Clinical trials: Elevated Blood Sugar
Diabetes
Together on Diabetes Study: Evaluation of a Pilot Diabetes Prevention and Management Program for American Indian Youth
The objective of the Together on Diabetes study is to test the efficacy of a pilot intervention to improve the prevention and management of type 2 diabetes among American Indian youth.
- Trial name
- NCT01910727
- Testing
- Together on Diabetes-Hopkins
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hyperglycemia
The Effects of add-on Anti-diabetic Drugs in Type 2 Diabetic Patients
Recently, there are some new classes of anti-diabetic drugs availible in Taiwan. In this study, we will observe the change in inflammation and energy homeostasis in type 2 diabetic outpatient, who receiving a new anti-diabetic…
- Trial name
- NCT02885922
- Testing
- anti-diabetic drug
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- Taichung Veterans General Hospital
Type 1 Diabetes
Effectiveness of Aerobic Exercise to Mitigate Hyperglycemia After Fasted Resistance Exercise
Certain types and timings of exercise are known to cause hyperglycemia (high blood glucose) in people with type 1 diabetes. Hyperglycemia increases the risk of most long-term complications for individuals with this complication.
- Trial name
- NCT05203653
- Testing
- Resistance exercise only, Resistance exercise plus cool down
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Hyperglycemia
Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation
Glycemic control can be safely achieved in surgical and medical intensive care unit settings and has been shown to improve short and long-term clinical outcomes.
- Trial name
- NCT00779701
- Testing
- Insulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Temple University
Pre Diabetes, Insulin Resistance
Exenatide and Weight Loss for Diabetes Prevention
Exenatide, a GLP-1 agonist approved for lowering blood glucose concentrations in patients with type 2 diabetes, has been associated with restoration of the first-phase insulin response when administered intravenously to patients…
- Trial name
- NCT02084654
- Testing
- Exenatide 5 and 10 mcg 2 times a day
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hyperlipidemias, Hyperglycemia
Golden Black Seed: Support of Metabolic Health and General Wellness.
To document effects of consuming Golden Black Seed (brand: New Chapter Inc.) on metabolic health and wellness in human subjects.
- Trial name
- NCT03643094
- Testing
- Golden Black Seed
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Obesity, Insulin Resistance
Resveratrol and the Metabolic Syndrome
Metabolic syndrome is a serious health condition that affects about 35 percent of adults and places them at higher risk of cardiovascular disease, diabetes, stroke and diseases related to fatty buildups in artery walls.
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT01714102
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Hyperglycemia, Postprandial
Effect of Baobab Fruit on Postprandial Glycaemia in Healthy Adults
Baobab fruits have been traditionally used in Africa due to its therapeutic proprieties attributed to it high polyphenol content.
- Trial name
- NCT05140629
- Testing
- Baobab fruit aqueous extract
- Where
- Portugal
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Diabetes, Obesity
A Culturally Tailored Lifestyle Intervention to Prevent Diabetes in South Asians
The South Asian Community, people with origins in India, Pakistan, Bangladesh, Maldives, Nepal, Sri Lanka, or Bhutan, are more likely to get diabetes, get diabetes at younger ages, and do worse health-wise once they have diabetes…
- Trial name
- SHAPE (NCT01084928)
- Testing
- Lifestyle Intervention Classes
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Hyperglycemia, Diabetes
Diabetes in the Perioperative Period
High blood glucose levels in surgical patients with and without diabetes are associated with increased risk of medical complications and death.
- Trial name
- NCT00738114
- Where
- United States
- Volunteers
- 3,184 people
- Sponsor
- Emory University
Pediatric Patient (1m-21y), ICU Admission
Pediatric Intensive Care Units (ICUs) at Emory-Children's Center Glycemic Control: The PedETrol Trial
The primary goal of this project is to determine whether normalizing hyperglycemia is a safe approach to improve multisystem organ function in critically ill children requiring intensive care.
- Conditions
- Pediatric Patient (1m-21y), ICU Admission, Hyperglycemia
- Trial name
- PedETrol (NCT01116752)
- Testing
- Active Glycemic Control Strict (80-140mg/dL) vs. Conservative (190-220mg/dL) (with or without Continuous Glucose Monitoring)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Indiana University
IGT - Impaired Glucose Tolerance, T2D
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes
Type 2 Diabetes (T2D) in obese youth is often preceded by a prediabetic state called: Impaired Glucose Tolerance (IGT), which is associated with a pre-existing defect in insulin secretion.
- Trial name
- NCT03195400
- Testing
- Oral Glucose Tolerance Test, Hyperglycemic Clamp, Isoglycemic Intravenous Glucose Test
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Hyperglycemia, Cardiac Surgery
Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients
The purpose of this study is to evaluate the safety and efficacy of a system combining continuous glucose measurement with a computer-based algorithm for insulin delivery in patients undergoing elective cardiac surgery.
- Trial name
- NCT00996099
- Testing
- Continuous glucose monitoring system combined with enhanced model predictive control algorithm for intensive insulin treatment, Intensive insulin therapy using standard protocol
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Charles University, Czech Republic
Pre-diabetic
Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels
This study aims to determine whether the use of a supplement called xylooligosaccharide (XOS) increases the number of good bacteria that live in human intestines and can maintain healthy blood sugar levels, and whether XOS has…
- Trial name
- XOS2 (NCT01944904)
- Testing
- Sugar Pill, XOS 2.8
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Critical Illness
Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets.
- Trial name
- NCT03003507
- Testing
- Enteral Formula With Fructose, Enteral Formula Without Fructose
- Volunteers
- 25 people
- Sponsor
- Hospital Moinhos de Vento
Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic)
Comparing Glycemic Outcomes of Carbohydrate Counting vs. Fixed Mealtime Insulin Dosing in Hospitalized Patients With Hyperglycemia
The study compares two current practices for calculating insulin dose for admitted patients: flexible fixed mealtime dosing based on percent of meal eaten and carbohydrate counting based on amount of carbohydrates eaten.
- Conditions
- Diabetes Type 2 on Insulin, Hypoglycemia (Diabetic), Hyperglycemia Due to Type 2 Diabetes Mellitus
- Trial name
- MEND (NCT07808398)
- Testing
- Carbohydrate-counting-based prandial rapid-acting insulin dosing, Flexible fixed mealtime rapid-acting insulin dosing based on percentage of meal consumed
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Hyperglycemia
Inpatient Self Monitoring and Administration Study (ISMAS)
ISMAS is designed to test the hypothesis that self management of insulin dependent diabetes mellitus by selected patients admitted for elective surgery is more efficacious than standard care with respect to overall glycemic…
- Conditions
- Diabetes Mellitus, Hyperglycemia, Hypoglycemia
- Trial name
- ISMAS (NCT00506272)
- Testing
- Self blood glucose monitoring and insulin administration, Standard care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Atlanta VA Medical Center
Insulin Sensitivity, Glucose Intolerance
Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function
Type 2 diabetes results from a combination of peripheral insulin resistance and beta-cell dysfunction, and manifests as fasting and postprandial hyperglycemia.
- Conditions
- Insulin Sensitivity, Glucose Intolerance, Insulin Resistance, Energy Supply; Deficiency
- Trial name
- NCT03264001
- Testing
- Negative energy balance
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
End-stage Renal Disease
The Effect of the Incretin Hormones on the Endocrine Pancreatic Function During Hyperglycemia in End-stage Renal Disease
Patients with end-stage renal disease (ESRD) have a high prevalence of impaired glucose metabolism. The pathophysiological cause is uncertain, but disturbances in the secretion, elimination and effect of glucagon, insulin and the…
- Trial name
- NCT02237521
- Testing
- Eu- and hyperglycemic clamp, Arginine test
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bo Feldt-Rasmussen
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