Clinical trials: Elevated Blood Sugar
Respiratory Distress Syndrome, Adult, Sepsis
Early Insulin and Development of ARDS
Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Symptoms usually develop within 24 to 48 hours of an original injury or illness, and people with…
- Conditions
- Respiratory Distress Syndrome, Adult, Sepsis, Hyperglycemia
- Trial name
- NCT00605696
- Testing
- Insulin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albert Einstein College of Medicine
Hyperglycemia, Dietary Modification
Measuring the Glycemic Index and Tracking Metabolites of New and Emerging Lentil Varieties
It is not known whether different lentil varieties have the same efficacy in lowering blood glucose. Similarly, the carbohydrate component of lentils responsible for lowering blood glucose is not known, nor is the bioavailability…
- Trial name
- NCT02909803
- Testing
- Lentil Variety, White Bread
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Pre-diabetes
Therapeutic Intervention of Eriomin Associated with Metformin in the Control of Hyperglycemia in Pre-Diabetic Patients
Citrus bioflavonoids, such as eriocitrin, hesperidin and naringin, have been shown improved hyperglycemia, insulin resistance and systemic inflammation, related to the development of type 2 diabetes.
- Trial name
- Eriomin+Met (NCT06005142)
- Testing
- Eriomin, Washout
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Thais Cesar
Diabetes, Pre Diabetes
Diabetes Prevention and Education
Type 2 diabetes mellitus is one of the fastest growing public health problems in developed and developing countries and imposes a large financial burden on health-care systems.
- Conditions
- Diabetes, Pre Diabetes, Fatty Liver, Body Weight Changes
- Trial name
- NCT05769127
- Testing
- Diabetes Prevention Program (DPP), Diabetes Self-Management Training (DSMT)
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Pre-Diabetic
Effect of 1,25-dihydroxyvitamin D3, Treatment on Insulin Secretion and Muscle Strength in Pre-diabetic Persons
The purpose of this research is to study the effects of 1,25(OH)2 D3 (a prescription form of active Vitamin D) on muscle strength and insulin secretion by the pancreas and glucose utilization by skeletal muscle.
- Trial name
- NCT04286529
- Testing
- Calcitriol capsules
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 1 Diabetes, Pancreatectomy; Hyperglycemia
Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
In this study, liver samples will be collected, processed and stored in a specialized, clinical grade, cell bank for potential future clinical use.
- Trial name
- NCT04038931
- Testing
- Liver biopsy collection
- Volunteers
- 20 people
- Sponsor
- Orgenesis Ltd.
Pre-diabetes, Diabetes
OGTT at Home Using CGM vs at the Clinic
This randomized, crossover study evaluates the feasibility and accuracy of a self-administered oral glucose tolerance test (OGTT) at home using continuous glucose monitoring (CGM) compared to a standard clinic-based OGTT.
- Trial name
- OGTT-CGM (NCT06862128)
- Testing
- OGTT at home using CGM, OGTT at the clinic
- Where
- 3 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Linkoeping University
Sepsis, Hyperglycemia
Clinical Validation of Continuous Glucose Monitoring in Glycemic Management of Critically Ill Sepsis Patients
Poor glycemic control is common in critically ill patients with sepsis and is associated with increased morbidity and mortality; however, achieving safe and effective glucose management in the ICU remains challenging with…
- Conditions
- Sepsis, Hyperglycemia, Glycemic Control
- Trial name
- NCT07686939
- Testing
- Continuous Glucose Monitoring (CGM) with FreeStyle Libre II System
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Pediatric Surgery
Effect of Using Dextrose-containing Intraoperative Fluid in Children
The glucose-containing fluid was preferred for maintenance fluid in pediatric surgery to prevent hypoglycemic events. This practice can lead to intraoperative hyperglycemia which can induce osmotic diuresis and consequently…
- Trial name
- NCT05061836
- Testing
- Ringer acetate, 1.25%Dextrose equivalence, 2.5%Dextrose equivalence
- Where
- Thailand
- Volunteers
- 68 people
- Sponsor
- Mahidol University
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Hyperglycemia
Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health
The study aims to assess whether a nutritional drink taken before conception and continuing through pregnancy, assists in the maintenance of healthy glucose metabolism in the mother and promotes offspring health.
- Trial name
- NiPPeR (NCT02509988)
- Testing
- Study nutritional drink, Standard nutritional drink
- Where
- 3 sites in New Zealand, Singapore and 1 more
- Volunteers
- 1,729 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Healthy
Glycemic and Insulinemic Index Determination of Two Products: Fructilight® and A Fruit Fructo-Oligosaccharides in Sweet Matrix
The aim of the study is to determine glycemic and insulinemic index of 2 sweet syrups : FructiLight® and fruit Fructo-oligosaccharides in sweet matrix compared to glucose.
- Trial name
- IGNUT (NCT01343797)
- Testing
- Glycemic and insulinemic index tests of a fruit fructose syrup and a fruit fructo-oligosaccharid syrup
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CRITT Bio-Industries
Diabetes
Assessment of Response Rates and Yields for Two Tools for Early Detection of Non-diabetic Hyperglycaemia and Diabetes
The purpose of this study is to establish the most effective method of increasing attendance to screening of type 2 Diabetes within a primary care setting within the backdrop of the NHS Health Check programme.
- Trial name
- ATTEND (NCT00950313)
- Testing
- Self Assessment, Electronic risk score
- Where
- United Kingdom
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Metabolic Syndrome
Effects of Genistein in Postmenopausal Women With Metabolic Syndrome
The 15-25% of the population of developed countries suffers for metabolic syndrome. It is associated with a 2-4 fold increase in cardiovascular morbility and mortality and with a 5- 9 fold increase in developing type II diabetes.
- Trial name
- NCT01664650
- Testing
- Genistein
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- University of Messina
Impaired Glucose Tolerance (IGT), Diabetes
Acute Effect of Exenatide on Brain Glucose Metabolism
This research study will examine brain glucose metabolism after an overnight fast to determine the effect of exenatide on brain glucose metabolism and lipid metabolism.
- Trial name
- NCT01588418
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Hyperglycemia, Diabetes
Effects of Hyperglycemia During Cardiopulmonary Bypass on Renal Function
To determine whether intraoperative hyperglycemia potentiates renal injury in the setting of cardiac surgery requiring cardiopulmonary bypass.
- Trial name
- NCT00404950
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Hyperglycemia
Barriers to the Implementation of Complete Insulin Order Sets
The major purpose of this Quality Improvement project is to begin to address the issues surrounding glycemic control in the hospital setting by collecting accurate, reliable and verifiable data on the occurrence of hyperglycemia…
- Trial name
- NCT00813280
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- HealthPartners Institute
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482610
- Testing
- Glucose, Glucose with Whole Fat Milk, Glucose with Non-fat Milk
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Hyperglycemia, Craniotomy
Impact of Severe Intraoperative Hyperglycemia on Infection Rate After Elective Intracranial Interventions
Severe intraoperative hyperglycemia (SIH) is recognized as one of the important risk factors for the increasing of the postoperative infections rate, which can negatively affect the final outcome of surgical treatment.
- Conditions
- Hyperglycemia, Craniotomy, Infection Post Op
- Trial name
- NCT04285359
- Testing
- Intracranial Interventions
- Where
- 2 sites in Italy, Russia
- Volunteers
- 514 people
- Sponsor
- Burdenko Neurosurgery Institute
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