Clinical trials: Embolism, Pulmonary
Cardiovascular Diseases
Standard vs Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study is an investigator-initiated trial comparing two different catheters (standard versus ultrasound assisted) for the treatment of acute high risk pulmonary embolism (blood clots in lung arteries with evidence or heart…
- Trial name
- NCT03086317
- Testing
- Standard Catheter-Directed Thrombolysis, Ultrasound-Accelerated Thrombolysis
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Pulmonary Embolism
Catheter Directed Interventions in Pulmonary Embolism
Evaluating the safety and outcomes of catheter directed thrombolysis following catheter fragmentation in acute high risk pulmonary embolism
- Trial name
- NCT03595085
- Testing
- catheter directed fragmentation and thrombolysis, Streptokinase
- Volunteers
- 60 people
- Sponsor
- Assiut University
Symptomatic Venous Thromboembolism (VTE)
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA).
- Trial name
- ROXI-ASPEN (NCT07213778)
- Testing
- REGN7508, Acetylsalicylic Acid (ASA)
- Where
- 51 sites in United States, Greece and 3 more
- Volunteers
- 2,000 people
- Sponsor
- Regeneron Pharmaceuticals
Pulmonary Embolism
Catheter-directed Thrombolysis in Intermediate-high Risk Acute Pulmonary Embolism
Background: Intermediate-high risk acute pulmonary embolism (PE) remains associated with substantial mortality despite standard anticoagulation therapy.
- Trial name
- PRAGUE-26 (NCT05493163)
- Testing
- Thrombolytic, Standard anticoagulation
- Where
- Czechia
- Volunteers
- 558 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Pregnancy, Venous Thrombosis
Free DNA and Nucleosome Concentrations in Pathological Pregnancies
The primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: 1.
- Conditions
- Pregnancy, Venous Thrombosis, Pulmonary Embolism, Hypertension, Pregnancy-Induced
- Trial name
- NCT01736826
- Testing
- Bloodwork, baseline, Blood work, Months 1 & 2, Bloodwork, Months -1 to -6
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lung Cancer
Coagulation Profile in Patients Undergoing Video Assisted Thorascopic Surgery (VATS) for Lung Cancer
The purpose of the study is: To estimate patients with lung cancers who will undergo surgery total haemostatic / thrombotic capacity pre, per-and postoperatively.
- Trial name
- COPPVATS (NCT01741506)
- Testing
- Dalteparin (Fragmin®)
- Where
- 3 sites in Denmark
- Volunteers
- 116 people
- Sponsor
- Thomas Decker Christensen
Pulmonary Thromboembolisms, Pulmonary Embolism
Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events
Deep vein thrombosis (DVT) occurs when a blood clot forms in a deep vein, typically in the lower extremities. Pulmonary embolism (PE) occurs when a DVT clot (or fragment) breaks free and travels through the heart to the pulmonary…
- Trial name
- NCT03183063
- Testing
- 4DCT and SPECT/CT, 4DCT with BiPAP and SPECT/CT, 4DCT with CTA in suspected PE
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Thomas Guerrero
Venous Thrombosis
Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Deep Vein Thrombosis - The EINSTEIN DVT Study
This is a multicenter, randomized, open-label, assessor-blind, event-driven, non-inferiority program for efficacy with a study treatment duration of 3, 6 or 12 months in patients with confirmed acute symptomatic DVT without…
- Trial name
- NCT00440193
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Enoxaparin followed by VKA
- Where
- 324 sites in United States, Australia and 32 more
- Volunteers
- 3,449 people
- Sponsor
- Bayer
Deep Vein Thrombosis
Understanding Risk Factors Involved in Developing a Second Blood Clot.
The purpose of this study is to develop a way to predict which patients diagnosed with idiopathic blood clots can safely stop warfarin therapy after six months.
- Trial name
- NCT00261014
- Where
- 7 sites in Canada, France
- Volunteers
- 800 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
VTEval Project - Prospective Cohort Studies to Evaluate and Improve Diagnostics, Management Strategies and Risk Stratification in VTE
Venous thromboembolism (VTE) with its two clinical manifestations deep vein thrombosis (DVT) and pulmonary embolism (PE) is a life-threatening disease that is associated with considerable morbidity and mortality.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE)
- Trial name
- VTEval (NCT02156401)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Deep Vein Thrombosis, Thromboses, Venous
Ongoing Registry of Treatment of Venous Thromboembolism
Ongoing registration of patients with venous thromboembolism treated by means of antithrombotic therapy, thrombolisys, open surgery, endovenous desobstruction and stenting.
- Conditions
- Deep Vein Thrombosis, Thromboses, Venous, Thrombosis Embolism, Postthrombotic Syndrome
- Trial name
- RRT VTE (NCT03881345)
- Testing
- Anticoagulants, Open surgery, Thrombolysis
- Where
- Russia
- Volunteers
- 5,000 people
- Sponsor
- Medalp Private Surgery Clinic
Chronic Obstructive Pulmonary Disease, Patients Hospitalized for a COPD Exacerbation
Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT…
- Trial name
- PEP (NCT02035293)
- Testing
- PEP
- Where
- 7 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Acute Pulmonary Embolism
Evaluating the Safety and Efficacy of the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE for Treatment of Acute Pulmonary Embolism
To evaluate the safety and effectiveness of percutaneous mechanical aspiration thrombectomy using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE in a prospective trial of patients with acute intermediate-risk…
- Trial name
- APEX-AV (NCT05318092)
- Testing
- AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE
- Where
- 25 sites in United States
- Volunteers
- 122 people
- Sponsor
- Angiodynamics, Inc.
Venous Thromboembolism (VTE), Pulmonary Embolism
Hokusai Study in Pediatric Patients With Confirmed Venous Thromboembolism (VTE)
This is an event driven Phase 3, prospective, randomized, open-label, blinded endpoint evaluation (PROBE) parallel group study in subjects with confirmed VTE.
- Conditions
- Venous Thromboembolism (VTE), Pulmonary Embolism, Deep Vein Thrombosis (DVT)
- Trial name
- NCT02798471
- Testing
- Edoxaban, Standard of Care
- Where
- 140 sites in United States, Argentina and 32 more
- Volunteers
- 290 people
- Sponsor
- Daiichi Sankyo
Pulmonary Embolism
A Registry Study on Biomarkers of Pulmonary Embolism
The purpose of the study is to evaluate the value of biomarkers in the diagnosis and risk stratification of patients with suspected pulmonary embolism.
- Trial name
- BIO-PE (NCT04118634)
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Pulmonary Disease
The Role of Endothelial Function Test in Risk Stratification for Early and Late Complications After Pulmonary Embolism
The aim of this study is to investigate the association between endothelial dysfunction, measured by RHI as assessed by the peripheral arterial tonometry method, and PE complications defined as re-event of PE or DVT, systemic…
- Trial name
- NCT03149471
- Testing
- Endothelial dysfunction test
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Venous Thromboembolism, Covid19
COVID-19 and Venous Thromboembolism Risk
Coronavirus disease 2019 (Covid-19) is now a leading cause of death among U.S. adults. In addition to profound respiratory and multi-organ failure, hypercoagulable states and venous thromboembolism (VTE) have been increasingly…
- Trial name
- NCT04569344
- Testing
- Laboratory test positive for SARS-CoV-2 virus
- Where
- 2 sites in United States
- Volunteers
- 398,530 people
- Sponsor
- University of California, San Francisco
Pulmonary Embolism, Pulmonary Embolism Acute Massive
Registry of Catheter Intervention in Pulmonary Embolism
Multicenter longitudinal observational ambispective (retrospective cases from 2014 and prospective from 2018 onwards) cohort study.
- Conditions
- Pulmonary Embolism, Pulmonary Embolism Acute Massive, Pulmonary Embolism Acute, Pulmonary Embolism and Thrombosis
- Trial name
- RiTEP (NCT06348459)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital San Carlos, Madrid
Pulmonary Embolism
Diuretic Vascular Filling in the Initial Management of Acute PE With Right Ventricular Dysfunction Normotensive
Pulmonary embolism (PE) is a serious disease with frequent intra hospital mortality remains high. If anticoagulation is perfectly codified, the remainder of the initial management has been less studied.
- Trial name
- NCT02531581
- Testing
- Furosemide, NaCl 9% isotonic
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice