Clinical trials: Elevated Blood Sugar
Postprandial Hyperglycemia
Bread Structure and Postprandial Metabolic Responses
The structural properties of bread are considered one of the most important factors that can affect its digestibility, glucose homeostasis and postprandial metabolic responses.
- Trial name
- NCT05691686
- Testing
- Finely milled whole wheat-legume bread, Less processed whole wheat-legume bread, Less processed whole wheat bread
- Where
- Greece
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Diabetes, Environmental Enteropathy
Enteropathy and Diabetes in HIV Patients
Emerging data suggest that HIV-infected people have disproportionately higher risk of diabetes than HIV-uninfected people. Multiple factors may contribute to elevated diabetes risk including increased prevalence of conventional…
- Conditions
- Diabetes, Environmental Enteropathy, HIV
- Trial name
- REEHAD (NCT03713502)
- Where
- Tanzania
- Volunteers
- 1,947 people
- Sponsor
- National Institute for Medical Research, Tanzania
Pre-diabetes, Impaired Fasting Glucose
Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy
The investigators hypothesize that sitagliptin will significantly reduce impairments in insulin secretion and insulin resistance resulting from short-term oral glucocorticoid therapy.
- Conditions
- Pre-diabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT01488279
- Testing
- Dexamethasone 2.5 mg and Sitagliptin 100 mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Type 1 Diabetes Mellitis, Cognition
Glycemic Control, Brain Structure and Cognition in Youth With Type 1 Diabetes (T1DM)
LO5 study: The investigators are inviting a new group of youth (ages 7-16) who have been recently diagnosed with type 1 diabetes and their non-diabetic siblings.
- Trial name
- LO5/HY5 (NCT00879203)
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pre Diabetes, Diabetes
Metabolic Response Evaluation of Low-sugar Snack Bars
To determine the post-prandial metabolic response and biomarker response, following the consumption of newly developed low glycaemic index (GI) snack bars.
- Conditions
- Pre Diabetes, Diabetes, Obesity
- Trial name
- NCT04653220
- Testing
- Control 1, Control 2, Standard Crokao
- Where
- Singapore
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Heart Failure
Heart & Diabetes - Feasibility Study
The main purpose of this study is to validate an intensive protocol of insulin infusion and subsequent subcutaneous insulin administration with the support of continuous glucose monitoring, in addition to reference finger-stick…
- Trial name
- NCT00922402
- Testing
- Intensive insulin infusion
- Where
- 2 sites in Italy
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Diabetes, Hypoglycemia
Investigating the Relationship Between Nocturnal Glucose Levels and Motion During Sleep
In this study the investigators will explore whether the motion during sleep of people with diabetes changes as a function of the blood glucose levels.
- Conditions
- Diabetes, Hypoglycemia, Hyperglycemia
- Trial name
- Moonwalk (NCT05609175)
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Bern
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type II Diabetes Mellitus
Feasibility Trial in Urban Pakistan for Community Engagement in Preventing Type II Diabetes and Risk Factors
This project aims to adapt, implement, and evaluate PLA based intervention in urban Karachi, Pakistan for TIIDM prevention and control.
- Trial name
- EMPOWER-D (NCT06570057)
- Testing
- Participatory, learning and Action (PLA) Based intervention
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baqai Institute of Diabetology and Endocrinology
Hyperglycaemia, Hypoglycaemia
Continuous Glucose Monitoring by Subcutaneous Measurement Compared to Frequent Point of Care Measurement by Accu Chek in Critically Ill Patients
The purpose of this study is to evaluate the accuracy and reliability of the continuous glucose monitoring system the FreeStyle Navigator® (Abbott, Diabetes Care) in critically ill patients by comparing subcutaneous measuring…
- Trial name
- RESCUEII (NCT01526044)
- Testing
- Freestyle Navigator
- Where
- Netherlands
- Volunteers
- 178 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Effects of Exenatide on Postprandial Hyperlipidemia and Inflammation
The primary goal of this study is to determine the acute effects of exenatide on postprandial hypertriglyceridemia. Secondary goals are to determine whether there are additional improvements in postprandial lipids and…
- Trial name
- NCT00974272
- Testing
- Exenatide, Normal Saline
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Carl T. Hayden VA Medical Center
Postprandial Hyperglycemia
Determination of the GI and II Values of Soft Drink and Soft Drink With Sugardown™
This study was a partly controlled laboratory-based study comparing the glycemic and insulinemic indices of 3 test meals containing soft drink alone or with SUGARDOWN™ (Galactomannan) in overweight adults.
- Trial name
- NCT03374501
- Testing
- Sugardown™, Soft drink
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston Therapeutics
Diabetes Mellitus, Type 2, Obesity
Egg Consumption and Glycemic Control in Individuals With Pre- and Type II-diabetes
The intent of this study is to examine the extent to which daily incorporation of egg into a diet improves glycemic control, insulin sensitivity, lipid profiles, and body composition in overweight and obese adults with pre- and…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Pre Diabetes
- Trial name
- NCT03272074
- Testing
- Egg and egg white
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Florida State University
High Risk Acute Lymphoblastic Leukemia
HCL Single Arm Pilot Study in Treatment of Hyperglycemia of Pediatric ALL
The overall objective of this pilot study is to determine the safety and feasibility of a hybrid closed-loop insulin delivery system for children and young adults with high risk acute lymphoblastic leukemia, during the induction…
- Trial name
- NCT05006040
- Testing
- Hybrid Closed Loop System
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Hyperglycemia, Covid19
Dipeptidyl Peptidase-4 Inhibitor (DPP4i) for the Control of Hyperglycemia in Patients With COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a world health issue during the last months, affecting mostly countries with a high metabolic risk, like Mexico.
- Trial name
- Covid19DPP4i (NCT04542213)
- Testing
- Linagliptin tablet, Insulin
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio
Diabetes Mellitus, Pre Diabetes
Glucose Tolerance and Prevention of Diabetes Mellitus Type 2 by Polyherbal Formulation
Primary protocol to this study is to develop a natural remedy to prevent diabetes mellitus in pre-diabetic state and elaborate the effectiveness of polyherbal formulation for carrying out Phase-II, III and IV.
- Trial name
- Phase-1 (NCT03884920)
- Testing
- Polyherbal formulation
- Where
- 2 sites in Pakistan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Islamia University of Bahawalpur
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