Clinical trials: Elective Surgical Patients
Neuromuscular Blockade, Postoperative Complications
Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients.
- Trial name
- NCT02635542
- Testing
- Succinylcholine, Cisatracurium
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Surgery
The Clinical Efficacy of Supraglottic Airway Device, Self-pressurized Air-Q Intubating Laryngeal Airway (ILA -SP) in Adult Patients: Comparison With Classic-laryngeal Airway (c-LMA)
Supraglottic airway devices (SADs) are well established in anesthetic practice. Among these devices ,classic laryngeal airway has been typically widely used.
- Trial name
- NCT02206438
- Testing
- Insertion of C-LMA, Insertion of air-Q according
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Mechanical Ventilation, Lung Protective Ventilation
Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries
Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient.
- Conditions
- Mechanical Ventilation, Lung Protective Ventilation, Driving Pressure
- Trial name
- NCT07092943
- Testing
- Lung protective ventilation, Driving pressure guided ventilation
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Postoperative Delirium, Aging Disorder
Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams
In the world, 230 million surgeries are performed every year and US data indicates that more than a third of patients who undergo surgery are older than 65 years, in which between 10 and 70% develop postoperative delirium (POD).
- Trial name
- PREPODOT (NCT03704090)
- Testing
- Occupational therapy intervention, Standard non-pharmacological prevention intervention
- Where
- Chile
- Volunteers
- 160 people
- Sponsor
- University of Chile
Preoperative, Carbohydrate
Preoperative Two Hours Carbohydrate Load On Pediatric Patient Undergoing Elective Surgery
This work evaluated the systemic effect of different preoperative carbohydrate (CHO) loads in pediatrics undergoing elective surgery.
- Conditions
- Preoperative, Carbohydrate, Pediatric, Elective Surgery
- Trial name
- NCT06833671
- Testing
- Apple juice, Anhydrous glucose, Water
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Surgery
Digital Prehabilitation for Patients Undergoing Major Elective Surgery
Prehabilitation describes the process of improving someone's functional capacity before major surgery. Prehabilitation commonly focuses on exercise training, as fitness level is a predictor of surgical outcomes - the fitter you…
- Trial name
- NCT06137781
- Testing
- Six weeks of digital prehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Anesthesia
A Study to Evaluate the Accuracy of aTCI Model of Cipepofol in Patients With General Anesthesia During Elective Surgery
This study is a multi-center (each center independently conducts the study according to the same research protocol), randomized, and open-label clinical study.
- Trial name
- NCT06740201
- Testing
- Cipepofol
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Congenital Bleeding Disorder, Haemophilia A With Inhibitors
A Long-term Assessment of Physical Activity, Range of Motion, and Functional Status Following Elective Orthopedic Surgery in Hemophilia Patients With Inhibitors
This study is conducted in the United States of America (USA). The aim of this study is to assess the long-term (5+ years) postoperative functional outcomes of elective orthopaedic surgery (EOS) patients from previously reported…
- Conditions
- Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
- Trial name
- NCT01830712
- Testing
- eptacog alfa (activated)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Novo Nordisk A/S
Pain, Postoperative, Pain, Acute
A Study of the Effects of Intravenous Magnesium Sulphate on Anaesthesia and Analgesia in Elective General Surgery Patients
The aim of this double-blind randomized study will be to evaluate the effect an intravenous infusion of magnesium has on recovery outcomes after elective laparoscopic cholecystectomy
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Nociceptive, Analgesia
- Trial name
- NCT05598307
- Testing
- magnesium bolus followed by normal saline infusion, magnesium bolus followed by magnesium infusion, normal saline bolus followed by normal saline infusion
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Aretaieion University Hospital
Diabetes Mellitus Type 2
Carbohydrate Loading in Type 2 Diabetes Mellitus
The goal of this clinical trial is to learn the effects of preoperative carbohydrate loading on perioperative blood glucose levels and insulin resistance in type 2 diabetes mellitus undergo elective surgery.
- Trial name
- NCT06687811
- Testing
- preoperative carbohydrate loading
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia
Inguinal Hernia, Acute Appendicitis
The Onset Time of Rocuronium in Emergency and Elective Surgery
Rocuronium, a nondepolarizing neuromuscular blocking agent, is used in general anesthesia to provide conditions for endotracheal intubating.
- Trial name
- NCT02634255
- Testing
- Rocuronium elective surgery, Rocuronium emergency surgery, Propofol
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Hypotension
Haemodynamic Response to General Anaesthesia in Healthy Orthopaedic Patients
Continuous cardiovascular monitoring as part of management of high-risk surgical patients is widely practiced, however its role in low-risk surgical patients is unclear.
- Trial name
- HRespToAS (NCT02834000)
- Testing
- LiDCO rapid™ CNAP monitoring
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Major Abdominal Surgery
Preoperative Measurement of Heart Rate Variability as a Predictor of Postoperative Outcome
The purpose of the study is to confirm the hypothesis that a dysfunction of the autonomic nervous system could complicate the postoperative course in the patient undergoing surgery.
- Trial name
- NCT02375412
- Testing
- Pre-operative measurement of heart rate variability
- Where
- Czechia
- Volunteers
- 65 people
- Sponsor
- University Hospital Ostrava
Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety
Effects of Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety for Patients Undergoing Elective Surgery
This study is a pilot randomized controlled trial (RCT) conducted at Tin Shui Wai Hospital to evaluate the effectiveness of a mobile-based mindfulness intervention in reducing preoperative anxiety among patients scheduled for…
- Conditions
- Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety, Postoperative Pain, Postoperative Use of Analgesics
- Trial name
- NCT07005973
- Testing
- mobile-based mindfulness intervention
- Where
- Hong Kong
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Surgery, Platelet Dysfunction
Low-dose Acetylsalicylic Acid Before Non-cardiac Surgery
This study aims to assess independent factors associated with the clinical decision to discontinue ASA preoperatively in patients undergoing elective non-cardiac surgery.
- Trial name
- NCT03049566
- Testing
- preoperative questionnaires
- Where
- Germany
- Volunteers
- 805 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Breast Neoplasm
Randomized Study of Elective Regional Lymph Node Irradiation in N1 Breast Cancer
This study evaluates the impact of elective regional lymph node irradiation on N1 breast cancer patients receiving post-lumpectomy radiotherapy and anthracycline plus taxane (AT)-based chemotherapy.
- Trial name
- NCT03269981
- Testing
- Whole breast irradiation, Whole breast and nodal irradiation
- Where
- South Korea
- Volunteers
- 827 people
- Sponsor
- Samsung Medical Center
Urologic Diseases, Cardiovascular Diseases
Patient Empowerment for Major Surgery Preparation @ Home
Non-randomized monocentric open cohort study vs historical comparative group testing the efficacy of a multimodal prehabilitation program (based on physical activity, nutritional support and mental preparation) for unfit patients…
- Conditions
- Urologic Diseases, Cardiovascular Diseases, Thoracic Diseases, Orthopedic Disorder
- Trial name
- Paprika (NCT04190719)
- Testing
- multimodal prehabilitation
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Atrial Fibrillation
Perioperative Anticoagulant Use for Surgery Evaluation Study
The aim of the Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study, is to establish a safe, standardized protocol for the perioperative management of patients with atrial fibrillation (AF) who are receiving a…
- Trial name
- PAUSE (NCT02228798)
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 3,135 people
- Sponsor
- McMaster University
Iron Deficiency Anemia
Polyglucoferron Compared to i.v. Ferric Carboxymaltose and Oral Iron Substitution in Preoperative Treatment of Iron Deficiency Anaemia in Patients
Patients with IDA and for whom fast replenishment of iron stores is necessary, e.g. if its not appropriated to postpone surgery, will be identified within 28 to 42 days before surgery.
- Trial name
- IDA-I (NCT04087993)
- Testing
- Polyglucoferron, Ferric carboxymaltose, Ferrous Sulfate
- Where
- Germany
- Sponsor
- Dr. Frank Behrens