Clinical trials: Electrodes, Implanted
HTN-Hypertension, Blood Pressure Management
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies.
- Trial name
- NCT06969846
- Testing
- CSN electrode was implanted around tissue including CSN branches
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Hearing Loss, Bilateral Sensorineural, Hearing Loss, Sensorineural
Performance and Hearing-related Outcomes in Adults Implanted With the CI622D Dexamethasone-eluting Cochlear Implant Compared to Those Implanted With a Standard Cochlear Implant (CI622)
This clinical study will test a newly developed cochlear implant known as CI622D. This experimental cochlear implant has been designed to slowly release a drug called dexamethasone.
- Conditions
- Hearing Loss, Bilateral Sensorineural, Hearing Loss, Sensorineural, Hearing Loss, Bilateral, Hearing Loss, Cochlear
- Trial name
- DETECT (NCT06424262)
- Testing
- CI622D, CI622
- Where
- 11 sites in Australia, France and 2 more
- Volunteers
- 50 people
- Sponsor
- Cochlear
Bradycardia, Congestive Heart Failure
The EASYTRAK EPI Clinical Investigation
The purpose of this study is to assess the safety and effectiveness of the EASYTRAK EPI lead.
- Trial name
- EASYTRAK EPI (NCT00158925)
- Testing
- EASYTRAK EPI lead
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease, Essential Tremor
Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- LFP DBS (NCT02071446)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Cochlear Implant
CT Scalar Localization
Comparing the location of cochlear implants to level of retained hearing.
- Trial name
- NCT04430140
- Testing
- CT Scan
- Sponsor
- Mayo Clinic
Cochlear Implants, Hearing Loss, Sensorineural
Clinical Trial to Compare Two Surgical Approaches to the Cochlea
This is a prospective multicenter multinational randomized control trial. The duration of the study for the individual patient will be approximately 1 year (pre-operative assessments, 1 week, 3 months and 12 months follow-up…
- Trial name
- BULLS-I (NCT06453343)
- Testing
- Surgical approach: cochleostomy or extended round window
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Focal Epilepsy, Electrodes, Implanted
Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients
The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
- Conditions
- Focal Epilepsy, Electrodes, Implanted, Cognitive Function, Neurophysiology
- Trial name
- EpiMicro (NCT04653012)
- Testing
- Intracranial macro-microelectrode recording
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hearing Loss, Partial Deafness
Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults With Partial Deafness
The purpose of this feasibility study is to evaluate whether low-frequency acoustic hearing sensitivity can be preserved in newly implanted adults with partial deafness (considerable low frequency acoustic hearing profiles with…
- Conditions
- Hearing Loss, Partial Deafness, Hearing Disorders, Ear Diseases
- Trial name
- NCT02189798
- Testing
- HiRes 90K™ Advantage implant with HiFocus™ Mid-Scala electrode, EAS sound processor
- Where
- 11 sites in United States
- Volunteers
- 67 people
- Sponsor
- Advanced Bionics
Phantom Limb
Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Individuals with upper-limb amputation usually have intact nerves within the residual limb, and studies have demonstrated that electrical stimulation of those nerves can produce sensations that appear to emanate from the…
- Trial name
- PhantomLimb (NCT02684201)
- Testing
- Boston Scientific Stimulator Lead
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lee Fisher, PhD
Cochlear Implants
Objective Measures of Cochlear Implant Electrode Position and Function
Recruit adult patients eligible for cochlear Implant surgery. During routine surgery monitor electrode placement with new 'SCINSEV' technique and complete 'PECAPs' on patient to identify if any of the electrodes have misplaced.
- Trial name
- NCT04987684
- Testing
- SCINSEV and PECAP
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sophie McKenny
Epilepsy
Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy
This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy…
- Trial name
- NCT04788628
- Testing
- Baseline, Motor procedural memory task, Motor procedural memory task plus auditory stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Sensorineural Hearing Loss, Fibrosis
Evaluation of Electrode-modiolus Distance and Cochlear Fibrosis Using Depth Sounding and Spectroscopy Tools
Cochlear fibrosis development can compromise the success and the outcomes of the cochlear implantation (CI) thus affecting the quality of life of the implanted patient.
- Trial name
- TIMAGING (NCT05402969)
- Testing
- Transimedance Matrix measurements, Depth sounding and spectroscopy, Cone Beam Computer Tomography
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Montpellier
Hearing Loss
Scalar Localization Cochlear Electrode Array Using 64 Slice CT
Insertion of electrode array in scala vestibuli, rather than the preferred location within scala tympani, leads to loss of native hearing in those patients with isolated high-frequency hearing loss undergoing cochlear…
- Trial name
- NCT00587262
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Deafness With a Cochlear Implant
Stimulating the Cochlear Apex Without Longer Electrodes
The most common cochlear implant intervention provides an electrode array that stimulates less than half of the length of the cochlea, leaving the regions which represent lower frequencies in the normally functioning ear…
- Trial name
- NCT06901674
- Testing
- Modified surgical approach, Cochlear Nucleus CI632 cochlear implant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Cognition
A Study of the Higher Cognitive Functions of the Human Brain With Single-neuron Activity Recording
This study aims to investigate that neural activity of higher cognitve function of human brain with hyperflexible neural electrode-cortex
- Trial name
- NCT06408415
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Post Procedural Infection, Pacemaker Electrode Infection
Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study
This study is a multi-center open-label randomized study, and we sought to investigate the redundancy of post-procedural prophylactic antibiotics in cardiac implantable electronic device implantation.
- Conditions
- Post Procedural Infection, Pacemaker Electrode Infection, Antibiotics, Implantable Defibrillator User
- Trial name
- ABxFREE (NCT04146883)
- Testing
- Antibiotics
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Cheng-Kung University Hospital
Cochlear Implants
Longitudinal Outcomes in MED-EL Cochlear Implant Recipients Using a FLEX Electrode
This retrospective study aims at analysing data from clinical routine as anonymized data sets. The study aims at analysing clinical data from MED-EL Cochlear Implant (CI) recipients using a FLEX electrode array.
- Trial name
- LOTOS (NCT06343571)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Hearing Loss
Multi-center Study to Examine Changes to the Environment Surrounding the Electrodes in the Cochlea and to Capture the Most Challenging Listening Environments Experienced by Persons With a Cochlear Implant
This early feasibility study aims to collect pilot data on impedance measurements in real-world environments and to collect real-world and difficult listening situations and the factors impacting this, reflecting situations the…
- Trial name
- DICE (NCT06173687)
- Testing
- The impedance measurement task using the Mobile Research App (MRA)
- Where
- 4 sites in Australia, Belgium and 1 more
- Volunteers
- 51 people
- Sponsor
- Cochlear
Amputations, Peripheral Nerve Injury
Micro-Electrodes Implanted in a Human Nerve
The main objective of the intervention in the study is devise feasibility using high-count microelectrode arrays implanted into peripheral nerves of patients with limb amputations or peripheral nerve injury.
- Conditions
- Amputations, Peripheral Nerve Injury, Spinal Cord Injury
- Trial name
- NCT02034461
- Testing
- Utah Slanted Electrode Array
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Utah
Heart Failure, Ventricular Dysfunction
Safety and Performance of Electrodes Implanted in the Left Ventricle
The study is intended to demonstrate the safe implant of small receiver-electrodes into the endocardial surface of the left ventricle and to demonstrate its utility in providing cardiac resynchronization therapy in heart failure…
- Conditions
- Heart Failure, Ventricular Dysfunction, Cardiomyopathies, Heart Diseases
- Trial name
- SELECT-LV (NCT01905670)
- Testing
- WiCS-LV system
- Where
- 2 sites in Czechia, Denmark
- Volunteers
- 39 people
- Sponsor
- EBR Systems, Inc.