ECOG scale, questionaires of…
- Trial name
- NCT03122327
- Testing
- Questionaires
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Immunosenescence
Pilot Study on Effect Size of Non-digestible Polysaccharides (NPS) on Immunity
The aim of the study is to estimate the effect size of a 5-week consumption period of different dietary non-digestible polysaccharides (NPS) on antibody response to influenza vaccination and cellular immunity of healthy…
- Trial name
- Fib-P-2012 (NCT01896154)
- Testing
- NPS
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Clinical Research Center Kiel GmbH
Hepatitis B
A Study on the Safety and Immune Response of AS37 Together With Hepatitis B Antigen in Adults Aged 18-45 Years
This study is conducted to assess safety and immunogenicity of GSK's HBsAg vaccine adjuvanted with GSK's AS37 adjuvant system in healthy, HBs naïve, adults aged 18-45 years and to differentiate GSK's AS37 adjuvant system from…
- Trial name
- NCT05561673
- Testing
- GSK's Hepatitis B vaccine adjuvanted with aluminum hydroxide, GSK's HBsAg candidate vaccine adjuvanted with GSK's AS03 adjuvant system, GSK's Hepatitis B vaccine adjuvanted with GSK's AS04 adjuvant system
- Where
- 5 sites in Belgium, Germany and 1 more
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19, Vaccine Reaction
Modification of the COVID-19 Vaccine Response by an Intervention on the Intestinal Flora
The elderly, who are often in poorer health, have been particularly affected by the COVID-19 pandemic. Recent study results show that while vaccines have been very effective in the short term, protection for the elderly may not…
- Conditions
- COVID-19, Vaccine Reaction, Elderly
- Trial name
- PIRATES-COV (NCT05195151)
- Where
- Canada
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty
Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
The goal of this observational study is to learn whether signs of immune aging and frailty can help predict the balance of benefits and risks of advanced therapies in adults aged 60 years or older with inflammatory bowel disease…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence
- Trial name
- NCT07828886
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Diffuse Large B Cell Lymphoma
Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma
The purpose of this study is to investigate efficacy and safety of R-GemOx Versus R-miniCHOP as first-line treatment of elderly patients with Diffuse large B cell lymphoma
- Trial name
- NCT02767674
- Testing
- Rituximab, Gemcitabine, Oxaliplatin
- Where
- 6 sites in China
- Volunteers
- 258 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy Free-living Elderly
Effect of the Consumption of a Fermented Dairy Drink on the Immune Function
The purpose of this study is to determine whether the regular consumption of the active product enhances the immune function, in comparison to the control product.
- Trial name
- NCT01521182
- Testing
- 1-Fermented Dairy Product (test), 2-Milk-based non-fermented dairy product (control)
- Where
- Belgium
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Acute Lymphoblastic Leukemia
Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia
The main purpose of this study is to determine the maximum tolerated and efficient dose of GRASPA® in combination with polychemotherapy treatment of elderly patients with ALL, 55 years and over, Philadelphia chromosome-negative…
- Trial name
- NCT01523782
- Testing
- GRASPA
- Volunteers
- 30 people
- Sponsor
- ERYtech Pharma
Dermatitis, Atopic
Tacrolimus Ointment Pharmacokinetics in Infants With Atopic Dermatitis
The purpose of this study is to estimate the systemic exposure to tacrolimus in infants with atopic dermatitis after repeated application of tacrolimus ointment.
- Trial name
- NCT00535691
- Testing
- Tacrolimus Ointment 0.03%
- Where
- 8 sites in Canada, Finland and 3 more
- Volunteers
- 53 people
- Sponsor
- Astellas Pharma Inc
Asthma in the Elderly
Asthma in the Elderly: The Role of Vitamin D
We will study whether taking vitamin D improves asthma control and spirometric values in elderly asthmatics.
- Trial name
- NCT01730976
- Testing
- Vitamin D 2,000 I.U.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Asthma
A Safety and Tolerability Study of Arformoterol Tartrate Inhalation Solution in Pediatric Subjects
To determine the safety and tolerability of Arformoterol Tartrate in children with asthma
- Trial name
- NCT00583947
- Testing
- arformoterol, levalbuterol
- Where
- 14 sites in United States
- Volunteers
- 53 people
- Sponsor
- Sumitomo Pharma America, Inc.
Acute Lymphoblastic Leukemia
Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years)
The protocol objective is providing adequate treatment and based on broad consensus in elderly patients with Acute Lymphoblastic Leukemia (ALL).
- Trial name
- NCT01366898
- Testing
- Dexamethasona, Idarubicine, ARA-C, Methotrexate
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- PETHEMA Foundation
Congestive Heart Failure, Angina Pectoris
Randomized Controlled Trial of Health Care to Elderly Patients.
To study the efficacy of multicomponent treatment and care for patients with acute illness or deterioration of a chronic disease at a nursing home in primary health care compared to traditional treatment at hospital.
- Conditions
- Congestive Heart Failure, Angina Pectoris, Asthma, Pneumonia
- Trial name
- NCT00235404
- Testing
- Multicomponent treatment, usual care
- Where
- Norway
- Volunteers
- 142 people
- Sponsor
- Norwegian University of Science and Technology
COVID-19, SARS-CoV-2
A Study to Investigate the Prevention of COVID-19 WithVYD222 in Adults with Immune Compromise and in Participants Aged 12 Years or Older Who Are At Risk of Exposure to SARS-CoV-2
A study to investigate the prevention of COVID-19 with VYD222 in adults with immune compromise and in participants aged 12 years or older who are at risk of exposure to SARS-CoV-2
- Trial name
- NCT06039449
- Testing
- VYD222 (pemivibart), Normal saline
- Where
- 18 sites in United States
- Volunteers
- 790 people
- Sponsor
- Invivyd, Inc.
Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome
This phase II trial studies how well venetoclax and decitabine work in treating participants with acute myeloid leukemia that has come back or does not respond to treatment, or with high-risk myelodysplastic syndrome that has…
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Blastic Plasmacytoid Dendritic Cell Neoplasm, Chronic Myelomonocytic Leukemia
- Trial name
- NCT03404193
- Testing
- Decitabine, Laboratory Biomarker Analysis, Venetoclax
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- M.D. Anderson Cancer Center
Immune Health
Impact of Lactoferrin, a Dietary Supplement, vs. Placebo on Respiratory Tract Infections
This is a randomized, double-blind, placebo-controlled study to evaluate the impact of bovine Lactoferrin (bLf) on respiratory tract infections (RTIs) in an elderly population in the United States.
- Trial name
- NCT04713735
- Testing
- bovine lactoferrin supplement
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition