Clinical trials: Electroconvulsive Therapy
Dementia
Safety and Efficacy of Electroconvulsive Therapy (ECT) for Behavioural and Psychological Symptoms of Dementia (BPSD)
This is a prospective, open-label, observational study of the efficacy and safety of ECT for BPSD. There is no control or comparison group.
- Trial name
- ECTBPSD (NCT02969499)
- Where
- 3 sites in Canada
- Volunteers
- 33 people
- Sponsor
- University of British Columbia
Physiatrics, Electroconvulsive Therapy
Does Repetitive Electroconvulsive Therapies Affect Propofol Induction Dose ?
Electroconvulsive therapy has been used for many years for different types of physiatric diseases. General anesthesia is used during the procedure. Different anesthesiologists use different regimens.
- Trial name
- NCT02394847
- Testing
- propofol
- Volunteers
- 10 people
- Sponsor
- Ankara University
Depressive Disorder
Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study
Depression is a major psychiatric illness associated with significant morbidity and mortality. Electroconvulsive therapy (ECT) is the most effective treatment for depression and arguably the safest.
- Trial name
- ECT+LITHIUM (NCT05923476)
- Testing
- Lithium
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Melbourne Health
Unipolar Depression
Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding
In treatment-resistant depression, electroconvulsive therapy (ECT) has been shown to effectively reduce depressive symptoms, though the underlying neurobiological mechanism is still unclear.
- Trial name
- NCT00922064
- Testing
- ECT
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Depression
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
This study will generate new information on how to optimise brain targets with ECT stimulation.
- Trial name
- NCT03297411
- Testing
- Brief Temporoparietal ECT, Ultrabrief Temporoparietal ECT, Brief Frontoparietal ECT
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- The University of New South Wales
Depression
Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression
This study will compare four types of electroconvulsive therapy to determine if they differ in their effects on mood, thinking, brain activity, and biochemistry in people with major depressive disorder.
- Trial name
- NCT00487500
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Mental Disorders
French Observatory of ElectroConvulsive Therapy (ECT)
Since the 30s, ECT has been a psychiatric treatment mainly used for drug-resistant depressive illnesses. Clinical studies have shown its therapeutic efficiency compared to standard treatments also in other psychiatric illnesses.
- Trial name
- NCT04477434
- Where
- 30 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Henri Laborit
Esketamine, ECT
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in…
- Conditions
- Esketamine, ECT, Depression, Adolescent
- Trial name
- NCT07247968
- Testing
- Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume)
- Where
- 2 sites in China
- Volunteers
- 220 people
- Sponsor
- Min Su
Depressive Disorder, Major, Bipolar Depression
Ketamine Versus Electroconvulsive Therapy in Depression
While there are effective treatments for depression available, some patients do not see results with these options. Often, these patients are referred to electroconvulsive therapy (ECT) which has drawbacks such as adverse side…
- Trial name
- NCT03674671
- Testing
- Intravenous Ketamine, Electroconvulsive Therapy
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
ECT, Anesthesia
Sevoflurane in Electroconvulsive Therapy
The purpose of the study was to investigate the effects of different doses of sevoflurane used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and recovery profiles
- Trial name
- NCT01905904
- Testing
- sevorane
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Inonu University
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Haemodynamic Rebound
The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy
The investigators will be evaluated the effects of a single loading dose of remifentanil (1µg/kg), administered as an adjunct to sevoflurane, on duration of hemodynamic profile, seizure activity, and recovery times during…
- Trial name
- NCT02271555
- Testing
- Sevoflurane, Remifentanil, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Inonu University
Major Depressive Disorder
Predictors of Treatment Outcome in Major Depressive Disorder
Major depressive disorder (MDD) is a common and disabling mental health condition characterized by persistent low mood, loss of interest, and disruptions in sleep, appetite, and daily functioning.
- Trial name
- NCT07853365
- Volunteers
- 100 people
- Sponsor
- Assiut University
Depressive Episode, Electroconvulsive Therapy
Electroconvulsive Treatment Followed by Cognitive Control Training
Major depressive disorder (MDD) is worldwide one of the most prevalent and disabling mental health conditions. Electroconvulsive therapy (ECT) is a safe and effective treatment even though 6-month relapse rates are high.
- Conditions
- Depressive Episode, Electroconvulsive Therapy, Cognitive Remediation
- Trial name
- ECT-CCT (NCT04383509)
- Testing
- Cognitive Control Training, Active Control
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Ghent
Education, Medical, Undergraduate, Electroconvulsive Therapy
Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therapy Training: A Non-Inferiority Study
The goal of this prospective, open-label non-inferiority randomized controlled trial is to investigate if Virtual Reality (VR) based simulation are an effective training tool for novice medical trainees.
- Conditions
- Education, Medical, Undergraduate, Electroconvulsive Therapy, Virtual Reality Simulation
- Trial name
- ECT-SIM (NCT07350278)
- Testing
- Virtual Reality electroconvulsive therapy simulator, Mannequin Simulator
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depression
The Effect on Cognition of Terminating ECT Induced Seizures With Propofol
Participating subjects are those who are referred for electroconvulsive therapy (ECT) for severe depression who have agreed to the protocol. The control group receives ECT as usual.
- Trial name
- NCT00616759
- Testing
- electroconvulsive therapy, electroconvulsive therapy plus propofol, propofol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Loma Linda University
Major Depressive Disorder, Suicide
Accelerated iTBS for Depression and Suicidality
The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive…
- Trial name
- RAPID (NCT04441008)
- Testing
- Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT)
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Schizophrenia
Electroconvulsive Therapy in Clozapine Refractory Schizophrenia
This study will evaluate electroconvulsive therapy (ECT) in patients who have not responded adequately to clozapine.
- Trial name
- NCT00042224
- Testing
- Electroconvulsive Therapy (ECT), Clozapine
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Northwell Health
Intracranial Pressure Change, Hypertension
Optic Nerve Sheath Ultrasound During Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is an effective method that has been used for many years in the treatment of psychiatric disorders and is currently administered under general anesthesia.
- Conditions
- Intracranial Pressure Change, Hypertension, Electroconvulsive Therapy Treated Patients
- Trial name
- NCT06607679
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- İrem AKSOY
Major Depressive Disorder
Multimodal Imaging of ECT Effects
The project aims to investigate markers of neural activity and connectivity, neurochemistry, hypothalamic-pituitary-adrenal (HPA) axis activity, inflammation and neuronal plasticity underlying treatment response and remission…
- Trial name
- NCT02871141
- Testing
- electroconvulsive therapy, Antidepressant
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Charite University, Berlin, Germany