Clinical trials: Elderly Patients
Acute Congestive Heart Failure, Exacerbation of COPD
The RAD-HOME Project: a Pilot Study of Domiciliary Teleradiology
Aim of the study is to assess feasibility and safety of a public territorial radiology service for home hospitalized frail elderly patients whose health conditions discourage the transportation to hospital.
- Conditions
- Acute Congestive Heart Failure, Exacerbation of COPD, Pneumonia, Fractures
- Trial name
- RHP (NCT01098916)
- Testing
- Home X-rays, X-rays in hospital
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Colorectal Disorders, Surgery
Surgery in Persons of Older Age
Surgery in persons of older AGE (SAGE) is an observational study of patients aged 60 years and older undergoing major colorectal surgery.
- Conditions
- Colorectal Disorders, Surgery, Old Age; Debility, Quality of Life
- Trial name
- SAGE (NCT01924585)
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Hyperalgesia, Cataract Bilateral Nos
Gabapentin Pretreatment for Staged Bilateral Cataract Operations
To evaluate the effect of oral gabapentin premedication on hyperalgesia in elderly patients undergoing staged bilateral cataract operations under monitored anesthesia care
- Trial name
- NCT03826615
- Testing
- Gabapentin
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Femoral Fracture, Cognition Disorders
Influence of Intrathecal Dexamethasone Administration for Proximal Femoral Fractures
Spinal anesthesia blocks acute pain in older patients with femur fracture. Delirium is a common complication seen after femur fracture, affecting approximately 10-16% of patients.
- Conditions
- Femoral Fracture, Cognition Disorders, Cortisol; Hypersecretion
- Trial name
- NCT03856502
- Testing
- 8 mg of dexamethasone, 12,5 mg of 0,5 % of levobupivacaine
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- General Hospital Sveti Duh
Fraility, Hypotension
The Effect of Frailty on Hypotension After Anesthesia Induction
Frailty is defined as a state of weakness resulting from a decrease in physiological reserves due to physiological changes, diseases, and/or malnutrition associated with advancing age.
- Trial name
- NCT07351552
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Breast Neoplasms
Pegylated Liposomal Doxorubicin (Caelyx(R)) as Monotherapy in Elderly Patients With Locally Advanced and/or Metastatic Breast Cancer (Study P05059)
The purpose of this study is to evaluate the safety and efficacy of pegylated liposomal doxorubicin (Caelyx) in elderly patients who are to receive first-line chemotherapy for metastatic or locally advanced breast cancer, not…
- Trial name
- NCT00604968
- Testing
- Caelyx (pegylated liposomal doxorubicin; SCH 200746)
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Neck Pain
Magnetic Resonance Imaging Study on Young and Middle-aged Patients With Cervical Spondylotic Pain
Cervical and shoulder pain in young adults is commonly caused by intervertebral disc degeneration, bulge or herniation. Disc degeneration includes the synthetic and degradative imbalance of myxoid matrix, degeneration of annulus…
- Trial name
- MRI-CervPain (NCT06217029)
- Testing
- physiotherapy and maxillary traction
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Delirium - Postoperative
The Effect of Aromatherapy on Delirium in Critically Elderly Patients Undergoing Fracture Surgery
The aim of this quasi-experimental study was to examine the effect of lavender aromatherapy on delirium in patients who underwent fracture surgery, were in intensive care, and were over 60 years old.
- Trial name
- NCT06772129
- Testing
- Aromatherapy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Senay Gokdemir
Coronary Artery Disease, Elderly (Aged >70)
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
This study is a prospective multi-center observational cohort involving elderly patients (≥70 years old) with multi-vessel coronary disease identified by coronary computed tomography angiography (cCTA) and scheduled for invasive…
- Trial name
- NCT07311954
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 800 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cancer
Fragmentation of Elastin as a Biological Marker of Frailty and Impact in Tumor Progression in Elderly Patients With Cancer
The aim of the study is to evaluate frailty in patients aged ≥ 65 years with cancer. The elderly population is very heterogeneous, it is necessary to evaluate these elderly patients before treatment to assess the risk-benefit…
- Trial name
- AgElOn (NCT02807129)
- Testing
- blood withdrawn, urine collection
- Where
- France
- Volunteers
- 296 people
- Sponsor
- CHU de Reims
Proximal Humeral Fracture
Paravertebral Block for Proximal Humeral Fracture Surgery
This study evaluates the effects of T2 paravertebral block block improving interscalene brachial plexus block and superficial cervical plexus block on the relief of pain intensity during elderly proximal humerus fracture fixation…
- Trial name
- NCT03919422
- Testing
- T2 paravertebral block, interscalene brachial plexus block and superficial cervical plexus block
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital
Hypertension, Renal Insufficiency
Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency
The purpose of this study is to evaluate the effects of indapamide SR 1.5 mg on renal function, endothelial function, blood pressure variability by comparison with hydrochlorothiazide 25 mg, in patients with Mild to Moderate…
- Trial name
- NCT01172431
- Testing
- Indapamide, Hydrochlorothiazide
- Where
- China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Cancer
Antineoplastic Drugs in Elderly Patients
The purpose is to study the population pharmacokinetics, effectiveness and safety of antineoplastic drugs (Busulfan, Paclitaxel, Afatinib, Ceritinib, Crizotinib, Imatinib, Lapatinib, etc) in elderly patients and recommend…
- Trial name
- NCT05467189
- Testing
- Busulfan, Paclitaxel, Afatinib, Ceritinib, Crizotinib (Antineoplastic drugs)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Serious Injury, Communication
A Communication Tool to Improve Communication in the ICU
The purpose of this study is to test the effectiveness of the Best Case/Worst Case-ICU communication tool on quality of communication, clinician moral distress, and ICU length of stay for older adults with serious traumatic…
- Trial name
- NCT05780918
- Testing
- Best Case/Worst Case-ICU Communication Tool
- Where
- 8 sites in United States
- Volunteers
- 7,320 people
- Sponsor
- University of Wisconsin, Madison
Geriatrics, Chronic Kidney Disease
Evaluation of Endothelial Dysfunction in Geriatric Non-dialysis Chronic Kidney Disease Patients
Brief summary template The goal of this clinical trial is to assess endothelial dysfunction in geriatric non-dialysis CKD patients.
- Conditions
- Geriatrics, Chronic Kidney Disease, Carotis Intima-media Thickness
- Trial name
- EDGeriatrCKD (NCT07430982)
- Testing
- Ultrasonographic and Capillary Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Muğla Sıtkı Koçman University
Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances
TEAS on Sleep Quality and POCD in Elderly Patients
Elderly patients are often considered as a high-risk population for major abdominal surgery due to reduced functional reserve and increased comorbidities.
- Conditions
- Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances, Postoperative Cognitive Dysfunction, Elderly Patients
- Trial name
- NCT04850196
- Testing
- TEAS, control group
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Elderly, Frail
Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients.
- Conditions
- Elderly, Frail, Gastric Cancer, Prehabilitation
- Trial name
- NCT06510088
- Testing
- 3-week multimodal prehabilitation program
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Prostatic Neoplasms
Aggressive Prostate Cancers in Elderly Patients
Patients aged 70 years or older had a higher possibility of high risk cancer than younger patients.
- Trial name
- NCT01347476
- Where
- South Korea
- Volunteers
- 1,333 people
- Sponsor
- Seoul National University Hospital
Diffuse Large B-Cell Lymphoma
Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL
The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise…
- Trial name
- ACRUE (NCT05952024)
- Testing
- Acalabrutinib, Rituximab
- Where
- 57 sites in United States, Brazil and 3 more
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Frailty
Meal Delivery and Exercise
The purpose of this study is to evaluate the effects of a home-based exercise program administered through Meals on wheels (MOW) on gait speed and frailty status and to assess the association between novel serum biomarkers (70…
- Trial name
- NCT04906759
- Testing
- Meals plus exercise, Meals only
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston