Clinical trials: Embryo
Infertility
Predictive Value of Embryonic Testing
The primary objective of this study is to determine the predictive value of preimplantation genetic screening (PGS) as a marker of embryonic competence.
- Trial name
- PROV-ET (NCT03604107)
- Testing
- Preimplantation Genetic Testing-Aneuploidy
- Where
- 4 sites in United States
- Volunteers
- 237 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Pain Management, Infertility (IVF Patients)
The Effect of Music Medicine on Anxiety and Pain Levels in Women Undergoing Embryo Transfer: A Randomized Controlled Trial
This study was designed to investigate the effects of music medicine on anxiety, pain, and vital signs in women undergoing embryo transfer.
- Conditions
- Pain Management, Infertility (IVF Patients), Anxiety
- Trial name
- NCT07370857
- Testing
- "Patient-Selected Music Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Hasan Kalyoncu University
Duration of Estrogen Administration
The Impact of Estrogen Administration Duration in Hormonally Prepared Frozen Embryo Transfer Cycles
This prospective controlled study aimed to investigate the effect of the duration of estrogen (E2) administration prior to progesterone (P) initiation on live birth rates (LBR) in frozen embryo transfer (FET) cycles.
- Trial name
- NCT05825885
- Testing
- E2
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Akdeniz University
Melanoma
Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma
This is an interventional mono-centric study in patients with BRAF mutated metastatic melanoma treated with BRAF/MEK inhibitors.
- Trial name
- MELANOPREDICT (NCT04039672)
- Testing
- Skin biopsy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Age Related Macular Degeneration
A Study of Implantation of Retinal Pigment Epithelium in Subjects with Acute Wet Age Related Macular Degeneration
Phase 1 trial of retinal pigment epithelium replacement in subjects with wet age-related macular degeneration in whom there is rapidly progressing vision loss
- Trial name
- NCT01691261
- Testing
- PF-05206388
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Pregnancy
PGT-A Versus Blastocyst Morphology Selection
Introduction Embryo aneuploidy is likely the leading cause of implantation failure in IVF cycles. Since the inception of IVF, non-invasive morphology based scoring has been the most widely used embryo selection method, resulting…
- Trial name
- NCT03095053
- Testing
- comprehensive chromosome screening
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people
- Sponsor
- Antalya IVF
IVF
What is the Impact of Frozen Embryo Transfer Protocol, on Endometrial Compaction
This study aims to evaluate endometrial thickness on the day of the frozen embryo transfer, compared to endometrial thickness on the last day of assessment of the endometrium before exposure to progesterone in respect to the…
- Trial name
- NCT06251596
- Where
- Israel
- Volunteers
- 247 people
- Sponsor
- Hillel Yaffe Medical Center
Fertility Disorders
Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready.
- Trial name
- NCT06053827
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo
Infertility
Gametes Transfer vs. Embryo Transfer for Women Undergoing Assisted Reproductive Techniques: a Randomized Controlled Trial
Background: The cost for the treatment of infertility are limiting for the health care access, particularly if we consider that the success rate per cycle is approximately 35%.
- Trial name
- NCT01839136
- Testing
- Intrauterine transfer of gametes, Intrauterine transfer of embryos
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Infertility, Female
Personal FET in RIF Patients According to Histological Dating of Endometrial of Natural/ Hormone Replacement Cycle
At present, the evaluation criterion of endometrial receptivity is controversial. The development of a molecular diagnostic tool, the endometrial receptivity array (ERA) for diagnosis of endometrial receptivity .
- Trial name
- NCT03312309
- Testing
- personal embryo transfer
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Temperature; Extreme, Exposure
Embryo Culture At a Constant Temperature of 36.6°C or 37.1°C
On the day of oocyte retrieval, participants will be randomized to stable culture at 37.1°C or 36.6°C with the ultimate aim of finding a difference in clincial pregnancies.
- Trial name
- NCT03548532
- Testing
- G210 incubator
- Where
- Belgium
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Endometrial Disorder
Comparing Two Types of Endometrial Activation Prior to Embryo Transfer
To determine if two types of endometrial activation (Pipelle curette or Shepard catheter) prior to embryo transfer result in similar live birth rates.
- Trial name
- NCT04363879
- Testing
- Endometrial scratch with Pipelle curette, Endometrial scratch with Shepard catheter
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Polycystic Ovary Syndrome, Assisted Reproduction
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
Ninety women with PCOS candidate for ICSI were randomized to 2 groups:Group A: fresh samples of PCOS patients undergoing IVF (no= 45) and Group B: frozen samples of PCOS patients undergoing IVF (no= 45).
- Trial name
- NCT03820167
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Endometrium, Laser
Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium
We will recruit 30 poor ovarian responders and thin endometrium patients, aged 35-45 year old, and treat with intravascular laser irradiation of blood (ILIB) via an intravenous catheter for irradiation of the blood under a period…
- Trial name
- NCT03081130
- Testing
- Intravenous laser irradiation treatment
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility, Preimplantation Genetic Diagnosis/Screening
Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer
The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in association with the efficacy and security of vitrification and trophectoderm biopsy, more efficient stimulation schemes and laboratory…
- Conditions
- Infertility, Preimplantation Genetic Diagnosis/Screening, Miscarriage
- Trial name
- NCT03395665
- Testing
- Estradiol level, Progesterone level, Endometrial thickness
- Where
- Spain
- Volunteers
- 299 people
- Sponsor
- Fundacion Dexeus
to Evaluate the Feasibility and Accuracy of Using cfDNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for PGD
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
This study aims to evaluate the feasibility and accuracy of using cfDNA analysis of spent embryo culture media as a non-invasive approach for PGD. Specifically, the objectives of the study are: 1.
- Trial name
- NCT07076719
- Testing
- Trophectoderm (TE) Biopsy, Non-invasive Preimplantation Genetic Diagnosis
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Sohag University
Embryo Culture, Embryo Culture Media
Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles
This is a prospective, multicenter, randomized controlled clinical trial designed to evaluate whether a fully undisturbed closed embryo culture system can improve the developmental potential of embryos cultured in vitro and…
- Conditions
- Embryo Culture, Embryo Culture Media, Embryo Quality
- Trial name
- Embryos UECS (NCT07522281)
- Testing
- Gems FEM fertilization medium + Geri incubator+Gems one-step medium, Vitrolife fertilization medium+benchtop incubator + Vitrolife sequential culture media
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hepatic Sarcoma
Undifferentiated Embryonal Sarcoma of the Liver: Evaluation of the Relapse Profile According to the Therapies Administered
Undifferentiated embryonal sarcoma of the liver is the 3rd most common malignant liver tumor after hepatoblastoma and hepatocellular carcinoma with a peak incidence between 6 and 10 years of age.
- Trial name
- SARCOM (NCT05640960)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Human Embryo Cryopreservation
Comparison Between Three Freezing Protocols to Preserve Human Embryos
This randomized study compares three different freezing methods to store human in vitro fertilization (IVF) embryos: vitrification with two commercial kits or slow freezing.
- Trial name
- NCT00910390
- Testing
- Slow freezing, VIT-Irvine, Vit-Vitrolife
- Where
- Belgium
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Embryo Culture Media, Metabolomics
Targeted Metabolomics and Spent Embryo Culture Medium
More than 8 million babies have been born through in vitro fertilization (IVF). Non-invasive observation of embryos in vitro to better understand their development is becoming increasingly important.
- Trial name
- NCT06094439
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- gyn-medicum Göttingen