Clinical trials: Elective Surgical Patients
Prophylaxis, Thromboembolism, Venous, Total Knee Replacement
Study to Observe Safety of Xarelto in VTE Prophlylaxis After Elective TKR (Total Knee Replacement) or THR (Total Hip Replacement)
The primary objective of this study is to evaluate the safety of Xarelto in the prophylaxis of VTE in Indian patients undergoing elective TKR/THR
- Conditions
- Prophylaxis, Thromboembolism, Venous, Total Knee Replacement, Total Hip Replacement
- Trial name
- XYRIS (NCT01523418)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Sponsor
- Bayer
Aortic Valve Stenosis
Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry
Multicenter registry data analysis of aortic valve stenosis patients that underwent elective, isolated transcutaneous aortic valve implantation (TAVI) or surgical aortic valve replacement between 2015 and 2019.
- Trial name
- AVALON (NCT05308173)
- Testing
- Surgical Aortic Valve Replacement, Transcutenous Aortic Valve Implantation
- Volunteers
- 2,393 people
- Sponsor
- Nicolaus Copernicus University
Acute Respiratory Distress Syndrome
Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient
We propose that as low tidal volume ventilation has proven to be beneficial in patients with established ARDS it may have a role in preventing the onset of acute lung injury in the cardiac surgical population.
- Trial name
- NCT00538161
- Testing
- Ventilation strategy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Beth Israel Deaconess Medical Center
Fluid Management During Elective Spine Surgeries
Conventional Fluid Management vs Plethysmographic Variability Index -Based Goal Directed Fluid Management
Plethysmographic variability index is a dynamic method for evaluation of volume status which depends on estimation of respiratory variations in pulse oximeter waveform amplitude.
- Trial name
- NCT05239286
- Testing
- General anaesthesia, Conventional fluid managment, PVI dependant goal directed fluid therapy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Mental Impairment, Complication
Impact and Burden of Postponing Elective Surgeries
Overall, little is known about the effects and burdens of postponed operations in patients with urological diseases. To investigate the consequences and develop possible strategies for overcoming these challenges, the…
- Trial name
- NCT06067373
- Testing
- questionnaire
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Graz
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Complications; Arthroplasty, Mechanical
DePuy Revision TKA Implant 5yr Survivorship
This will be a retrospective chart review of 200 charts of adult patients who have undergone a revision TKA at New England Baptist Hospital and who received implant component(s) manufactured by DePuy Orthopedics.
- Trial name
- NCT01245478
- Sponsor
- The New England Baptist Hospital
Knee Injuries and Disorders, Hip Injuries and Disorders
Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery
The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after…
- Conditions
- Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
- Trial name
- OpiateLEO (NCT02997644)
- Testing
- Video Education, Usual Care Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Postoperative Recovery, Anesthesia, General
Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery
This randomized controlled trial evaluates postoperative quality of recovery assessed with the Quality of Recovery-15 questionnaire in adult patients undergoing elective major urological surgery under opioid-free versus…
- Conditions
- Postoperative Recovery, Anesthesia, General, Analgesics, Opioid, Urologic Surgical Procedure
- Trial name
- QoR-OFA-URO (NCT07665463)
- Testing
- Remifentanil-based general anesthesia, Opioid-free general anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Anticoagulants and Bleeding Disorders, Surgery
Residual Anti-Xa Activity After Last Treatment Dose of Enoxaparin
The main objective of this study is to determine the time interval following the last treatment dose of enoxaparin at which the amount of anti-Xa level activity is reliably less than 0.2 international unit per milliliter (IU/mL)…
- Conditions
- Anticoagulants and Bleeding Disorders, Surgery, Regional Anesthesia Morbidity
- Trial name
- NCT03296033
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Wake Forest University Health Sciences
Elective Surgical Procedure
Perioperative Management & Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients
In August 2022 the European Society of Cardiology published updated guidelines including recommendations on preoperative transthoracic echocardiography.
- Trial name
- NCT06409234
- Testing
- Transthoracic Echocardiography Recieved
- Where
- Germany
- Volunteers
- 8,250 people
- Sponsor
- European Society of Anaesthesiology
Intra-abdominal Surgery
Stem Cells Found in the Abdominal Cavity in Humans
The purpose of this research study is to determine the genotype (genetic composition) and phenotype (physical appearance) of cells derived from the abdominal cavity to determine whether stem cells are present.
- Trial name
- NCT00576264
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cedars-Sinai Medical Center
Thrombocytopenia
Lusutrombopag Combined With Recombinant Human Thrombopoietin for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Destined to Undergo Elective Invasive Surgery
To assess the efficacy and safety of lusutrombopag combined with recombinant human thrombopoietin for the treatment of thrombocytopenia in patients with chronic liver disease destined to undergo elective invasive surgery.
- Trial name
- NCT06673498
- Testing
- Lusutrombopag combined with recombinant human thrombopoietin
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Anhui Provincial Hospital
Tumors, Primary Neoplasm
Perioperative Risk Study
The primary objective of this trial is to determine if perioperative risk stratification and risk-based, protocol-driven management leads to a reduction in the rate of death or serious complications compared to standard…
- Conditions
- Tumors, Primary Neoplasm, Secondary Neoplasm, Surgery
- Trial name
- PRS (NCT02456389)
- Testing
- Preoperative risk stratification, Postoperative risk stratification, Risk-based, escalating levels of care
- Where
- United States
- Volunteers
- 1,456 people
- Sponsor
- Fox Chase Cancer Center
Dyspnea, Pulmonary Edema
The Incidence of TRALI in Patients Undergoing Orthopedic-Oncology Surgery
Currently Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality in the United States, and one of major post-transfusion complications.
- Trial name
- NCT00914784
- Where
- Israel
- Volunteers
- 550 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Surgery
The Clinical Efficacy of Supraglottic Airway Device, Self-pressurized Air-Q Intubating Laryngeal Airway (ILA -SP) in Adult Patients: Comparison With Classic-laryngeal Airway (c-LMA)
Supraglottic airway devices (SADs) are well established in anesthetic practice. Among these devices ,classic laryngeal airway has been typically widely used.
- Trial name
- NCT02206438
- Testing
- Insertion of C-LMA, Insertion of air-Q according
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Venous Thromboembolism
Verification of XAPPORT: a Decision Support App for Physicians Used for Patients Anticoagulated With Rivaroxaban in Terms of Anticoagulation Management in Elective Surgery: Verification Process of Medical Decision Algorithm
This study shall determine whether XAPPORT - a mobile device app based on different guidelines, the summary of product characteristics of rivaroxaban, and clinical facts and practice - provides adequate guidance to physicians…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Pulmonary Embolism
- Trial name
- VeriXAPPORT (NCT02900404)
- Testing
- XAPPORT, Expert Panel ("gold standard")
- Sponsor
- Bayer
General Anesthesia
Effect of Tegoprazan for Elective Surgery Patients Under General Anesthesia
The aim of this study is to compare gastric pH right after endotracheal intubation for general anesthesia in patients pretreated with tegoprazan, famotidine, or placebo.
- Trial name
- NCT06743243
- Testing
- Tegoprazan, Famotidine
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Seok Kyeong Oh
Acute Pain, Surgery
Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain:
This is a research project in which two standard of care practices will be evaluated to examine the difference in outcomes. The goal is to improve patient care and safety.
- Trial name
- PROTECT (NCT05370404)
- Testing
- Prescription by surgical team, Recommendation by surgical team
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Hyperlactatemia, Brain Tumor
Hyperlactatemia During and After Tumorcraniotomy
This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy.
- Conditions
- Hyperlactatemia, Brain Tumor, Surgery, Anesthesia
- Trial name
- NCT04410315
- Testing
- Serum-lactate < 2,2 mmol/L, Serum-lactate >/= 2,2 mmol/L
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet