Clinical trials: Elevated Intracranial Pressure
Increased Intracranial Pressure
Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
The overall purpose of this study is to compare the effects of mannitol and hypertonic saline on patients with increased intracranial pressure.
- Trial name
- NCT00359697
- Testing
- Hypertonic Saline, Mannitol
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Idiopathic Intracranial Hypertension (IIH)
Dural Venous Sinus Stent in Idiopathic Intracranial Hypertension
This study aims to identify clinical determinants and factors that predict outcome including primary outcome and secondary outcome depending on factors in individual patients with Idiopathic intracranial hypertension treated by…
- Trial name
- NCT06833424
- Testing
- Dural venous sinus stenting
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Intracranial Hypertension, Cerebral Circulatory Failure
Cerebral Compliance Impairment in COVID-19
Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing…
- Trial name
- NCT04429477
- Testing
- Cerebral compliance and hemodynamics monitoring
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Idiopathic Intracranial Hypertension
Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment
This study aims to investigate the safety and efficacy of semaglutide in patients with Idiopathic intracranial hypertension.
- Trial name
- NCT06361823
- Testing
- Semaglutide, Low calorie diet
- Volunteers
- 74 people
- Sponsor
- Capital Medical University
Intracranial Pressure Increase
Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section
General anesthesia and regional anesthesia can be chosen in cesarean operations. Endotracheal intubation and mechanical ventilation are components of general anesthesia.
- Trial name
- NCT04446013
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Intracranial Hypertension, Brain Edema
Optical Nerve Sheath Changes During Head Down Laparoscopy
Patient undergoing laparoscopic radical prostatectomy in steep trendelenburg position are at risk to develop complication from brain edema.
- Conditions
- Intracranial Hypertension, Brain Edema, Pneumoperitoneum, Surgery, Laparoscopic
- Trial name
- NCT03957837
- Testing
- Optical nerve sheath diameter ultrasound measurement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Intracranial Hypertension
Comparison of the Non-invasive ICP HeadSense Monitor vs Lumbar CSF Pressure Measurement
In current practice patients with a suspected increase of intracranial pressure (ICP) will undergo a lumbar puncture with measurement of cerebral spinal fluid (CSF) pressure (as a marker for ICP).
- Trial name
- NCT02773901
- Testing
- HS-1000
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- HeadSense Medical
Brain Injuries, Traumatic, Traumatic Brain Injury
Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
The specific aim of this research is to determine if the blood from brain-injured patients contains reproducible protein markers that appear prior to elevations in intracranial pressure (ICP).
- Trial name
- Proteomics (NCT00178659)
- Testing
- Blood/saliva samples for protein/molecular analysis
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Intracranial Hypertension
Clinical Value of Noninvasive Intracranial Pressure Measurement
The aim of the study is to evaluate accuracy and precision of non-invasive intracranial pressure measurement device (Vittamed 205) for selected patients compared with cerebrospinal fluid pressure measured during lumbar puncture
- Trial name
- Braincare (NCT02130219)
- Testing
- Non-invasive intracranial pressure measurement, Brain MRI/CT, Lumbar puncture and cerebrospinal fluid pressure measurement
- Where
- Lithuania
- Volunteers
- 45 people
- Sponsor
- Lithuanian University of Health Sciences
Intracranial Hypertension, Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies
Measurement of the diameter of the sheath of the optic nerve in patients hospitalized in intensive care, with increased intracranial pressure (> 20mmHg) as a substitute measure for diagnosis and follow-up before and after…
- Trial name
- NCT03634176
- Testing
- optical nerve sheet diameter
- Where
- Venezuela
- Volunteers
- 90 people
- Sponsor
- Hospital Dr. Miguel Pérez Carreño
Cerebral Oxygenation, Low Flow Anesthesia
The Effect Of Low-Flow And Hıgh-Flow Anesthesıa On Intracranıal Pressure
This prospective randomized study was conducted to evaluate the effects of low-flow and high-flow anesthesia on intracranial dynamics and cerebral oxygenation in patients undergoing laparoscopic hysterectomy in the Trendelenburg…
- Conditions
- Cerebral Oxygenation, Low Flow Anesthesia, Optic Nerve Sheath Diameter Measurement
- Trial name
- NCT07514026
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa City Hospital
Intracranial Hypertension
Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure (ICP)
In this study the invistigators chose to measure the optic nerve sheath diameter by sonography for diagnosis of elevated intracranial pressure (ICP) in comparison to brain computed tomograhy (CT) as the reference gold standard…
- Trial name
- NCT03529370
- Testing
- optic nerve ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Heart Institute, Egypt
Vertebral Venous Collaterals, Serum Uric Acid
Influencing Factors of Intracranial Hypertension in Patients With Bilateral Transverse Sinus Stenosis
Bilateral transverse sinus stenosis (BTSS) is associated with intracranial hypertension (IH). However, not every BTSS patients presented with IH. The risk factors of IH in BTSS patients remained obscure.
- Conditions
- Vertebral Venous Collaterals, Serum Uric Acid, Intracranial Hypertension, Bilateral Transverse Sinus Stenosis
- Trial name
- NCT04492332
- Testing
- standard lumbar puncture
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Capital Medical University
Intracranial Pressure Increase, Traumatic Brain Injuries
TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI
This study will evaluate two non-invasive ultrasound methods, transcranial Doppler (TCD) and optic nerve sheath diameter (ONSD) ultrasound, for detecting signs of increased intracranial pressure in adults with traumatic brain…
- Trial name
- TCD ONSD TBI (NCT07816588)
- Testing
- Transcranial Doppler (TCD), Optic Nerve Sheath Diameter (ONSD) Ultrasound
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Intracranial Hypertension, Abnormality of Intracranial Pressure
Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device
For purposes of validation, this study compares intracranial pressure measurements obtained with a novel self-calibrating, non-invasive, intracranial pressure measuring (ICP) device, with the values obtained from (a) patients in…
- Trial name
- NCT03865576
- Testing
- Non-invasive ICP measurement
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston Neurosciences
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems
Optic Nerve Sheath Diameter
Effect of Different Positive End-Expiratory Pressure (PEEP) Levels on Optic Nerve Sheath Diameter
The goal of this prospective observational study is to evaluate the effects of different PEEP values on the optic nerve sheath diameter (ONSD), a noninvasive indicator of intracranial pressure (ICP), in patients undergoing…
- Trial name
- NCT07085949
- Testing
- 5 cmH2O PEEP, 10 cmH2O PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Izmir City Hospital
Hypertension
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults.
- Trial name
- HIPAC (NCT03354143)
- Testing
- Standard Care, Intensive Treatment
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Elevated Intracranial Pressure (ICP)
Optic Nerve Sheath Diameter in Patients With Intracranial Pathology
Elevated intracranial pressure (ICP) is a common and potentially life threatening condition arising from a variety of pathological conditions. The ability to monitor ICP is a crucial aspect in the management of these patients.
- Trial name
- NCT02361671
- Testing
- Optic Nerve Sheath Diameter using an ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Pseudotumor Cerebri
Pseudotumor Cerebri Headache Ten Years Outcome
Telephone interview on patient who suffered from PTC ten years ago regarding their headache status
- Trial name
- NCT06581185
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center