Clinical trials: Elective Surgeries
Arthroplasty, Replacement, Knee
A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery
The purpose of this study is to determine the efficacy of JNJ-70033093 in preventing total venous thromboembolism (VTE) events (proximal and/or distal deep vein thrombosis [DVT] [asymptomatic confirmed by venography assessment or…
- Trial name
- AXIOMATIC-TKR (NCT03891524)
- Testing
- JNJ-70033093 25 mg, JNJ-70033093 50 mg, JNJ-70033093 100 mg
- Where
- 117 sites in United States, Argentina and 16 more
- Volunteers
- 1,242 people
- Sponsor
- Janssen Research & Development, LLC
Hemorrhage
The Fibrin Pad Liver Study
The objective of this study is to evaluate the safety and and hemostatic effectiveness of the Fibrin Pad (FP) versus standard of care treatment (SoC) in controlling parenchymal bleeding during hepatic surgery.
- Trial name
- NCT01166243
- Testing
- Fibrin Pad, Standard of Care
- Where
- 9 sites in Australia, Germany and 3 more
- Volunteers
- 84 people
- Sponsor
- Ethicon, Inc.
Burns, Traumatic Lesions
Determine the Haemostatic Efficacy of TT-173, Reducing the Bleeding Time in the Donor Site of Skin Grafting
The purpose of this study is to determine the haemostatic efficacy of TT-173, reducing the bleeding time in the donor site of skin grafting.
- Trial name
- EHTIC (NCT02012569)
- Testing
- TT-173
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Thrombotargets Europe S.L
Thrombocytopenia Associated With Chronic Liver Disease
Phase 3 Study of rhTPO for Thrombocytopenia in Chronic Liver Disease Patients Undergoing Elective Invasive Procedures.
This is a global, multicenter, randomized, double-blind, placebo-controlled study using recombinant human thrombopoietin stimulating factor ( rhTPO) to treat adults with Chronic liver disease-related thrombocytopenia (CLDT).
- Trial name
- NCT07911800
- Testing
- rhTPO
- Where
- 2 sites in Georgia
- Volunteers
- 150 people
- Sponsor
- MIBIO PTE. LTD.
Acute Normovolemic Hemodilution
Clinical Study on the Effectiveness and Safety of Succinylated Gelatin Injection
The succinylated gelatin injection (specification: 500 mL: 20 g) developed and produced by Nanjing Chia-tai Tianqing Pharmaceutical..
- Trial name
- NCT06977763
- Testing
- succinylated gelatin injection 1, succinylated gelatin injection
- Volunteers
- 104 people
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
General Anaesthesia
Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia
The purpose of this study was to perform comparative evaluation of clinical efficacy and safety of Remimazolam and Propofol for induction and maintenance of general anesthesia in patients undergoing elective surgery under general…
- Trial name
- NCT03669484
- Testing
- Remimazolam, Propofol, Fentanyl
- Where
- 6 sites in Russia
- Volunteers
- 150 people
- Sponsor
- R-Pharm
Parenteral Nutrition
Efficacy and Safety of a Fish Oil Containing Lipid Emulsion
The purpose of the study is to compare a fish oil containing lipid emulsion against a medium-chain/long-chain triglyceride (MCT/LCT) lipid emulsion in terms of their efficacy and safety during postoperative parenteral nutrition.
- Trial name
- NCT01176695
- Testing
- fish oil containing lipid emulsion, MCT/LCT containing lipid emulsion
- Where
- 2 sites in China
- Volunteers
- 240 people
- Sponsor
- B. Braun Melsungen AG
Prevention of Arterial and Venous Thrombosis
A Clinical Study of SHR-2004 Injection in Preventing Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty
The purpose of the study is to evaluate the efficacy and safety of SHR-2004 in preventing venous thromboembolism after elective unilateral total knee arthroplasty.
- Trial name
- NCT06825416
- Testing
- SHR-2004 injection, Enoxaparin sodium injection
- Where
- 2 sites in China
- Volunteers
- 1,165 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Analgesia
Efficacy and Safety of HSK21542 in Inducing Postoperative Analgesia in Undergoing Elective Laparoscopic Surgery
This is a multicenter, randomized, double-blind, placebo-controlled, two-stage phase II clinical study. The main objective is to evaluate the efficacy and safety of HSK21542 injection and explore the recommended dose and…
- Trial name
- NCT04424251
- Testing
- Experimental: stage I：HSK21542 0.4 μg/kg, Experimental: stage I：HSK21542 1 μg/kg, Experimental: stage I：HSK21542 0.5μg/kg
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Pain
A Study of the Recovery Benefits After Treatment With Parecoxib/Valdecoxib in Patients Undergoing Abdominal Surgery
The purpose of this study is to evaluate morphine intake in the first 4 hours after abdominal surgery. Morphine intake is compared between patients on placebo and patients on parecoxib/valdecoxib.
- Trial name
- NCT00651300
- Testing
- Parecoxib/Valdecoxib
- Where
- 8 sites in Australia
- Volunteers
- 91 people
- Sponsor
- Pfizer
Radiation Dermatitis
StrataXRT Versus Aquaphor for the Prevention and Management of Radiation Dermatitis
The aim of this study is to assess the efficacy and safety of StrataXRT® in comparison to standard of care (defined using the Common Terminology Criteria for Adverse Events [CTCAE], version 5.0) by assessing the severity of…
- Trial name
- NCT05553392
- Testing
- StrataXRT, Aquaphor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stratpharma AG
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia with tracheal intubation. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07252921
- Testing
- HRS-9190
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Induction and Maintenance of General Anesthesia
A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients
This is a multi-center, randomized, open-label, positive-controlled (propofol) phase II clinical trial. The study plans to enroll approximately 46 eligible subjects.
- Trial name
- NCT04048811
- Testing
- HSK3486, Propofol, Propofol HSK3486
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy of the 220 mg dose Pradaxa to generate additional data in predefined sub populations of patients at increased risk of bleeding or VTE
- Trial name
- NCT00846807
- Where
- 112 sites in Austria, France and 7 more
- Volunteers
- 5,476 people
- Sponsor
- Boehringer Ingelheim
Thrombocytopenia Associated With Liver Disease
Treatment of Thrombocytopenia in Patients With Chronic Liver DiseaseUndergoing an Elective Procedure
This is a global, multicenter, randomized, double-blind, placebo-controlled, parallel group study using avatrombopag to treat adults with thrombocytopenia associated with liver disease.
- Trial name
- NCT01972529
- Testing
- avatrombopag (lower baseline platelet count), avatrombopag (higher baseline platelet count)
- Where
- 109 sites in United States, Argentina and 18 more
- Volunteers
- 231 people
- Sponsor
- Eisai Inc.
Infertility
Diafert® for Embryo Selection and Fertility Improvement
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02593461)
- Testing
- Daifert, Control Group
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Forest Laboratories
Cardiac Surgery Associated - Acute Kidney Injury
Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury Following Elective Cardiac Surgery
The is a two-stage study. Stage 1 is to evaluate the safety, tolerability, PK and PD of ENN0403 in patients at high risk of AKI following elective cardiac surgery requring cardiopulmonary bypass.
- Trial name
- NCT06632613
- Testing
- ENN0403 capsules, low dose, ENN0403 capsules, high dose
- Where
- China
- Volunteers
- 200 people
- Sponsor
- EnnovaBio
Anesthesia, Intravenous
Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery
A phase III confirmatory trial evaluating the efficacy and safety of remimazolam (CNS7056) compared to propofol for intravenous anesthesia during elective surgery in ASA Class III/IV patients.
- Trial name
- NCT03661489
- Testing
- Remimazolam, Propofol
- Where
- Germany
- Volunteers
- 469 people
- Sponsor
- Paion UK Ltd.
Hemophilia
Safety and Efficacy of FVIIa to Prevent Excessive Bleeding in Hemophilia Patients With Inhibitors Undergoing Major Surgery
This is an interventional, prospective, international, multicenter, single-arm, Phase 3, and sequential efficacy and safety study in adolescents and adults with congenital hemophilia A or B with inhibitors to factor VIII (FVIII)…
- Trial name
- SCOPE HIM (NCT05695391)
- Testing
- Coagulation Factor VIIa (Recombinant)
- Where
- 15 sites in United States, Malaysia and 4 more
- Volunteers
- 2 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies