Clinical trials: Elevated Blood Sugar
Pre Diabetic, Pre Diabetes
Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults
This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two…
- Trial name
- NCT07061496
- Testing
- Moderately intense exercise, MetFORMIN 500 Mg Oral Tablet
- Where
- Pakistan
- Volunteers
- 226 people
- Sponsor
- Asad Ullah Jan
Type 2 Diabetes
Evaluation of Correlations Between Volatile Organic Compounds and Venous Blood Glucose in Subjects With Type 2 Diabetes
The goal of this study is to evaluate correlations between VOCs in the breath and venous blood glucose values in various glycaemic states in people living with Type 2 Diabetes.
- Trial name
- Evo (NCT07147010)
- Testing
- MIB Breath Analyzer
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- DCB Research AG
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Diabetes Mellitus, Gestational
Effects of Vitamin D and Calcium on Hyperglycemia and Dyslipidemia in Patients Gestational Diabetes
Gestational diabetes mellitus (GDM) is becoming more common globally as a metabolic disease that occurs during pregnancy and influences the mother and the fetus.
- Trial name
- NCT06896669
- Testing
- vitamin D3
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Impaired Glucose Tolerance
Effect of Saxagliptin Treatment on Myocardial Fat Content, and Monocyte Inflammation
The purpose of the study is to examine the effect of saxagliptin, an anti-diabetes medication, on hepatic and myocardial fat content and monocyte inflammation in patients with Impaired Glucose Tolerance (IGT).
- Trial name
- NCT01548651
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Gestational Diabetes Mellitus, Pre-diabetes
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
Our goal is to test whether shared decision making for diabetes prevention can help women with a history of gestational diabetes mellitus (GDM) who are at high risk of developing type 2 diabetes (T2DM) increase weight loss and…
- Conditions
- Gestational Diabetes Mellitus, Pre-diabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT04897945
- Testing
- Shared decision-making for diabetes prevention
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes, Pre-Diabetes
Sugar Challenge Study
This is a longitudinal study involving use of the January App which collects multiple data streams and employs machine learning techniques to offer personalized lifestyle recommendations and structured food and activity…
- Conditions
- Type 2 Diabetes, Pre-Diabetes, Healthy
- Trial name
- NCT04621656
- Testing
- January Mobile Application (Sugar AI)
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- January, Inc.
Systemic Inflammatory Response Syndrome, Hyperglycemia
The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome.
- Trial name
- AM (NCT00459511)
- Testing
- Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 1
Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT)
The overall objective of this study is to investigate the glycemic response of a 0%, 50%, 100% and 150% bolus insulin correction (based on personal insulin correction factor) of post-exercise hyperglycemia in physically active…
- Trial name
- FIT (NCT03057470)
- Testing
- 50% bolus insulin correction, 100% bolus insulin correction, 150% bolus insulin correction
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Aging, Glucose Intolerance
Regulation of B-Cell Function & Glucose Tolerance in Older People
This VA CDA-2 proposal will test in detail if lifestyle intervention with aerobic exercise training improves the body's production of insulin in older people at risk to develop diabetes.
- Trial name
- NCT00554112
- Testing
- Exercise
- Volunteers
- 90 people
- Sponsor
- US Department of Veterans Affairs
Pre-diabetes
Efficacy of Whole-body Electromyostimulation (WB-EMS) Training in Participants With Pre-diabetes
The goal of this pilot study is to assess the efficacy of the intervention (WB-EMS Training) in a sedentary group of adults with pre-diabetes and to estimate the potential effect sizes.
- Trial name
- NCT06188481
- Testing
- whole-body electromyostimulation training, activity tracker, evidence-based lifestyle education program
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes, Hyperglycemia
Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM)
The study is a prospective randomized study comparing safety and effectiveness of a basal-bolus regimen with glargine once daily and glulisine before meals, a basal plus regimen with glargine once daily and supplemental doses of…
- Trial name
- Basal-Plus (NCT00979628)
- Testing
- sliding scale regular insulin (SSRI), Basal Bolus, Basal Plus
- Where
- 5 sites in United States
- Volunteers
- 375 people
- Sponsor
- Guillermo Umpierrez, MD
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Hyperglycemia, Type 1 Diabetes Mellitus
The Influence of Acute Hyperglycaemia on Brain in T1D
The study is going to include 20 adolescents, 5-10 years after onset of T1D, aged 12-20 years, on insulin pump. The participants are going to have MRI of the head in euglycaemic and hyperglycaemic state.
- Trial name
- NCT03188757
- Testing
- hyperglycaemic clamp
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diabetes Mellitus, Type 2, Pre Diabetes
Prediabetes Intervention With Tea
The goal of this interventional study is investigating the effect of the daily consumption of olive leaves tea on glycemic control of individuals diagnosed with pre-diabetes.
- Trial name
- PREVENT (NCT05583045)
- Testing
- Olive Leaf Tea, Lifestyle behavior change program (LBC)
- Where
- Portugal
- Volunteers
- 140 people
- Sponsor
- Instituto Politécnico de Bragança
Pre Diabetes
Effects of Mango on Insulin Sensitivity in Prediabetes
The purpose of this study is to determine whether daily mango consumption for 6 weeks can improve glucose utilization in individuals with prediabetes.
- Trial name
- MG4 (NCT07886372)
- Testing
- Mango juice, Control Beverage
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Pre-diabetes
Effects of Lean Pork, High Protein Breakfast on Satiety and Metabolic Health in Pre-diabetes
The goal of this study is to assess the effects of consumption of a lean pork-containing, high-protein breakfast versus a refined carbohydrate-rich breakfast on satiety and cardiometabolic parameters in overweight or obese adults…
- Trial name
- NCT02934425
- Testing
- Refined carbohydrate-rich breakfast, High pork protein breakfast
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Diabetes, Heart Failure
A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)
The Ahmanson-UCLA Cardiomyopathy Center is conducting a clinical research study that will assess the use of the medication metformin to improve quality of life, exercise capacity, and improved outcomes in heart failure patients…
- Trial name
- NCT01573949
- Testing
- Metformin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease, Glucose Intolerance
Exercise Training, Insulin Resistance and Coronary Artery Disease
The purpose of this study was to determine the effects of exercise training on insulin resistance in subjects with coronary artery disease independent of changes in weight, diet, or the effect of an acute bout of exercise.
- Trial name
- NCT00412815
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Microvascular Dysfunction (CMD), Index of Microvascular Resistance
SHR Predicts CMD in Patients with CCS
SHR exerts a significant influence in numerous cardiovascular diseases, including MINOCA (myocardial infarction with non - obstructive coronary arteries), HFpEF (heart failure with preserved ejection fraction), and CAD (coronary…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Index of Microvascular Resistance, Chronic Coronary Syndrome, Prognosis
- Trial name
- SHR-CMD-CCS (NCT06698432)
- Testing
- caIMR
- Volunteers
- 379 people
- Sponsor
- Ya-Wei Xu
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