Clinical trials: Elevated Blood Sugar
Type 1 Diabetes
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms
Objective: to gain experience with in-home use of a modified algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is projected overnight and to obtain…
- Trial name
- PHM2 (NCT02438189)
- Testing
- Predictive Hyperglycemia Minimization Algorithm, Predictive Hypoglycemia Minimization Algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 33 people
- Sponsor
- Jaeb Center for Health Research
Elevated Blood Glucose
Effects of Zinc Supplementation on Patients With Elevated Glycemic Status
The goal of this randomized, double-blind, placebo-controlled study included patients with elevated glycemic status is to investigate whether zinc supplementation (4mg per day) has beneficial effects on controlling blood glucose.
- Trial name
- NCT06807996
- Testing
- Zinc-enriched yeast capsule
- Volunteers
- 124 people
- Sponsor
- Zhilei Shan
Type 2 Diabetes Mellitus, Hyperglycemia
Ex Vivo Immunotherapy for Hyperglycemia in Type 2 Diabetes Mellitus
Diabetes mellitus type 2 is a long-term metabolic disorder that is primarily characterized by insulin resistance, relative insulin deficiency and hyperglycemia.
- Trial name
- DISC (NCT02169531)
- Testing
- ex vivo Activated Immune Cells
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- B & Y Technologies
Type 1 Diabetes Mellitus, Hypoglycemia
FreeStyle Libre FGM During Summer Camp for Children With Type 1 Diabetes
A randomized, double-blinded, single center, parallel design pediatric study, on 45 subjects with type 1 diabetes (T1D), aged six to 15 (inclusive) years, measuring sensor time in glucose values within range 3.9 - 10 mmol/l (70 …
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hyperglycemia
- Trial name
- NCT03182842
- Testing
- FreeStyle Libre FGM, SMBG - Blinded Sensor
- Where
- Slovenia
- Volunteers
- 45 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Cardiovascular Diseases
One Year Mortality and Morbidity With Hyperglycemia Among Acute Cerebrovascular Accident Patients in Emergency Department: A Cohort Study
The "One Year Mortality and Morbidity Outcome with Hyperglycemia among Acute Cerebrovascular Accident Patients in Emergency Department" is an extensive prospective cohort study designed to look into how hyperglycemia affects the…
- Trial name
- NCT06560983
- Testing
- The investigators are planning to do a observational cohort study, hence won't be doing any intervention.
- Where
- 2 sites in Nepal
- Volunteers
- 46 people
- Sponsor
- Institute of medicine, Maharagjung medical campus
PreDiabetes, Impaired Glucose Tolerance
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
The primary objective is to examine the impact of the Renin-Angiotensin-Aldosterone System (RAAS) blockade with medications (valsartan) or RAAS and neprilysin inhibition (valsartan/sacubitril) vs.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Obesity, Blood Pressure
- Trial name
- NCT03938389
- Testing
- Sacubitril-Valsartan Tab 97-103 MG, Valsartan 160mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Diabetes, Hyperglycemia
Miniaturized Breath-based Sensor for the Detection of Hypo- and Hyperglycemia
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia (Diabetic)
- Trial name
- NCT07696273
- Testing
- Sensing Device and Tedlar Bags
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease
Diabetes, Exercise and Liver Fat (DELIVER)
This randomised controlled trial will determine if exercise (150 - 200 min per week, 6 weeks) can beneficially modify liver fat quality in non alcohol fatty liver disease patients with type 2 diabetes mellitus (n = 26, 13 per…
- Conditions
- Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity, Insulin Resistance
- Trial name
- (DELIVER) (NCT04004273)
- Testing
- Exercise
- Where
- 4 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- James King
Postprandial Hyperglycemia, Insulin High
The Effects of Vegetable Preloading on Postprandial Glycemia, Insulinaemia and Gastric Emptying
The objective of this study is to investigate the importance of leavy vegetable preloading on the postprandial glycaemic and insulinemic response in human subjects when consumed a specific amount of digestible carbohydrate from…
- Trial name
- APRE (NCT06640335)
- Testing
- Co-ingestion, 0 min preload, 5 min preload
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS)
Isoleucine Addition Treatment Effects in a Controlled Diet Study
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
- Trial name
- ISOLATE (NCT07329088)
- Testing
- L-Isoleucine, Low-isoleucine diet
- Where
- United States
- Sponsor
- Jean L. Fry
Infant, Low Birth Weight, Hyperglycemia
Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion
RATIONALE: Very low birth weight infants have problems maintaining normal blood sugar levels. Gluconeogenesis is the production of sugar from amino acids and fats.
- Trial name
- NCT00005889
- Testing
- alanine, amino acids, glucagon
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Center for Research Resources (NCRR)
Hypertension
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hypertension.
- Trial name
- MEAD (NCT00887510)
- Testing
- Hydrochlorothiazide, Trandolapril
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cerebral Palsy Infantile
Outcome of Very Preterm Infants With Glucose Level Disturbances
The hypothesis of this prospective, cohort study is that hyperglycemia, hypoglycemia and unstable glucose levels in the first seven days of life in infants born very preterm and at very low birth weights can harm long-term…
- Trial name
- NCT03530189
- Testing
- 10% dextrose, bolus of dextrose, reducing the glucose infusion, insulin
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- University Hospital Rijeka
Diabetes, End Stage Renal Disease
Hyperglycemia in Renal Transplantation
Based on multiple prior studies, kidney transplant recipients with diabetes are at higher risk for poor initial graft function after transplant.
- Trial name
- HiRT (NCT01643382)
- Testing
- Insulin, Insulin, Asp(B28)-
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Diabetic Retinopathy
Evaluation of Progression of Diabetic Retinopathy With Rapid Correction of Hyperglycemia
The investigators are doing this research for two reasons. The first is to see how the retina (back of your eye) changes when your blood sugar is treated with medication for the first time.
- Trial name
- NCT02326259
- Testing
- Initiation of treatment of diabetes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Diabetes Mellitus, Type 1
Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00434850
- Testing
- Allogeneic Pancreatic Islet Cells, Deoxyspergualin, Antithymocyte globulin
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes, Pre-diabetes
Northern Manhattan Study of Metabolism and Mind
Pre-diabetes, type 2 diabetes, and their related conditions, adiposity and insulin resistance, are more prevalent in minorities Northern Manhattan compared to the general population of the United States.
- Conditions
- Diabetes, Pre-diabetes, Cognition - Other, Depressive Symptoms
- Trial name
- NOMEM (NCT02470260)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hyperglycemia
Effect of Resistant Starch Type 4 on Glycemia and Insulin Sensitivity in Young Adults
This study tested the effects of resistant starch type 4 on blood sugar and hunger in young adults with Type 2 diabetes.
- Trial name
- NCT00687960
- Testing
- Resistant starch type 4 - raw, Resistant Starch Type 4 - Cooked, Dextrose
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Evaluating a Liquid Extract of Carob to Improve Blood Sugar in People With Prediabetes
This study evaluates whether a liquid carob extract can improve blood glucose levels in individuals with prediabetes. Participants are selected according to predefined health criteria and randomly assigned to two groups: one…
- Trial name
- GLIA (NCT07379931)
- Testing
- Carob extract, Control product
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
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