Clinical trials: Elderly Lymphoma Patients
Acute Lymphocytic Leukemia
Treatment of Philadelphia-Positive Acute Lymphocytic Leukemia (Ph+ ALL) in the Elderly With Imatinib Mesylate (STI571) and Chemotherapy.
ALL patients aged 55 years or older were treated with steroids during one week and Ph+ve cases were then offered a specific therapy including an induction treatment with steroids, cyclophosphamide, daunorubicin and vincristine…
- Trial name
- NCT00149136
- Testing
- imatinib
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Leukemia, Lymphoblastic, Acute
Dasatinib and Low Intensity Chemotherapy for Ph+ Acute Lymphoblastic Leukemia
1. The use of imatinib in combination or in association with chemotherapy is now considered as the gold standard for the treatment of Ph+ ALL. The complete remission (CR) rate is 90% versus 20% to 40% with chemotherapy alone.
- Trial name
- EWALLPH01 (NCT02888990)
- Testing
- Dasatinib
- Where
- 64 sites in Belgium, France and 2 more
- Volunteers
- 71 people
- Sponsor
- Versailles Hospital
Follicular Lymphoma
Brief Chemoimmunotherapy With R+B+M Followed by R in Elderly Patients Advanced Stage Untreated Follicular Lymphoma
This is a prospective, multicenter phase II trial designed to determine efficacy and safety of a brief chemoimmunotherapy with the combination of Rituximab + Bendamustine + Mitoxantrone in elderly patients with advanced stage…
- Trial name
- FLE09 (NCT01523860)
- Testing
- Rituximab, Mitoxantrone, Bendamustine
- Where
- 37 sites in Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Philadelphia Chromsome Positive Acute Lymphoblastic Leukemia
Evaluation of Efficacy and Safety of Nilotinib in Combination With Chemotherapy in Elderly Patients With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
The goal of this trial is to evaluate the efficacy and the tolerance of the combination of nilotinib with chemotherapy in the front-line setting as induction and consolidation therapy in Ph+ ALL patient aged 55 years and over.
- Trial name
- NCT01528085
- Testing
- Nilotinib
- Where
- 69 sites in France, Germany and 1 more
- Volunteers
- 79 people
- Sponsor
- Goethe University
Lymphoma
Radiation Therapy and High-Dose Corticosteroids in Treating Older Patients With Primary CNS Non-Hodgkin's Lymphoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with a corticosteroid, such as dexamethasone, may be an effective treatment for non-Hodgkin's lymphoma.
- Trial name
- NCT00003278
- Testing
- dexamethasone, radiation therapy
- Where
- 14 sites in United States, Canada
- Volunteers
- 28 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Lymphoma
Rituximab and Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them.
- Trial name
- NCT00278421
- Testing
- rituximab, cyclophosphamide, doxorubicin hydrochloride
- Where
- 78 sites in Germany, Israel and 1 more
- Volunteers
- 592 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Adult Solid Neoplasm, Toxicity
Geriatric Assessment Intervention for Reducing Toxicity in Older Patients With Advanced Cancer
This cluster randomized clinical trial compares a geriatric assessment intervention with usual care for reducing cancer treatment toxicity in older patients with cancer that has spread to other places in the body.
- Conditions
- Adult Solid Neoplasm, Toxicity, Lymphoma
- Trial name
- NCT02054741
- Testing
- Comprehensive Geriatric Assessment, Quality-of-Life Assessment, Survey Administration
- Where
- 23 sites in United States
- Volunteers
- 733 people
- Sponsor
- Supriya Mohile
Lymphoma, Refractory B-Cell Lymphoma
Study of CAR-T Therapy in Older Patients
This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life.
- Conditions
- Lymphoma, Refractory B-Cell Lymphoma, Lymphoma, B-Cell, DLBCL NOS
- Trial name
- NCT04300998
- Testing
- Activities of Daily Living/ADLs, Instrumental Activity of Daily Living, Timed Up and Go
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoma
Rituximab and Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With B-Cell Non-Hodgkin's Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them.
- Trial name
- NCT00278408
- Testing
- filgrastim, rituximab, cyclophosphamide
- Where
- 152 sites in Denmark, Germany and 2 more
- Volunteers
- 700 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Acute Lymphoblastic Leukemia
EWALL-PH OBSERVARTORY 2022
An observatory for patients aged 18 years and over with Philadelphia chromosome positive (Ph+ or BCR::ABL1) acute lymphoblastic leukemia (ALL) and treated with the combination of BCR::ABL1 inhibitors and chemotherapy and/or…
- Trial name
- Ewall Obs 2022 (NCT07684131)
- Where
- 23 sites in France
- Volunteers
- 100 people
- Sponsor
- Versailles Hospital
Central Nervous System Neoplasms, Primary
Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma
This study will compare the overall survival (OS) time of elderly patients who would not tolerate standard chemotherapy for PCNSL treated with WBXRT together with Optune-TTF to those treated with whole-brain radiotherapy alone.
- Trial name
- NCT03530605
- Testing
- Optune TTF device
- Sponsor
- Saint Luke's Health System
Cognitive Impairment
Health Care Courses of Elderly Hospitalized Patients for Inappropriate Reasons: Qualitative and Economic Analyzes
For almost 17 % of cases patients over 75 years are sent for inappropriate reasons to the emergency unit. They are described as inappropriate hospitalization because they don't require the use of technical platform or diagnostic…
- Trial name
- PAGE (NCT02749669)
- Testing
- Qualitative research
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Régis AUBRY
Diffuse Large B Cell Lymphoma
Pola-R2 in Newly Diagnosed Non-fit Elderly DLBCL Patients
This is a prospective, single-arm, phase II study, and the purpose of this study is to evaluate the efficacy and safety of Pola-R2 regimen in newly diagnosed elderly diffuse large B cell lymphoma classified into un-fit or frail…
- Trial name
- NCT06176729
- Testing
- Polatuzumab Vedotin, Rituximab, Lenalidomide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yan Zhang, MD
Adult Acute Lymphocytic Leukemia
Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia
The aim of this study is to test feasibility and efficacy of a dose reduced chemotherapy in elderly patients with newly diagnosed acute lymphoblastic leukemia.
- Trial name
- NCT00199095
- Testing
- Adriamycin, Cyclophosphamide, Cytarabine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Goethe University
Lymphoma
Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing…
- Trial name
- NCT00052936
- Testing
- filgrastim, rituximab, CHOP regimen
- Where
- 174 sites in Germany, Switzerland
- Volunteers
- 1,506 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Hodgkin Lymphoma
A Multi-centre Study of MBVD in Elderly and/or Cardiopathic Patients Affected by Hodgkin's Lymphoma (HL)
The study has the purpose to evaluate in elderly and/or cardiopathic HL patients, the cardiologic toxicity of the MBVD regimen, where liposomal doxorubicin (Myocet®) is substituted for doxorubicin in the conventional ABVD regimen.
- Trial name
- HD0803 (NCT01523847)
- Testing
- MBVD (Myocet+BVD)
- Where
- 26 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Follicular Lymphoma
BRIEF Bendamustine and Rituximab In Elderly Follicular
The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular…
- Trial name
- BRIEF (NCT01313611)
- Testing
- Rituximab + bendamustine
- Where
- 117 sites in Belgium, France
- Volunteers
- 62 people
- Sponsor
- The Lymphoma Academic Research Organisation
Non-Hodgkin's Lymphoma
Non-Hodgkin Lymphoma in Elderly Patients Above the Age of 80 in the Rituximab Era
This is an exploratory analysis that is investigating the pattern of care in patients over the age of 80 who were diagnosed with non-Hodgkin lymphoma (NHL).
- Trial name
- NCT00902434
- Volunteers
- 50 people
- Sponsor
- Oncology Specialists, S.C.
Acute Lymphoblastic Leukemia
Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia
The main purpose of this study is to determine the maximum tolerated and efficient dose of GRASPA® in combination with polychemotherapy treatment of elderly patients with ALL, 55 years and over, Philadelphia chromosome-negative…
- Trial name
- NCT01523782
- Testing
- GRASPA
- Volunteers
- 30 people
- Sponsor
- ERYtech Pharma