Clinical trials: Elevated Intracranial Pressure
Idiopathic Intracranial Hypotension, Venous Sinus Stenosis
Stent Implantation Versus Medical Therapy for Idiopathic IntracraniaL Hypertension (SIMPLE)
The aim of this study is to assess the efficacy of stent implantation versus medical therapy on idiopathic intracranial hypertension with venous sinus stenosis.
- Trial name
- NCT05707442
- Testing
- Stent Implantation, Acetazolamide-based medical therapy, Weight loss
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Tiantan Hospital
Pseudotumor Cerebri
Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension
This prospective study will use magnetic resonance imaging of patients with Idiopathic Intracranial Hypertension (IIH), to determine if the common radiological finding of transverse venous sinus stenosis can be reversed with…
- Trial name
- NCT02394067
- Testing
- Radiological Imaging
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Upper Limb Injury, Intracranial Pressure Increase
Evaluation of Supraclavicular Brachial Plexus Blocks at Various Volumes: Impact on Optic Nerve Sheath Diameter
This study aimed to evaluate the anesthesia adequacy, side effects, and complication rates, as well as the postoperative pain relief effectiveness of supraclavicular brachial plexus blocks administered at different volumes under…
- Trial name
- NCT06428461
- Testing
- Supraclavicular brachial plexus block, Measurement of Optic Nerve Sheath Diameter (ONSD) Using B-Mode Ultrasound, Assessment of Peripheral Nerve Block Success Using Perfusion Index Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Pamukkale University
Presence of High Intracranial Pressure
An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an External Ventricular Drainage (EVD) Device
Invasive intracranial pressure (ICP) monitoring is highly effective, but involves risks. HS-1000 measures ICP non-invasively by assessing the acoustic properties of the patient's head.
- Trial name
- NCT02284217
- Testing
- EVD
- Where
- 7 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- HeadSense Medical
Brain Injuries, Intracranial Pressure Increase
Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients
The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of…
- Conditions
- Brain Injuries, Intracranial Pressure Increase, Monitoring
- Trial name
- Mespere ICP (NCT06511804)
- Testing
- Intracranial Pressure Noninvasive Monitoring
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Louisville
Acute Liver Failure, Hepatic Encephalopathy
The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
The main objective of this study is to investigate the effect of Prometheus liver support dialysis on intracranial pressure, cerebral metabolism and circulation in patients with acute liver failure.
- Conditions
- Acute Liver Failure, Hepatic Encephalopathy, Intracranial Hypertension
- Trial name
- NCT00655304
- Testing
- Prometheus (R) liver support dialysis, CVVHDF (Continuously Veno-Venous Hemodiafiltration)
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hydrocephalus, Intracranial Hypertension
Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter
External ventricular catheters are used for intracranial pressure monitoring and temporary cerebrospinal fluid (CSF) drainage in neurosurgery.
- Trial name
- NCT00286104
- Testing
- Antibiotics-impregnated ventricular catheter (Bactiseal®), Plain ventricular catheter (Codman EDS II/III)
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Chinese University of Hong Kong
Intracranial Hypertension
Optic Nerve Sheath Diameter and Intracranial Pressure (ICP) in Children
The use of optic nerve sheath diameter (ONSD) measurements as a non invasive test for raised ICP has many potential benefits. This includes having assessments that can be made at the bedside instead of requiring patient transport…
- Trial name
- NCT02507063
- Testing
- ultrasound
- Sponsor
- Anna Rominger
Intracranial Hypertension, Endotracheal Intubation
Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy.
- Conditions
- Intracranial Hypertension, Endotracheal Intubation, Optic Nerve Sheath Diameter, General Anesthesia
- Trial name
- NCT06254534
- Testing
- optic nerve ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Haseki Training and Research Hospital
Malignant Media Infarction, Stroke
Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study
The goal of the ONSITE study is to investigate whether an increase Optic nerve sheath diameter (ONSD) may help to predict intracranial hypertension (IH) after stroke.
- Conditions
- Malignant Media Infarction, Stroke, Intracranial Hypertension
- Trial name
- ONSITE (NCT06939114)
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- University of Zurich
Traumatic Brain Injury, Intracranial Hypertension
Effect of Ketamine (Ketalar) on Intracranial Pressure
Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency…
- Trial name
- NCT00437814
- Testing
- Ketamine, effect on intracranial pressure
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Intracranial Pressure Increase, Cerebral Edema
Noninvasive Monitoring of Cerebral Blood Flow Autoregulation
Rheoencephalography (REG) shows promise as a method for noninvasive neuromonitoring, because it reflects cerebrovascular reactivity. This protocol will study clinical and technical conditions required to use REG.
- Trial name
- NCT05170295
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ochsner Health System
Intracranial Pressure Increase
Change of Optic Nerve Sheath Diameter After Deflation of Pneumatic Tourniquet
The purpose of this study is to evaluate the change of the optic nerve sheath diameter after deflation of pneumatic tourniquet.
- Trial name
- NCT03782077
- Testing
- Deflation of pneumatic tourniquet
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Brachial Plexus Block, Intracranial Pressure Increase
The Effect of Interscalene Block on Intracranial Pressure
The study aims to show the effects of interscalene brachial plexus (ISBP) block on intracranial pressure by measuring optic nerve sheath diameter (ONSD) and internal vein collapsibility index (IJV-CI).
- Trial name
- NCT05434975
- Testing
- Interscalene brachial plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Hydrocephalus, Idiopathic Intracranial Hypertension
Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement
This research is being done to determine the accuracy of two noninvasive methods of measuring the pressure of the cerebrospinal fluid (CSF), also known as intracranial pressure or ICP.
- Conditions
- Hydrocephalus, Idiopathic Intracranial Hypertension, Pseudotumor Cerebri
- Trial name
- NCT01863381
- Testing
- Tympanic membrane displacement (TMD), DPOAE
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- LifeBridge Health
Idiopathic Intracranial Hypertension
Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a syndrome characterized by elevated intracranial pressure (ICP) of unknown etiology.
- Trial name
- NCT03963336
- Testing
- LMWH, acetazolamide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Assessment of ONSD, ODE and the Crescent Sign Using POCUS
Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign
Our aim was to determine the diagnostic accuracy of the ONSD, ODE, and crescent sign, as detected by POCUS, in identifying the clinical and radiological features of increased intracranial pressure.
- Trial name
- NCT07719842
- Testing
- Ultrasound assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Intracranial Pressure Increase, Traumatic Brain Injuries
TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI
This study will evaluate two non-invasive ultrasound methods, transcranial Doppler (TCD) and optic nerve sheath diameter (ONSD) ultrasound, for detecting signs of increased intracranial pressure in adults with traumatic brain…
- Trial name
- TCD ONSD TBI (NCT07816588)
- Testing
- Transcranial Doppler (TCD), Optic Nerve Sheath Diameter (ONSD) Ultrasound
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Intracranial Pressure Increase, Supraglottic Airway Device
Effect of Different Supralottic Airway Devicess on Optic Nerve Sheath Diameter
Direct laryngoscopy and tracheal intubation are associated with increases in intraocular pressure (IOP), intracranial pressure (ICP), heart rate (HR), and blood pressure.
- Conditions
- Intracranial Pressure Increase, Supraglottic Airway Device, Optic Nerve Sheath Diameter
- Trial name
- NCT05499754
- Testing
- pLMA: PROSEAL LARYNGEAL MASK, sLMA : SUPREMA LARYNGEAL MASK, I-jel =I-GEL
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Intracranial Hypertension, Elevated ICP (Intracranial Pressure)
A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension
There is statistically significant correlation between invasive measures of intracranial pressure (ICP) and non-invasive, real-time, continuous physiologic waveform data algorithms to predict ICP.
- Trial name
- NCT01448681
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver