Clinical trials: Elderly Immune Senescence
Lymphoma, Neurotoxicity
Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00666484
- Testing
- cyclophosphamide, doxorubicin hydrochloride, etoposide
- Where
- 5 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University College, London
RheumatoId Arthritis
The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study
Comparing the cost-effectiveness and safety of additional low-dose glucocorticoid in treatment strategies for elderly patients with rheumatoid arthritis: The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study (GLORIA)
- Trial name
- Gloria (NCT02585258)
- Testing
- Prednisolone
- Where
- 28 sites in Germany, Hungary and 5 more
- Volunteers
- 451 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabetes Mellitus, Type 2, Insulin Resistance
Determinants of Type 2 Diabetes Risk in Middle-aged Black South African Men and Women
There is little known about menopause in African women, whose phenotype differs to Caucasian women, and no data is available on middle-aged black South African men.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Menopause, Hiv
- Trial name
- NCT03408678
- Where
- South Africa
- Volunteers
- 1,025 people
- Sponsor
- University of Witwatersrand, South Africa
Atopic Dermatitis
Study to Assess Efficacy and Safety of Two Regimens of Crisaborole Ointment 2% in Japanese Participants Aged ≥2 Years With Mild to Moderate Atopic Dermatitis
This is a Phase 2b, multi-center, randomized, double-blind, vehicle-controlled, intraparticipant study to evaluate efficacy and safety of two regimens of crisaborole ointment 2% in Japanese pediatric and adult participants…
- Trial name
- NCT03954158
- Testing
- Crisaborole ointment 2%, Vehicle
- Where
- 3 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Pfizer
Immune Function
Prebiotics and Immune Function in Middle Aged Humans
Prebiotics are naturally occurring carbohydrates found in a variety of edible plants. They are not digested by mammalian enzymes, and so reach the gut intact, where they are fermented by some species of intestinal bacteria.
- Trial name
- NCT00898599
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Bypass Grafting, Heart Valve Surgery
VItamin D Metabolism in SEnescent Cardiac Surgery Patients
Advanced age is associated with an increase in postoperative morbidity and mortality in cardiac surgery patients. In detail, compared with younger patients those aged 75 years and older have significantly higher rates of…
- Trial name
- VISE (NCT01378221)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Bacterial Infections, Pneumonia, Pneumocystis Carinii
A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
This study compares 2 different treatments administered to try to prevent serious bacterial infections (such as pneumonia) in HIV-positive children.
- Conditions
- Bacterial Infections, Pneumonia, Pneumocystis Carinii, HIV Infections
- Trial name
- NCT00000811
- Testing
- Azithromycin, Atovaquone, Sulfamethoxazole-Trimethoprim
- Where
- 75 sites in United States, Puerto Rico
- Volunteers
- 690 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Improvement in Immune Cell Function in Healthy Humans
The Effect of Aged Garlic Extract Supplementation on Immune System
The purpose of this study is to determine whether consuming capsules of aged garlic extract is effective in enhancing function of NK and/or γδ T cell resulting in fewer cold and flu symptoms.
- Trial name
- NCT01390116
- Testing
- Aged garlic extract, AGE
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
COVID-19, Chronic Bronchitis
Immunogenicity and Safety of a Third Dose and Immune Persistence of BBIBP-Corv Vaccine in Elderly People With Chronic Bronchitis and COPD
Evaluation of immunogenicity, safety and persistence of the subjects aged 60 years and above with chronic bronchitis and chronic obstructive pulmonary disease received the third dose of inactivated COVID-19 vaccine .
- Conditions
- COVID-19, Chronic Bronchitis, COPD
- Trial name
- NCT05104216
- Testing
- Inactivated COVID-19 vaccine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Biotec Group Company Limited
Tinnitus, Subjective
Efficacy Study for Development and Use of Neurofeedback-trainings for Patients Suffering From Chronic Tinnitus
Chronic tinnitus affects about 10-15% of the population in industrialized countries. Investigations of the brain activity by using electroencephalography (EEG) showed that in localized regions of the hearing system brain activity…
- Trial name
- NCT02383147
- Testing
- Tomographic Neurofeedback, Non Tomographic Neurofeedback
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- University of Zurich
Multiple Myeloma
Subcutaneous Velcade Plus Oral Melphalan and Prednisone or Plus Cycloposphamide and Prednisone or Plus Prednisone
This protocol is a single-arm, three-cohort, phase II multicenter study designed to assess the safety and the efficacy of three all-oral combinations: Velcade with continuous low-dose melphalan and prednisone (VMP) or with…
- Trial name
- NCT01190787
- Testing
- velcade subcutaneous melphalan prednisone, velcade cyclophosphamide prednisone, velcade prednisone
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Myeloma Network B.V.
Acute Lymphoblastic Leukemia
Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years)
The protocol objective is providing adequate treatment and based on broad consensus in elderly patients with Acute Lymphoblastic Leukemia (ALL).
- Trial name
- NCT01366898
- Testing
- Dexamethasona, Idarubicine, ARA-C, Methotrexate
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- PETHEMA Foundation
Rhinitis, Allergic, Perennial
Fexofenadine Study On Filipino Children for The Relief of Perennial And Intermittent Allergic Rhinitis
To determine the safety and efficacy of Fexofenadine (Telfast®) 30mg pediatric tablets on Filipino children aged 6 to 11 for the relief of symptoms associated with perennial and intermittent allergic rhinitis.
- Trial name
- NCT00741897
- Testing
- Fexofenadine
- Where
- Philippines
- Volunteers
- 264 people
- Sponsor
- Sanofi
Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome
Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
This trial will assess the safety, efficacy and tolerability of ACZ885 in patients aged 4 years and younger with cryopyrin associated periodic syndromes (CAPS)
- Conditions
- Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease
- Trial name
- NCT01302860
- Testing
- ACZ885
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 17 people
- Sponsor
- Novartis Pharmaceuticals
Humoral Immune Response
Study to Evaluate Safety and Pharmacokinetics of BIVIGAM® in Primary Immune Deficiency Subjects Aged 2 to 16
This study is part of the BIVIGAM® post marketing requirement (PMR). It is being conducted in subjects aged 2-16 with primary immune deficiency disorders associated with defects in humoral immunity to generate additional data on…
- Trial name
- NCT03164967
- Testing
- Bivigam
- Where
- 8 sites in United States
- Volunteers
- 16 people
- Sponsor
- ADMA Biologics, Inc.
Measles, Measles-Mumps-Rubella+Chickenpox Vaccine
A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age
This study is evaluating the immunogenicity and safety of intramuscular administration of the investigational MMRVNS vaccine compared to intramuscular administration of the MMRV (Merck's measles, mumps, rubella and varicella)…
- Trial name
- NCT07406360
- Testing
- MMRVNS, MMRV
- Where
- 17 sites in United States
- Volunteers
- 1,209 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Antibodies Involved in Healthy Aging
Wellderly Immune Antibodies Study, a Sub-Study of Healthy Elderly Active Longevity (HEAL) Cohort
The aim of this sub-study is to determine whether healthy individuals over 90 years of age possess immune cells that are involved in protection from chronic disease.
- Trial name
- NCT01816880
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Scripps Translational Science Institute
Asthma
Long-Term Safety of Symbicort in Asthmatic Children - SAPLING
The purpose of this study is to assess the safety of Symbicort compared to Pulmicort in asthmatic children aged 6 to 11 years
- Trial name
- NCT00646529
- Testing
- budesonide/formoterol (Symbicort), budesonide (Pulmicort)
- Volunteers
- 175 people
- Sponsor
- AstraZeneca
Moderate-to-Severe Atopic Dermatitis
Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants With Moderate-to-Severe Atopic Dermatitis
The purpose of this study was to assess the pharmacokinetics (PK), safety, and efficacy of nemolizumab in pediatric participants with moderate-to-severe atopic dermatitis (AD).
- Trial name
- NCT04921345
- Testing
- Nemolizumab
- Where
- 23 sites in United States, Denmark and 3 more
- Volunteers
- 109 people
- Sponsor
- Galderma R&D
Diffuse Large B-cells Non-Hodgkin Lymphoma
A Phase II Study of the FIL on Elderly Frail Patients With DLBCL
A phase II study to evaluate the combination of Lenalidomide and Rituximab as front line therapy for the treatment of elderly frail patients evaluated in CGA with Diffuse Large B-cells non-Hodgkin Lymphoma.
- Trial name
- NCT02955823
- Testing
- Rituximab-Dexamethasone-Lenalidomide
- Where
- 18 sites in Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Italiana Linfomi - ETS