Clinical trials: Embryo Development
Infertility
Artificial Intelligence in Embryo Selection in Assisted Reproduction for Embryos Cultured to the Fifth Day of Development
Embryo selection is one of the major challenges in Assisted Reproductive Technology (ART) in order to continuously improve clinical pregnancy rates.
- Trial name
- IASEAMP (NCT07844083)
- Testing
- EMA
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Clermont-Ferrand
In Vitro Human Embryo Development
Improving Embryogenesis by Adding Growth Factors to In Vitro Human Culture Media
The investigators suppose that adding growth factors that had been found in the female tubal fluid and uterus to In Vitro single step culture media for human embryos might improve the the embryogenesis In Vitro and the clinical…
- Trial name
- GFSSSCM (NCT02426008)
- Testing
- Growth Factors and Cytokine adding to embryo culture media, No Intervention
- Where
- Egypt
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Embryo Development
Outcome of Embryo Culture at Two Oxygen Tensions
The purpose of this study is to assess whether reduced oxygen tension in embryo culture has any effect on clinical outcome.
- Trial name
- NCT00718822
- Testing
- oxygen concentration in the culture atmosphere
- Where
- Slovenia
- Volunteers
- 647 people
- Sponsor
- University Medical Centre Maribor
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Thalassemia,Embryonic Development,Reproductive Sterility and Infertility
A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development
Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China.
- Trial name
- NCT03687567
- Testing
- Preimplantation genetic diagnosis
- Where
- China
- Volunteers
- 737 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Spermatic Parameters, Embryonic Kinetics
Impact of Nuclear Human Sperm Quality on Embryo Development
To date, none study shows the impact of human spermatozoa nuclear alteration on embryonic development kinetic with morpho-kinetics tools.
- Trial name
- PRIMOSPERMO (NCT03320590)
- Testing
- Time Lapse (material to observe embryonic development)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility
A Study Using Recombinant Human Chorionic Gonadotrophin (rhCG, Ovidrel®) in the Induction of Final Follicle Maturation and Early Luteinization in Chinese Women Undergoing in Vitro Fertilization and Embryo Transfer (IVF/ET)
This was an open, randomized, comparative study using rhCG (Ovidrel) in the induction of final follicle maturation and early luteinization in Chinese female subjects undergoing IVF or ET.
- Trial name
- NCT01081756
- Testing
- r-hCG, Urinary-hCG
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Results Following the Vitrification of Human Oocytes Using 2 Methodologies
The investigators are going to compare embryo developmental rates of human eggs following freezing in two different freezing methods.
- Trial name
- NCT01033474
- Where
- Peru
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Reproductive Sciences
Embryo Development
Impact of Culture Conditions on the Embryo Quality
The purpose of this study is to compare different culture conditions. The effect of the type of incubator (standard versus mini-incubator) and the effect of the oxygen concentration (5% versus 20%) will be evaluated on the embryo…
- Trial name
- NCT01767805
- Testing
- Standard incubator, Mini incubator, 5% oxygen
- Where
- 2 sites in Belgium
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
IVF Outcomes
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well.
- Trial name
- HELIOS-A (NCT07425080)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Columbia University
Implantation, Embryo
Longitudinal Clinical Observation of a Digital Twin Model for Blastocyst Evaluation in IVF Clinics
This study aims to develop and validate a non-image, multimodal digital twin model of the human blastocyst using fully de-identified clinical, laboratory, molecular, biochemical, and long-term follow-up data obtained during…
- Trial name
- IVFDT (NCT07305480)
- Testing
- Digital Twin Computational Modeling
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Ukraine Association of Biobank