Clinical trials: Elective Spine Surgery
Postoperative Pain After Spinal Surgery
Compined Lumber Longissimus Plane Block and Multifidus Longissimus Plane Block Versus Infiltration Field Block in Lumber Spine Surgery
Lumbar spine surgery is one of the most commonly performed procedures for degenerative spinal disorders, including lumbar disc herniation, spinal stenosis, and degenerative disc disease.
- Trial name
- LLP/MLP (NCT07681648)
- Testing
- Ultrasound-Guided Bilateral Combined LLP and MLP Block, [Ultrasound-Guided Bilateral Combined LLP and MLP Block], [Conventional Wound Infiltration with Bupivacaine]
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Engy Emil
Staphylococcus Aureus, Colonization, Asymptomatic
Decolonization Efficacy of Polyhexanide vs. Mupirocin
This pilot randomized controlled trial evaluates the feasibility, tolerability, and preliminary efficacy of a decolonization regimen using polyhexanide in reducing Staphylococcus aureus colonization in the preoperative phase of…
- Trial name
- SPADE (NCT06633588)
- Testing
- Polyhexanide, Mupirocin and Chlorhexidine
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Mean Blood Pressure
Phentolamine Versus Magnesium Sulphate Infusion During Elective Lumbar Spine Surgery: a Randomized Double Blind Comparative Study
The aim of this study is to evaluate the efficacy of controlled hypotensive anesthesia with phentolamine versus Magnesium sulfate in patients undergoing lumbar spine fusion surgery on blood loss, total dose of hypotensive agents…
- Trial name
- NCT04269980
- Testing
- MAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Orthosis
Semirigid Cervical Collar and Nasotracheal Intubation by Glidescope in Cervical Spine Surgery
Effect of semirigid cervical collar during nasotracheal intubation by Glidescope in the elective cervical spinal surgical patients: a study of clinical predictors and outcomes
- Trial name
- NCT03210922
- Testing
- Miami cervical collar
- Where
- Taiwan
- Volunteers
- 181 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Lumbar Spine Pathology, Elective Spine Surgery
Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery
Having spine surgery and recovery is a vulnerable period when opioid naive patients may transition into long-term use of opioids, and when previously opioid tolerant patients may be at risk to continue towards long-term opioid…
- Trial name
- NCT06288256
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Fluid Management During Elective Spine Surgeries
Conventional Fluid Management vs Plethysmographic Variability Index -Based Goal Directed Fluid Management
Plethysmographic variability index is a dynamic method for evaluation of volume status which depends on estimation of respiratory variations in pulse oximeter waveform amplitude.
- Trial name
- NCT05239286
- Testing
- General anaesthesia, Conventional fluid managment, PVI dependant goal directed fluid therapy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Post-Operative Pain
Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery
The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory drugs (NSAID) such as celecoxib were used as a part of multimodal analgesia to control such pain.
- Trial name
- NCT04342065
- Testing
- Celecoxib capsules, Pregabalin 150mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- South Egypt Cancer Institute
Surgery, Brain Tumor
Neurosurgical Transitional Care Programme
Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery.
- Conditions
- Surgery, Brain Tumor, Brain Tumor, Recurrent, Brain Pathology
- Trial name
- TCP (NCT03593330)
- Testing
- Transitional Care Programme
- Where
- United Kingdom
- Volunteers
- 242 people
- Sponsor
- Barts & The London NHS Trust
Elective Spine Surgery Receiving Pre and/or Postoperative Pain Control With Opioids
Impact of Daily, Digital and Behavioral Tele-health Tapering Program for Perioperative Surgical Patients Exposed to Opioids and Benzodiazepines.
The purpose of this study is to examine the safety, acceptability, and feasibility of a controlled taper off of opioids and/or benzodiazepines, with the use of behavioral health tele-health based therapy services, in the…
- Trial name
- NCT04787692
- Testing
- Opioid and Benzodiazepine Naive-patients, Opioid and Benzodiazepine Tolerant-patients
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spine Surgery
Tranexamic Acid Infusion During Elective Spine Surgery
Tranexamic acid (TXA) is an agent that has been shown to be safe and effective to reduce blood loss in surgical procedures. The purpose of the study is to assess the effect of transexamic on elective decompressive lumbar spine…
- Trial name
- NCT04312880
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Albany Medical College
Pharmacological Action
The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.
In this randomized double blind placebo controlled study of tranexamic acid during minor spinal surgery, mean postoperative blood loss in the patients who received TXA was statistically significantly lower compared to placebo.
- Trial name
- NCT03714360
- Testing
- Tranexamic Acid, Sodium Chloride 0,9%
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Mikkel Østerheden Andersen
Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol…
- Trial name
- NCT07822295
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Pain, Postoperative
Safety and Efficacy Study of Fentanyl Iontophoretic Transdermal System (ITS) for Management of Moderate to Severe Acute Pain in Participants Who Have Undergone Elective Spine or Orthopedic Surgery
The purpose of this study is to evaluate in daily clinical practice the safety and efficacy of fentanyl Iontophoretic Transdermal (through the skin) System (ITS) for management of moderate (medium level of seriousness) to severe…
- Trial name
- NCT00779038
- Testing
- Fentanyl ITS
- Where
- 3 sites in Belgium
- Volunteers
- 13 people
- Sponsor
- Janssen Cilag N.V./S.A.