Clinical trials: Elective Cardiac Surgery, open to volunteers
Minimally Invasive Coronary Revascularization Surgery, Elective Surgery
Impact of Total Coronary Revascularization Via Left Anterior Thoracotomy (TCRAT) vs. Robotic-Assisted Harvesting of LIMA (ITcrats)
The two types of total coronary revascularization via left anterior thoracotomy (TCRAT) might have their potential benefits and disadvantages.
- Trial name
- ITcrats (NCT06988735)
- Testing
- Nonrobotic TCRAT, Robotic TCRAT
- Where
- Saudi Arabia
- Volunteers
- 182 people
- Sponsor
- Mohamed R El Tahan
Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass
Evaluation of the Effectiveness of Ultrasound-Guided Stellate Ganglion Block in Cardiac Surgery Anesthesia on Postoperative Recovery
Heart surgery is a complex and delicate procedure that affects more than one million people worldwide each year. Patients who undergo this surgery are generally elderly and have multiple comorbidities, which places them in…
- Conditions
- Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass, CPB
- Trial name
- ECLAIR (NCT07676487)
- Testing
- Elective surgery (≥ 24 hours) with cardiopulmonary bypass (more than 2 procedures)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Blood Pressure
Non-Invasive Blood Pressure Monitoring
The purpose of this study is to evaluate an alternative way of continuously measuring blood pressure in patients coming for complex surgery.
- Trial name
- NCT05825937
- Testing
- ClearSight System
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Saskatchewan
AKI - Acute Kidney Injury
Efficacy and Safety of SP16 in Preventing Acute Kidney Injury in At-risk Subjects With Chronic Kidney Disease Undergoing Elective Cardiac Surgery Using the Heart-lung-machine
This clinical study investigates the safety and potential effectiveness of the investigational drug SP16 in preventing acute kidney injury in patients with pre-existing chronic kidney disease who are undergoing cardiac surgery…
- Trial name
- EASE-AKI (NCT07661940)
- Testing
- SP16-3M
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Postoperative Pain
Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute…
- Trial name
- NCT07063108
- Testing
- Esketamine hydrochloride, Saline
- Volunteers
- 276 people
- Sponsor
- Chinese PLA General Hospital
Preoperative Care, Surgery--Complications
Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study
The proportion of noncardiac surgeries performed as same-day surgery is increasing worldwide, with more complex surgeries being performed on higher risk patients in the outpatient setting.
- Conditions
- Preoperative Care, Surgery--Complications, Myocardial Infarction
- Trial name
- VALIANCE (NCT04973397)
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
CABG, Respiratory Insufficiency
Early Postoperative Physiotherapy to Prevent Respiratory Insufficiency After Elective Heart Surgery
This study aims to determine whether starting respiratory physiotherapy one hour after removal of the breathing tube following elective coronary artery bypass graft (CABG) surgery leads to better recovery than the current…
- Conditions
- CABG, Respiratory Insufficiency, Postoperative Pulmonary Complications (PPCs)
- Trial name
- EPP-CABG (NCT07730034)
- Testing
- Early postoperative physiotherapy, Standard postoperative care
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Dijana Filipović
Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction
Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.
Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery.
- Conditions
- Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction, Mechanical Ventilation Strategies
- Trial name
- APRV-OBESE-CS (NCT07409324)
- Testing
- Airway Pressure Release Ventilation (APRV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Elective Heart Surgery
Ear Acupressure for Reducing Anxiety and Pain During Heart Surgery
Acupuncture and acupressure, rooted in Traditional Chinese Medicine, are used to treat a variety of symptoms. One specific and easy-to-apply method is ear acupuncture/acupressure following the NADA protocol (developed by the…
- Trial name
- NCT07010003
- Testing
- Acupressure
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University Hospital Tuebingen
Postoperative Pain, Cardiac Surgery
Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is often associated with significant postoperative pain. Poor pain control after sternotomy may increase opioid use, delay mobilization, prolong extubation time, and…
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Pain After Cardiac Surgery Via Median Sternotomy
- Trial name
- SPARE-CABG (NCT07498946)
- Testing
- Thoracic paravertebral block (TPVB), Bilateral Deep Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Atrial Fibrillation (AF), VTE
Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure
PAUSE 2 study is a prospective, open-label, blinded-endpoint non-inferiority RCT of PAUSE vs. ASRA management in DOAC treated high risk patients with AF/VTE who need elective high bleed risk surgery/procedure and/or any procedure…
- Trial name
- PAUSE 2 RCT (NCT06957366)
- Testing
- PAUSE Perioperative DOAC Management, ASRA Perioperative DOAC Management
- Where
- 14 sites in United States, Belgium and 2 more
- Volunteers
- 920 people
- Sponsor
- McMaster University
Post Induction Hypotension, Postoperative Morbidity
Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery
This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for…
- Trial name
- NCT07488182
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Necmettin Erbakan University
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Cardiac Surgery, Prehabilitation
Prehabilitation Program for Patients Awaiting Elective Heart Surgery at Increased Risk of Postoperative Complications: Feasibility and Potential Clinical Outcomes
The goal of this study is to learn if an exercise-based prehabilitation program can help people who are waiting for heart surgery and are at higher risk of complications recover better.
- Conditions
- Cardiac Surgery, Prehabilitation, Postoperative Complications
- Trial name
- PRÉAD-CARDIAQU (NCT07144722)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Montreal Heart Institute
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischaemic Heart Disease, Prehabilitation
CABGpreHAB - a Feasibility Study Protocol
Patients with ischemic heart disease (IHD) awaiting coronary artery bypass graft (CABG) surgery often face challenges like advanced age, frailty, comorbidities, and physical inactivity.
- Conditions
- Ischaemic Heart Disease, Prehabilitation, Coronary Artery Bypass, Feasibility Studies
- Trial name
- NCT07035171
- Testing
- Multimodal prehabilitation intervention, Control (Standard treatment)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrial Fibrillation (AF)
Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)
The purpose of the PAUSE-Virtual Study is to show that by changing pre-surgery visits with patients taking a blood thinner (direct oral anticoagulant (apixaban, dabigatran, edoxaban, rivaroxaban or warfarin) when the participant…
- Trial name
- PAUSEVirtual (NCT06844227)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,780 people
- Sponsor
- McMaster University