Clinical trials: Elevated Triglycerides, open to volunteers
Hypertriglyceridemia
Russian Extreme Hypertriglyceridemia Registry
The REGGI registry is a prospective, multicenter observational registry in Russia designed to collect data on patients with extreme hypertriglyceridemia (triglyceride levels ≥10 mmol/L).
- Trial name
- REGGI (NCT07508930)
- Where
- 6 sites in Russia
- Volunteers
- 500 people
- Sponsor
- Russian Cardiology Research and Production Center
Healthy Adult Volunteers
A Phase 1 Study of FXR0906 in Healthy Adults With or Without Elevated Triglycerides
This is a phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics effects of a single dose of FXR0906 injection or placebo in Chinese healthy adult…
- Trial name
- NCT07766759
- Testing
- Intervention1: FXR0906 injection, Intervention2: FXR0906 injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fosun Pharmaceutical Industrial Development (Shenzhen) Co., Ltd.
Lipid Metabolism Disorders
Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic Hyperlipidemia
Background: Obesity is known to lead to diseases such as diabetes and high cholesterol (or fats) in the blood (hyperlipidemia). But no one knows why.
- Trial name
- NCT07715890
- Testing
- High fat liquid shake
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Severe Hypertriglyceridemia (sHTG)
CS-121 APOC3 Base Editing in Severe Hypertriglyceridemia
This is an open-label, single-arm, dose-escalation IIT clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid…
- Trial name
- NCT07657780
- Testing
- CS-121
- Where
- China
- Volunteers
- 15 people
- Sponsor
- CorrectSequence Therapeutics Co., Ltd
Coronary Artery Disease, Hyperlipidaemia
Icosapent Ethyl for High-Risk Coronary Plaques Assessed by 18F-NaF PET/CT
This randomized controlled study will evaluate whether icosapent ethyl (IPE) can improve and stabilize high-risk coronary plaques in patients receiving stable low-density lipoprotein cholesterol (LDL-C)-lowering therapy.
- Conditions
- Coronary Artery Disease, Hyperlipidaemia, Hypertriglyceridaemia, Coronary Atherosclerosis
- Trial name
- IPE-NaF (NCT07762755)
- Testing
- icosapent ethyl (IPE), Standard LDL-C-Lowering Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Lipodystrophy (Genetic or Acquired, Non HIV)
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes
Genetic lipodystrophy syndromes are extremely rare, orphan diseases with overall estimated prevalence of less than 2,000 in the United States.
- Trial name
- NCT03087253
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Postprandial Lipemia
Effect of Standardized Large Yellow Tea Extract on Triglyceride Response After a High-Fat Meal in Healthy Adults
This study is a single-center, prospective, open-label, randomized 2×2 crossover controlled trial in healthy adults aged 18 to 45 years.
- Trial name
- NCT07824609
- Testing
- Standardized Large Yellow Tea Extract, Warm Water Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)
Hypertriglyceridemia
a Phase 1b/2a Study of JMT202 Injection in Participants With Hypertriglyceridemia
To evaluate the safety and tolerability of multiple subcutaneous injections of JMT202 injection in Chinese participants with hypertriglyceridemia
- Trial name
- phase Ib/Ⅱa st (NCT07140809)
- Testing
- JMT202 injection
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shanghai JMT-Bio Inc.
Severe Hypertriglyceridemia (sHTG), Hypertriglyceridemia
A Phase III Study to Evaluate the Efficacy and Safety of of DR10624 in Subjects With Severe Hypertriglyceridemia
This is a multicenter, randomized, double-blind, placebo-controlled Phase 3 clinical trial to assess the efficacy and safety of weekly subcutaneous DR10624 injection in adult patients with severe hypertriglyceridemia (sHTG).
- Trial name
- NCT07693777
- Testing
- DR10624 Injection
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Zhejiang Doer Biologics Co., Ltd.
Hyperlipidemia
A Extension Study to Evaluate the Safety and Efficacy of HRS-7249 in Patients With Hypertriglyceridemia
This is a Phase II multi-center, open-label extension (OLE) clinical trial of HRS-7249, a GalNAc-conjugated APOC3-targeted siRNA injection, enrolling two cohorts of participants.
- Trial name
- NCT07799688
- Testing
- HRS-7249 Injection
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Hypertriglyceridemia, Severe Hypertriglyceridemia
A Study to Assess the Safety, Tolerability and Efficacy of ION775
The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).
- Trial name
- NCT07604974
- Testing
- ION775
- Where
- 18 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Hypercholesterolemia, Hypertriglyceridemia
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
VT-20101 is an Open-label, Phase 1b, Single-ascending dose study that will evaluate the safety of VERVE-201 administered to patients with Refractory Hyperlipidemia.
- Conditions
- Hypercholesterolemia, Hypertriglyceridemia, Refractory Hyperlipidemia
- Trial name
- NCT06451770
- Testing
- VERVE-201
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 132 people
- Sponsor
- Verve Therapeutics, Inc.
sHTG, HTG With ASCVD (Diagnosed or at Increased Risk)
A Phase II Study of FXR0906 in Patients With Severe Hypertriglyceridemia or Hypertriglyceridemia With ASCVD.
This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial evaluating the efficacy and safety of FXR0906 in patients with severe hypertriglyceridemia or hypertriglyceridemia with atherosclerotic…
- Trial name
- NCT07889245
- Testing
- FXR0906 injection
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Fosun Pharmaceutical Industrial Development (Shenzhen) Co., Ltd.
Lipid Metabolism Disorders, Hypertriglyceridemia
Differential Thrombogenesis by EPA and DHA Mediated by HDL
The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels.
- Trial name
- NCT06494488
- Testing
- EPA, DHA
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Miriam Hospital
Acute Pancreatitis (AP), Hypertriglyceridemia Acute Pancreatitis
Multicenter Prospective Cohort Study of Hypertriglyceridemia Acute Pancreatitis
Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is the second leading cause in China and is receiving increasing global attention.
- Trial name
- NCT06976099
- Where
- 12 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Cardiovascular Kidney Metabolic Syndrome
Cardiovascular-Kidney-Metabolic Syndrome Registry
The goal of this observational registry study is to learn about cardiovascular-kidney-metabolic syndrome, also called CKMS, among adults receiving care at tertiary care hospitals in India.
- Trial name
- CKMS Registry (NCT07718789)
- Volunteers
- 2,250 people
- Sponsor
- Centre for Chronic Disease Control, India
Familial Chylomicronemia Syndrome (FCS)
CS-121 APOC3 Base Editing in FCS
This is an open-label, single-arm, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid…
- Trial name
- NCT07176923
- Testing
- CS-121
- Where
- China
- Volunteers
- 15 people
- Sponsor
- CorrectSequence Therapeutics Co., Ltd
Diabete Mellitus, Obesity & Overweight
Comparing Two Low-Carbohydrate Diets With a Standard Diet in Type 2 Diabetes
Type 2 diabetes is often accompanied by high blood triglycerides and excess weight, and diet plays a central role in managing these conditions together.
- Conditions
- Diabete Mellitus, Obesity & Overweight, Hypertriglyceridaemia
- Trial name
- NCT07801378
- Testing
- High-Protein Low-Carbohydrate Diet, High-Fat Low-Carbohydrate Diet, Standard diet
- Volunteers
- 168 people
- Sponsor
- National Nutrition and Food Technology Institute
Hypertriglyceridaemia
Abnormal Lipids - Causes and Effects
1. At target LDL-C levels, apoB100 concentrations will be higher than recommended levels in the following populations: 1. Tertiary centre lipid clinic patients with raised TG treated with statins. 2.
- Trial name
- NCT02195050
- Where
- United Kingdom
- Volunteers
- 1,396 people
- Sponsor
- Manchester University NHS Foundation Trust