Clinical trials: Embryonic Development
Infertility
Single-step Versus Sequential Media in Preimplantation Embryo Development and Pregnancy Rates
Sequential culture media were introduced in order to meet the changing requirements of the developing embryo in vitro. However, there has been renewed interest in the use of single-step media, which allow the embryo itself to…
- Trial name
- NCT02048527
- Testing
- Global, Origio
- Where
- Greece
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Eugonia
Infertility, Male, Sperm Count, Low
Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.
It has been described that 11% of men with semen values within the normal range established by the World Health Organization (WHO) have sperm DNA fragmentation.
- Trial name
- ZYMOT2 (NCT06384794)
- Testing
- Sperm capacitation through the ZyMōt®Sperm Separation Device®, Swim-up
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Artificial Intelligence in Embryo Selection in Assisted Reproduction for Embryos Cultured to the Fifth Day of Development
Embryo selection is one of the major challenges in Assisted Reproductive Technology (ART) in order to continuously improve clinical pregnancy rates.
- Trial name
- IASEAMP (NCT07844083)
- Testing
- EMA
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility, Female, IVF
MVA to Improve the Pregnancy Outcome in Aged Infertility Women With Assisted Reproductive Technology
The goal of this clinical trial is to test MVA on improving pregnancy outcome in elderly infertile patients undergoing invitro fertilization (IVF).
- Conditions
- Infertility, Female, IVF, Reproductive Disorder, Oocyte
- Trial name
- NCT05788822
- Testing
- Mevalproic acid
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Nanjing University
Infertility,Female
Growth Hormone Adding to Controlled Ovarian Hyperstimulation for Improving Embryo Quality
GH plays an important role in the synthesis of ovarian steroid hormone and follicular development as a paracrine hormone.GH can regulate the growth hormone receptor and strengthen the function of mitochondria to improve the…
- Trial name
- NCT03966339
- Testing
- Growth hormone
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Embryonic Development, Infertility
Culture Media Microdroplet Geometry With Different Oil Overlay and Its Effect on Embryonic Development.
A prospective randomized study included 1695 MII sibling oocytes collected from 100 patients undergoing ICSI.
- Trial name
- NCT04485806
- Testing
- GPS/LM, SPL/LM, GPS/PO
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ganin Fertility Center
Infertility, Pregnancy, Multiple
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization
The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.
- Trial name
- EMECH (NCT02530892)
- Testing
- EmbryoHug
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stanford University
IVF, Oocyte Maturation Defect 1
IVF Outcome Following Progestogen Ovarian Stimulation
The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS).
- Conditions
- IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation
- Trial name
- NCT04175990
- Testing
- Dydrogesterone Pill
- Where
- Malaysia
- Volunteers
- 155 people
- Sponsor
- National University of Malaysia
IVF Outcomes
HELIOS: Human Embryo Illumination to Enhance Development
Embryos need a lot of energy to grow, but as women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for embryos to develop normally.
- Trial name
- HELIOS (NCT07311928)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Infertility
Adding Cytokines to In Vitro Human Culture Media to Improve Embryogenesis and Implantation
Assessment of the embryological benefit of in vitro adding of Cytokines (LIF 5ng/ml, HB-EGF 5ng/ml and GM-CSF 2n/ml) to the culture media and closely monitor its effect on embryogenesis and implantation outcomes.
- Trial name
- GHLCSHED (NCT02420886)
- Testing
- Adding LIF, HB-EGF and GM-CSF to Lifeglobal human IVF culture media
- Where
- 2 sites in Egypt
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist
The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting.
- Trial name
- NCT00835523
- Where
- 10 sites in Germany
- Volunteers
- 51 people
- Sponsor
- University Hospital Schleswig-Holstein
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Embryonic Development, Embryo Morphokinetics
Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
The purpose of this study is to investigate the development of human embryos in vitro under two different oxygen concentrations; a static 5% during all five days of culture or under an oxygen gradient, starting with 8% from day-0…
- Conditions
- Embryonic Development, Embryo Morphokinetics, Embryo Morphometry
- Trial name
- NCT05898178
- Testing
- Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
- Where
- Slovenia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor