Clinical trials: Embolism
Hemodialysis Complication, Bleeding
Regional Anticoagulation of Dialysis Circuits With a Calcium-free Citrate-containing Dialysate
Critically ill patients have a high risk of bleeding but also require prolonged intermittent dialysis. Thus, a heparin-free easy-to-use alternative type of anticoagulation within the dialysis circuit is required.
- Trial name
- C2D (NCT03842657)
- Testing
- anticoagulation of the dialysis circuit
- Where
- 5 sites in France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Toulouse
Venous Thromboembolism, Risk Assessment
Multiple Algorithms System Of All Scores in Embolism (MOSE)
The aim of this study is to overcome the current limits of the scoring systems used to predict both the thrombotic (VTE) and hemorrhagic (BLD) risk for the patient.
- Conditions
- Venous Thromboembolism, Risk Assessment, Risk Management
- Trial name
- MOSE (NCT02911012)
- Where
- 2 sites in Italy
- Volunteers
- 15,208 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Raynaud Disease
Randomised Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma
In this double-blinded, placebo-controlled, fixed-dose, study patients will be randomly assigned to take placebo or 20 mg tadalafil thrice weekly for 6 weeks.
- Trial name
- NCT00626665
- Testing
- Tadalafil
- Volunteers
- 25 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Acute Deep Vein Thrombosis
Fragmin In The Treatment Of Acute Deep-Vein Thrombosis With Or Without Pulmonary Embolism In Cancer Patients
To collect postmarketing data about Fragmin safety and efficacy in the treatment of deep vein thrombosis with or without pulmonary embolism in cancer patients.
- Trial name
- NCT00480636
- Testing
- Fragmin (dalteparin sodium )
- Volunteers
- 102 people
- Sponsor
- Pfizer
COVID19, Thromboembolism
Impact of an Intensified Thromboprofylaxis Protocol in COVID-19
The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified…
- Trial name
- NCT04394000
- Testing
- thromboprofylaxis protocol, standard protocol
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Jessa Hospital
Inflammation, Thrombosis
Investigation on the Effect of Smoking on the Expression of Pro- and Anti-thrombotic, Anti-oxidative, and Inflammatory Markers in Humans
Investigation on the effect of smoking on thrombus formation in humans. The expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50 year old healthy smokers and non-smokers.
- Conditions
- Inflammation, Thrombosis, Smoking
- Trial name
- NCT02198937
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Atrial Fibrillation, Pulmonary Embolism
Screening for Atrial Fibrillation in Pulmonary Embolism Study -SAFE-PE Study
Patients with newly diagnosed pulmonary embolism and high thromboembolic risk will be randomized to screening for atrial fibrillation or standard of care using intermittent ECG registration for at least two weeks.
- Trial name
- SAFE-PE (NCT03274401)
- Testing
- Zenicor intermittent ECG device, 5 day ECG patch
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Danderyd Hospital
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Pulmonary Embolism
Prevalence of Pulmonary Embolism in Patients With Dyspnea on Exertion (PEDIS)
PEDIS Study is an observational, cross-sectional, multicenter Italian study conducted in a consecutive series of patients who refer to the Emergency Departments (either spontaneously or sent by their attending physicians) for the…
- Trial name
- PEDIS (NCT04454554)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Arianna Anticoagulazione Foundation
Arterial Occlusive Diseases, Peripheral Vascular Diseases
Alfimeprase for Thrombolysis in Acute Peripheral Arterial Occlusion
This trial is for patients with acute occlusion of one of the arteries supplying blood to the leg. The trial is designed to determine the safety and activity of a novel clot dissolving (thrombolytic) drug (alfimeprase).
- Conditions
- Arterial Occlusive Diseases, Peripheral Vascular Diseases, Thrombosis
- Trial name
- NCT00073554
- Testing
- Alfimeprase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- ARCA Biopharma, Inc.
Myocardial Infarction
Prevalence and Long-term Impact of Non-atherosclerotic CAD
Despite a relatively high prevalence of non-atherosclerotic coronary artery disease (NACAD) among young women, the majority of these abnormalities were misdiagnosed in this population, and thus treatments were not targeted…
- Trial name
- PRYME (NCT01479140)
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Cardiology Research UBC
Venous Thromboembolism (VTE)
Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)
The purpose of this study is to evaluate whether extended prophylaxis with oral betrixaban can prevent blood clots in the leg and lung that sometime occur in patients hospitalized for an acute medical illness and to compare these…
- Trial name
- APEX (NCT01583218)
- Testing
- Betrixaban, Enoxaparin
- Where
- 462 sites in United States, Argentina and 32 more
- Volunteers
- 7,513 people
- Sponsor
- Portola Pharmaceuticals
Venous Thrombosis, Neoplasms
Optimal Duration of Anticoagulation Therapy for Low-risk Pulmonary Embolism Patients With Cancer
The primary purpose of this study is to determine the optimal duration of anticoagulation therapy (6 months versus 18 months) with direct oral anticoagulant (DOAC) for cancer-associated low-risk pulmonary embolism patients.
- Conditions
- Venous Thrombosis, Neoplasms, Anticoagulants
- Trial name
- ONCO PE (NCT04724460)
- Testing
- Long DOAC, Short DOAC
- Where
- Japan
- Volunteers
- 179 people
- Sponsor
- Takeshi Morimoto
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Aorta Aneurysm
Graft Thrombosis After Endovascular Aortic Repair - a Single Center Experience With the Cook Zenith Alpha Spiral-Z®
The purpose of this study is to assess the extent of thrombosis in the Zenith Alpha Spiral-Z® stent graft.
- Trial name
- NCT04564560
- Testing
- Endovascular aortic repair with Zenith Alpha Spiral-Z®
- Where
- Norway
- Volunteers
- 161 people
- Sponsor
- St. Olavs Hospital
Pregnancy, Heart; Complications, Valve, Prosthesis
Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Pregnancy is associated with increased risk of thrombosis among women with mechanical prosthetic heart valves.However, the best anticoagulant treatment strategies for pregnant patients with prosthetic heart valves have been…
- Trial name
- NCT02240927
- Testing
- Low Molecular Weight Heparine : Enoxaparine, Enoxaparine and 2.5 mg Warfarin, Enoxaparine and 4mg Warfarin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Atrial Fibrillation, Deep Venous Thrombosis
Modeling Genotype and Other Factors to Enhance the Safety of Coumadin Prescribing
The study goal is to conduct a randomized controlled trial to compare safety and accuracy of dosing based on clinical information including the clinical reason for your taking coumadin, your age, gender, your body surface area…
- Conditions
- Atrial Fibrillation, Deep Venous Thrombosis, Heart Valve Replacement, Pulmonary Embolism
- Trial name
- NCT00484640
- Testing
- Coumadin
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Bleeding, Colorectal Disorders
Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery
The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding during and after major colorectal surgery.
- Conditions
- Bleeding, Colorectal Disorders, Thromboembolism, Tranexamic Acid
- Trial name
- NCT06657924
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Kristen Ban
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca