Clinical trials: Elective Surgeries
Postoperative Recovery, Length of Hospital Stay
The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery
Anticholinergic drugs are common in older adults and linked to cognitive decline, frailty, longer hospital stay, and higher mortality.
- Conditions
- Postoperative Recovery, Length of Hospital Stay, Postoperative Complications
- Trial name
- NCT06349057
- Testing
- reducing anticholinergic burden
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus
Effects of Evolocumab on Platelet Reactivity in Patients With Diabetes Mellitus
Prospective, single center, double-blind, randomized pharmacodynamic experimental study. The study will enroll 150 subjects with ASCVD on optimal statin therapy as per physician and Diabetes Mellitus (DM) undergoing elective…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- ISS-DMII (NCT03258281)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Inova Health Care Services
Knee Injuries and Disorders, Hip Injuries and Disorders
Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery
The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after…
- Conditions
- Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
- Trial name
- OpiateLEO (NCT02997644)
- Testing
- Video Education, Usual Care Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Colorectal Cancer, Insulin Resistance
Prehabilitation Versus Enhanced Recovery Program for Elective Colorectal Cancer Surgery.
Elective surgery is the most effective treatment option for colorectal cancer, however it has been recognized to be associated with high morbidity and mortality risks.
- Trial name
- PrehabVsERAS (NCT03758209)
- Testing
- Prehabilitation + ERAS, ERAS
- Where
- Hungary
- Volunteers
- 184 people
- Sponsor
- St. Borbala Hospital
Diabetes Mellitus, Type 2, Coronary Artery Disease
Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI
To date there is very little PD and pharmacokinetic (PK) data on the ticagrelor 60 mg bid dosing regimen. In particular, there is no prospective PK/PD study on this dosing regimen in patients with DM who are known to have…
- Trial name
- OPTIMUS-6 (NCT03437044)
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Caesarean Section
Sensitivity of Hyomental Distance Ratio as a Single Predictor of Difficult Intubation in Obstetrics
This is a study to detect the sensitivity of thyromental distance ratio as a single predictor for difficult intubation in patients undergoing cesarean section under general anesthesia.
- Trial name
- HMDR (NCT00916812)
- Where
- United Arab Emirates
- Volunteers
- 188 people
- Sponsor
- King Khaled Eye Specialist Hospital
Angina Pectoris, Unstable Angina
Pilot Study of Hemoglobin Based Oxygen Therapeutics in Elective Coronary Revascularization
The purpose of this study is to assess the safety and feasibility of a novel oxygen carrying solution, HBOC-201, in the setting of PCI for Acute Coronary Syndromes from randomization til hospital discharge.
- Conditions
- Angina Pectoris, Unstable Angina, Myocardial Infarction
- Trial name
- NCT00317512
- Testing
- Percutaneous Coronary Revascularization, Hemoglobin-Based Oxygen Carrier-201 (HBOC-201), Voluven
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 45 people
- Sponsor
- Biopure Corporation
Atelectasis, Mechanical Ventilation
Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography
During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis…
- Conditions
- Atelectasis, Mechanical Ventilation, General Anesthesia, Prone Position
- Trial name
- NCT07325812
- Testing
- Alveolar Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Postoperative Urinary Retention, Total Hip Arthroplasty
RCT Foley Catheter Study for Elective TJA
Urinary retention is a known complication following surgical procedures, with a theoretical increased risk in patients receiving neuraxial anesthesia due to a decreased ability to sense bladder distension.
- Conditions
- Postoperative Urinary Retention, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- NCT05428020
- Testing
- Indwelling foley catheter, No foley catheter
- Where
- United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Elective Circumcision Surgery
A Comparison of the Efficacy of Sacral Erector Spinae Plane Block and Penile Block in Circumcision Surgery
Effective perioperative analgesia is crucial for reducing hospital stay in pediatric surgical patients. Opioid-based analgesia, although effective, may lead to respiratory depression in the postoperative period.
- Trial name
- SACRAL ESP (NCT07097844)
- Testing
- 0.8 mL/kg of 0.25% bupivacaine
- Volunteers
- 62 people
- Sponsor
- Siirt Training and Research Hospital
Hepatocellular Carcinoma
Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors
This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary Hepatocellular carcinoma.
- Trial name
- NCT05331911
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Elective Surgeries
Postoperative Quality of Recovery in Patients Receiving Anaesthesia
The investigator's study is designed to evaluate the recovery of patients receiving anaesthesia for surgeries; in different domains like the physiological, nociceptive, cognitive and emotional to the participants' preoperative…
- Trial name
- NCT03535025
- Where
- Nepal
- Volunteers
- 195 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Head and Neck Cancer Squamous Cell Carcinoma
Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer
This is a non-comparative randomized Phase 2 study using the INITIUM regimen with or without elective nodal irradiation (ENI) delivered before surgery for resectable head and neck squamous cell carcinoma (HNSCC).
- Trial name
- INITIUM (NCT07773987)
- Testing
- Pembrolizumab, Radiotherapy, ENI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Elective Major Abdominal Surgery
PostoperAtive Neurocognitive Dysfunction After Major AbdomiNal Surgery (PANDAMAN)
Predisposing and precipitating factors for perioperative delirium for the elderly remain elusive. This research will be conducted to determine risk factors of postoperative delirium.
- Trial name
- PANDAMAN (NCT06182215)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Surgery, Thoracic
Comparing Erector Spinae Plane (ESP) and Thoracic Paravertebral (TPV) Block Analgesic Effect After Elective VATS
The aim of the study is to compare two different locoregional techniques in VATS.
- Trial name
- NCT05798585
- Testing
- ESP block
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Andrea Saporito
Blood Transfusion
Perioperative Transfusion Related Outcome
A secondary analysis of the Turkish National Perioperative Transfusion Study (TULIP TS) database will be performed.
- Trial name
- NCT03930355
- Testing
- Blood transfusion, Control
- Where
- 60 sites in Turkey (Türkiye)
- Volunteers
- 6,121 people
- Sponsor
- Diskapi Teaching and Research Hospital
Video Laryngoscope, Double Lumen Tube Intubation
C-MAC Blade D Video Vs Macintosh Laryngoscope for Double Lumen Tube Insertion
The goal of this clinical trial is to know which type of laryngoscope is better for Double Lumen Tube (DLT) insertion, in participants undergoing elective thoracic surgeries.
- Conditions
- Video Laryngoscope, Double Lumen Tube Intubation, Elective Thoracic Surgery
- Trial name
- DLT (NCT06759038)
- Testing
- C-MAC blade D video laryngoscope, Macintosh Laryngoscope
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Colorectal (Colon or Rectal) Cancer
An Observational Cohort Study to Assess the Postop Activity of Colorectal Patients Undergoing Elective Surgery (PHYSPAL)
All participants will have a physical activity monitor placed onto the right thigh in the midline which will start collecting data at midnight on the first postoperative day.
- Trial name
- PHYSPAL (NCT05934643)
- Testing
- ActivPAL accelerometer, Hospital Anxiety and Depression Scale (HADS) Questionnaire
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Nottingham
Hemorrhage Postpartum
Sublingual Misoprostol to Reduce Blood Loss During Elective Cesarean Delivery
Sublingual Misoprostol to Reduce Blood Loss During Elective Cesarean Delivery : A Randomized Controlled Trial
- Trial name
- NCT03140033
- Testing
- Misoprostol Oral Tablet, Ranitidine Oral Tablet
- Where
- Egypt
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Surgical Bleeding
Evaluation of Safety of HEMOBLAST Bellows in Spine Surgery
The purpose of this clinical investigation in open, elective, spine surgery is to collect data to support the removal of the neurosurgical exclusion from the currently approved indication for the use of HEMOBLAST™ Bellows.
- Trial name
- NCT04734535
- Testing
- HEMOBLAST™ Bellows, absorbable gelatin sponge with thrombin
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Dilon Technologies Inc.
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