Clinical trials: Elevated Risk of Cardiovascular Disease
Chronic Kidney Diseases, Chronic Kidney Insufficiency
The Cost Effectiveness and Evaluation of Disease Management of Chronic Kidney Disease and High Risk Population
This study is being implemented for 3 aims. The first has been to conduct a systematic literatures review on CKD intervention models and their effectiveness. Findings have been adopted in our intervention program.
- Trial name
- NCT02034149
- Testing
- general management, self-management, peer-assisted management
- Where
- Taiwan
- Volunteers
- 411 people
- Sponsor
- China Medical University Hospital
Overweight, Obesity
Glycemic Load, Weight Loss and Cardiovascular Disease Risk
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors.
- Trial name
- NCT00254215
- Testing
- high protein & low glycemic index diets
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Cardiovascular Diseases
Elucidating the High Cardiovascular Disease Risk in South Asians
The goals of this cross-sectional study are to compare immune cell composition and release of incretin hormones following a meal in healthy Dutch South Asians and Dutch Europids.
- Trial name
- CAMI (NCT05829018)
- Testing
- Mixed meal test
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
Type 2 Diabetes, Cardiovascular Risk
Canagliflozin and Myocardial Fibrosis
Recently, large clinical intervention studies have demonstrated the cardiovascular protective effects on of sodium-glucose cotransporter 2 inhibitors (SGLT2i) such as empagliflozin, dapagliflozin, and canagliflozin in reduction…
- Trial name
- CANA-DIA-FIB (NCT05367063)
- Testing
- Canagliflozin 100mg or Sitagliptin 100mg
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Valve Disease, Coronary Artery Disease
Nasal Oxygen Therapy After Cardiac Surgery
NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation, inclusive of up to one hour off randomised therapy for transfers around the hospital and/or physio…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Respiratory Failure
- Trial name
- NOTACS (NCT05308719)
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 1,280 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Coronary Disease, Drug Eluting Stent
Comparison One vs Six Months of Dual Antiplatelet Therapy After Implanted Firehawk TM Stent in High Bleeding Risk Patients With Coronary Artery Disease
This study is to assess the clinical non-inferiority of 1 month (short-term) vs 6 months (long-term) of dual anti-platelet therapy in patients undergoing percutaneous intervention implanted sirolimus -eluting stent with abluminal…
- Conditions
- Coronary Disease, Drug Eluting Stent, Percutaneous Coronary Intervention, Dual Antiplatelet Therapy
- Trial name
- NCT03287167
- Testing
- 1 month DAPT, 6 months DAPT
- Where
- China
- Volunteers
- 1,720 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Atrial Fibrillation (AF)
Gastroprotective Efficacy of Rebamipide in Patients With Atrial Fibrillation Treated With DOACs
The goal of this clinical trial is to learn if Rebamipide effective in gastroprotection in patients with atrial fibrillation who are treated with Direct Oral Anticoagulants (DOACs).
- Trial name
- REGATA (NCT07354230)
- Testing
- Rebamipide 100mg, Pantoprazole
- Where
- Russia
- Volunteers
- 210 people
- Sponsor
- Pirogov Russian National Research Medical University
Hypertension ,Pregnancy, Diabetes During Pregnancy
Impact of Exercise Prescription on Obstetric and Neonatal Outcomes
The aim of this study is to assess the impact of structured physical activity with smartwatch remote monitoring on glycemic control, blood pressure control, obstetric complications and neonatal outcomes in women with GDM, chronic…
- Conditions
- Hypertension ,Pregnancy, Diabetes During Pregnancy, Obesity (BMI>30)
- Trial name
- NCT07678944
- Testing
- Physical activity plan, Women who received information but did not engaged in a physical activity routine
- Where
- Portugal
- Volunteers
- 310 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Elevated Lipoprotein(a)
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Oral SAL0137 in Adults With Elevated Lp(a) and Increased Risk of Cardiovascular Events
This is a randomized, double-blind, placebo-controlled Phase II trial evaluating the efficacy and safety of oral SAL0137 in adults with elevated Lp(a) and high cardiovascular risk.
- Trial name
- NCT07729475
- Testing
- SAL0137 Dose 1, SAL0137 Dose 2, SAL0137 Dose 3
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Chronic Subdural Hematoma, At Risk of Post-operative Recurrence
Embolization of the Middle Meningeal Artery for the Prevention of Chronic Subdural Hematoma Recurrence in High Risk Patients (EMPROTECT)
Standard of care for the management of symptomatic chronic subdural hematomas (SDHs) is neurosurgical burr-hole evacuation followed by drainage. Post-operative recurrence rates may be as high as 10 to 20 %.
- Conditions
- Chronic Subdural Hematoma, At Risk of Post-operative Recurrence, Burr-hole Surgery
- Trial name
- EMPROTECT (NCT04372147)
- Testing
- MMA embolization
- Where
- 12 sites in France
- Volunteers
- 342 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Myeloma
Tadalafil and Lenalidomide Maintenance With or Without Activated Marrow Infiltrating Lymphocytes (MILs) in High Risk Myeloma
This research is being done to find out if altering the immune system by giving activated marrow infiltrating lymphocytes (MILs) can improve outcomes for multiple myeloma patients who receive a standard autologous stem cell…
- Trial name
- NCT01858558
- Testing
- aMIL, No aMIL
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypertension, Vascular Diseases
SPYRAL GEMINI Pilot Study
The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with…
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- SPYRAL GEMINI (NCT06907147)
- Testing
- Multi-Organ Denervation Gemini System
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 175 people
- Sponsor
- Medtronic Vascular
COPD (Chronic Obstructive Pulmonary Disease), CHF (Congestive Heart Failure)
A Pilot Observation and Feasibility Study of Prevora, Integrated Into Homecare Visits of High-risk Adults
Prevora is an antiseptic medication and dental treatment approved by Health Canada for reducing root decay (cavities) in adults at high risk of dental decay. An antiseptic kills germs and harmful bacteria.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), CHF (Congestive Heart Failure), Dialysis, Chronic Metabolic Disorder
- Trial name
- NCT06158633
- Testing
- Prevora
- Volunteers
- 30 people
- Sponsor
- CHX Technologies Inc.
Hypertension
Felodipine Event Reduction Study
FEVER is an investigator-designed, prospective, multicentre,double-bind, randomized, placebo-controlled,parallel-group trial. The primary objective is to compare the long-term effects on the incidence of fatal and non-fatal…
- Trial name
- FEVER (NCT01136863)
- Testing
- Felodipine
- Where
- China
- Volunteers
- 9,800 people
- Sponsor
- Chinese Academy of Medical Sciences
Heart Failure
Notification Of High-Risk Veterans for Access to Heart Failure Prevention
The purpose of this study is to learn whether connecting people at high risk for developing heart failure to a heart doctor (cardiologist) leads to greater use of treatments that can lower that risk.
- Trial name
- NOVA-HF (NCT07910084)
- Testing
- Notification and Cardiology Referral, Notification and Cardiology Referral Plus Care Navigation
- Volunteers
- 250 people
- Sponsor
- Palo Alto Veterans Institute for Research
Cardiovascular Diseases, Acute Coronary Syndrome
Telemedicine in High-Risk Cardiovascular Patients Post-ACS
This is a non-CTIMP randomised controlled trial looking at the utilisation of telemedicine devices to provide remote, clinically necessary, diagnostic information, without the need for hospital attendance that patients will take…
- Trial name
- TELE-ACS (NCT05015634)
- Testing
- Active Arm, Control Arm
- Where
- United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
Heart Disease
SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX®-Trial).
The aim of the investigators' research program is to investigate the effects of perioperative high dose selenium supplementation in high-risk cardiac surgical patients undergoing complicated open heart surgery.
- Trial name
- SUSTAINCSX (NCT02002247)
- Testing
- sodium selenite
- Where
- 23 sites in Canada, Germany
- Volunteers
- 1,400 people
- Sponsor
- Daren K. Heyland
Infection Cardiac, Heart Failure
Tauropace to Prevent Cardiac Implantable Device Infections in Heart Failure Patients
The main purpose of the study is to evaluate the ability of the Tauropace to reduce major cardiac implantable electronic device (CIED) infections through 12-months post-procedure following CIED in heart failure participants.
- Conditions
- Infection Cardiac, Heart Failure, Cardiac Implantable Electronic Device Infections, High Risk
- Trial name
- TRICE-HF (NCT05103267)
- Testing
- Tauropace
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
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