Clinical trials: Embryo Culture Media
Infertility
Study of Free DNA Content of Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment
Study of Cell Free DNA Content of Human Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment in intra cytoplasmic sperm injection Treatment Cycles.
- Trial name
- NCT02480491
- Testing
- measuring cell freeDNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sadat City University
Clinical Pregnancy Rate
Does the Volume of the Embryo Culture Medium During Embryo Transfer Affects the IVF Outcomes?
The aim of this study was to evaluate if higher volume (40-45μl VS 20-25 μl) of media used for embryo transfer affects the clinical outcomes in fresh IVF cycles.Patients who fulfilled the inclusion criteria and agreed to…
- Trial name
- NCT03350646
- Testing
- Volume of medium during embryo transfer
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Embryo Culture Media, Metabolomics
Targeted Metabolomics and Spent Embryo Culture Medium
More than 8 million babies have been born through in vitro fertilization (IVF). Non-invasive observation of embryos in vitro to better understand their development is becoming increasingly important.
- Trial name
- NCT06094439
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- gyn-medicum Göttingen
Poor Ovarian Response, Female Infertility of Other Origin
Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF
Evaluating the Efficacy of Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF Summary: This is a prospective, randomized controlled trial designed to…
- Conditions
- Poor Ovarian Response, Female Infertility of Other Origin, Oocyte Immaturity
- Trial name
- EXOMAT (NCT07085312)
- Testing
- Exosome-Enriched IVF Culture
- Where
- Venezuela
- Volunteers
- 10 people
- Sponsor
- Fertiaguerrevere
Infertility, Reproductive Techniques, Assisted
An Alternative Culture Medium to Better Support Preimplantation Embryo Development in Vitro
The purpose of this research study is to evaluate a newly developed embryo culture media system for human clinical use in ART.
- Trial name
- NCT02457481
- Testing
- Embryo Culture medium
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Foundation for Fertility Research
Infertility
Comparison of Culture Media for in Vitro Embryo Development
The purpose of this study is to collect development and outcome data on human embryos which are cultured in a 2nd generation continuous single culture medium (CSCM2) with the objective to demonstrate its performance efficacy in…
- Trial name
- NXGeM (NCT02846012)
- Testing
- CSCM2
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ovation Fertility
Infertility/Sterility
Markers in Follicular Fluid and in Embryo Culture Medium as a Marker of Oocyte and Embryo Quality
Assessment of the quality of follicular fluid and early embryo via chemical markers.
- Trial name
- NCT03350009
- Where
- Israel
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Blastocyst Disintegration
A Comparison Between Home-made Vitrification & Thawing Media and a Commercially Available Brand on Blastocyst
This study was conducted to evaluate and compare cryo-survival, re-expansion, and implantation rates of Day 5/6 human blastocysts that were vitrified with home-made media (HM) according to (Shady grove protocol) and warmed with…
- Trial name
- NCT03660904
- Testing
- home made vitrification & thawing kit, commercially made vitrification & thawing kit
- Volunteers
- 74 people
- Sponsor
- Benha University
Infertility
Validation of Addition of Uterine Fluid to Human Embryo Culture Medium
Infertility or infertility affects about 15% of couples of reproductive age. It is estimated that 80 million people around the world suffer from this problem.
- Trial name
- NCT03436758
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- IVI Murcia
Embryo Quality
Outcomes of the Embryos of Different Ovarian Follicle Sizes, and the miRNA Detection in Their Blastocyst Culture
In this study, it is aimed to analyze the outcomes of embryos obtained from ovarian follicle with different sizes, and identify the microRNA expression in the spent media of the blastocysts cultures.
- Trial name
- NCT05947526
- Testing
- Oocyte pick-up
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Embryo Development
Impact of Culture Medium on Embryo Quality
The purpose of this study is to compare two culture media.
- Trial name
- NCT01094314
- Testing
- embryo culture medium
- Where
- Belgium
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Improvement of Embryo Transfer Technique, Improvement of Implantation
Comparative Study of Three Different Embryo Transfer Media in ICSI Cycles
The study design is a prospective randomized uncontrolled clinical trial. It will include 150 cases. The aim of this study is to compare the efficacy of three different media used for embryo transfer regarding "chemical and…
- Trial name
- NCT02792673
- Testing
- embryos will be transferred using a medium of 0.5 mg/mL of Hyaluronan-enriched medium (EmbryoGlue®, Vitrolife, Sweden), embryos will be transferred using a medium of 30% Protein-supplemented Culture Medium (Global total®, Life Global group, Canada), a novel technique in which embryos will be transferred using a medium of autologous Follicular Fluid
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- South Valley University
Infertility, Chromosome Abnormality
Embryo Selection by Noninvasive Preimplantation Genetic Test
The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by…
- Trial name
- ESNi-PGT (NCT04339166)
- Testing
- Non-invasive chromosome screening（NICS）
- Where
- 13 sites in China
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Poor Responder, Severe Male Infertility
Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
In this study the suitability of two -sequential and single step- commercially available culture media from the same brand was compared.
- Conditions
- Poor Responder, Severe Male Infertility, Embryo Development, Blastocyst
- Trial name
- NCT02575924
- Testing
- sequential medium, 1-step medium
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- European Hospital
Control Media Only, Study hCG and Media
Intrauterine Human Chorionic Gonadotropin at the Time of Embryo Transfer
Techniques to improve pregnancy and delivery rates in IVF cycles have focused not only on the embryos transferred, but also the conditions in the uterus at the time of transfer and implantation.
- Trial name
- NCT01643993
- Testing
- hCG at the Time of Embryo Transfer, Control
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Embryo Growth Disorder, Humans
Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)
The objective of this study is to compare, through a multicentric randomized trial, the impact of two pH values in the embryo culture medium on the clinical results of In Vitro Fertilization (IVF) process and especially the…
- Conditions
- Embryo Growth Disorder, Humans, Pregnancy
- Trial name
- ACIDOFIV (NCT04456478)
- Testing
- pH at 7.38 ± 0.02, pH at 7.22 ± 0.02
- Where
- 3 sites in France
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Aneuploidy, Chromosome Abnormality
RCT Study to Validate niPGT-A Clinical Benefit.
Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidies are reported to prevent implantation.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A_RCT (NCT04000152)
- Testing
- niPGT-A, Morphology criteria
- Where
- 8 sites in Argentina, Brazil and 3 more
- Volunteers
- 296 people
- Sponsor
- Igenomix
Females Undergoing PGD Technology for Medical Conditions
Isolation of Cell Free Fetal DNA From Spent Culture Medium and Its Potential Role for Preimplantation Genetic Diagnosis (PGD).
Preimplantation genetic testing for chromosomal screening is, at present, the most reliable method to assess the genetic status of preimplantation embryos.
- Trial name
- NCT06084377
- Testing
- Preimplantation Genetic Screening
- Where
- Syria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Damascus University
Pregnancy, Fertility
Prognostic Value of PIF Detection in Embryo Culture Media Correlation With Pregnancy Outcome
PIF: biomarker of successful implantation To overcome the poor reproductive potential of embryos generated during in vitro fertilization cycles and the lack of markers enabling the identification of the most competent ones, it is…
- Trial name
- PIF-SET1 (NCT01803893)
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 500 people
- Sponsor
- BioIncept LLC
Infertility
Efficacy of Endocell® vs Conventional Medium in the Treatment of Infertility
The aim of this study is to demonstrate the efficacy of a single embryo transfer at blastocyst stage (Day 5) after co-culture on Autologous Endometrial Cell Culture (AECC) versus transfer of a single embryo at Day 3 after culture…
- Trial name
- NCT01058603
- Testing
- - Conventional culture medium for IVF, - Endocell®
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Laboratoires Genévrier